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Wastewater-Based Epidemiology (WBE) Research, 2nd Edition

A special issue of Water (ISSN 2073-4441). This special issue belongs to the section "Water and One Health".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 269

Special Issue Editors

College of Water Sciences, Beijing Normal University, Beijing, China
Interests: wastewater-based epidemiology; illicit drugs; emerging contaminants; health risk assessments; biomarkers
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Queensland Alliance for Environmental Health Sciences, University of Queensland, Brisbane, Australia
Interests: new biomarkers for WBE; new application of WBE; method uncertainties; COVID-19; pathogens
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wastewater-based epidemiology (WBE), through analysing relevant biomarkers in wastewater, can provide near-real-time information on the level of consumption or exposure to a range of chemicals and pathogens experienced by the population living within target catchment boundaries. This approach has been developed and applied for more than a decade and started with the monitoring of illicit drug use around the world. WBE has been adopted by authorities and policy makers to find evidence and formulate drug control strategies.

In recent years, particularly since 2020, the use of WBE has expanded into both risk assessments of the consumption, use, exposure, or release of chemicals and early warnings about infectious disease spread and antibiotic resistance at the community level. There have been thousands of WBE studies on COVID-19 monitoring published in the last two years. Despite this success, many challenges still prevent WBE from reaching its full potential as a complementary monitoring tool for epidemiological studies of human health. This Special Issue welcomes both original research papers and systematic reviews on various aspects of WBE, from the application of this approach in new areas with special demographics to exploratory studies advancing the science of this field. We encourage the submission of interdisciplinary work and collaborative research that identify new biomarkers for WBE and triangulate WBE data with other data sources. We also encourage the submission of manuscripts that focus on COVID-19 and other pathogens.

Dr. Peng Du
Dr. Phong Thai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Water is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new biomarkers for WBE
  • new applications of WBE
  • early warning of infectious disease
  • monitoring substances of abuse
  • method uncertainties
  • health risk assessments

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Published Papers (1 paper)

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Research

16 pages, 1682 KiB  
Article
Wastewater Surveillance for Benzodiazepines in Wuhu, China: Occurrence, Removal, and Consumption Patterns
by Menglin Zhao, Zhu Zhu, Ruyue Zhang, Ke Ma, Lingrong Zhang, Dandan Li and Peng Du
Water 2025, 17(8), 1204; https://doi.org/10.3390/w17081204 - 17 Apr 2025
Viewed by 217
Abstract
Benzodiazepines (BZDs), potent sedative and hypnotic drugs widely prescribed in psychiatry, pose a high risk of dependence and are globally abused. This study used wastewater-based epidemiology to investigate the consumption patterns of BZDs across four wastewater treatment plants (WWTPs) in Wuhu, China. A [...] Read more.
Benzodiazepines (BZDs), potent sedative and hypnotic drugs widely prescribed in psychiatry, pose a high risk of dependence and are globally abused. This study used wastewater-based epidemiology to investigate the consumption patterns of BZDs across four wastewater treatment plants (WWTPs) in Wuhu, China. A total of 16 BZDs and three metabolites were detected in influents and effluents, with concentrations reaching up to 90 ng/L (quetiapine fumarate) and 18.4 ng/L (diazepam). Most BZDs had a poor removal efficiency except quetiapine fumarate (>98% removal). The consumptions of BZDs in WWTPs ranged from <0.02 (lormetazepam) to 2700 mg/day/1000 people (quetiapine fumarate). Seasonal variation was found in BZD usage, where the consumptions in winter and spring were significantly higher than those in summer and autumn. It was worth noting that nimetazepam may be abused during the sampling campaign. Urban areas with higher housing prices match higher BZD consumption, correlating with greater stress and insomnia rates. This study reveals the relationship between socioeconomic factors and BZD consumption patterns, provide a new path to addressing community public health. Full article
(This article belongs to the Special Issue Wastewater-Based Epidemiology (WBE) Research, 2nd Edition)
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