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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innate and Adaptive Immune Responses to Arbovirus Infections

edited by Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes and

Rafael Freitas de Oliveira França

submission deadline 31 Oct 2025 | 2 articles | Viewed by 7048 | Submission Open

Keywords: arbovirus; innate immunity; adaptive immunity; immunotherapeutic; immunoprophylaxis; vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0

edited by

Sonia Moretti

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4546 | Submission Open

Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities

(This special issue belongs to the Section Human Virology and Viral Diseases)

Biotechnological Applications of Phage and Phage-Derived Proteins 2025

edited by

Silvio Santos

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4008 | Submission Open

Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic

(This special issue belongs to the Section Bacterial Viruses)

Viruses Associated with Gastroenteritis

edited by

Celso Cunha

and

Claudia Istrate

submission deadline 31 Oct 2025 | 5 articles | Viewed by 3887 | Submission Open

Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

HIV Neurological Disorders: 2nd Edition

edited by

Frank Denaro

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3450 | Submission Open

Keywords: neuroinflammation; chronic HIV inflammation; HIV reservoir; HIV proteins; HIV receptors; HIV models; drugs of abuse; AIDS dementia complex; HIV noninfectious comorbidities; HIV healthcare disparities; HIV neuropathology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Hemorrhagic Disease

edited by Joseph W. Golden and Aura R. Garrison

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3054 | Submission Open

Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses

(This special issue belongs to the Section Animal Viruses)

Bunyaviruses 2025

edited by Natasha L. Tilston-Lunel, Kenneth A. Stapleford and Ryan F. Relich

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1726 | Submission Open

Keywords: bunyaviruses; viral evolution; reassortment; vector biology; pathogenesis; animal models; vaccines and therapeutics

(This special issue belongs to the Section General Virology)

Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition

edited by

Alberto Borghetti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1490 | Submission Open

Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology of Re-Emerging Arboviruses: Genetics and Ecology Insights

edited by

Marta Giovanetti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1298 | Submission Open

Keywords: arboviruses; climate change; epidemic– pandemic preparedness; genomic surveillance

(This special issue belongs to the Section Animal Viruses)

Current ART, Virologic Failure and Implications for HIV Drug Resistance, 2nd Edition

edited by Susan M. Schader

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1097 | Submission Open

Keywords: antiretroviral therapy (ART); HIV; AIDS; drug resistance; low level viremia (LLV); very low level viremia (VLLV); virologic failure (VF); clinical failure; viral load (VL); viral suppression; long-acting injectables (LAI); pre-exposure prophylaxis (PrEP); first-line ART; second-line ART; target detected; target not detected (TND); viral blips; novel mechanisms of HIV drug resistance; acquired genotypic drug resistance; adherence; people living with HIV (PLWH); management of people living with HIV (PLWH); risk factors; genotype; phenotype; treatment efficacy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Regulation of HIV-1 Transcription and Latency, 2nd Edition

edited by

Uri Mbonye

submission deadline 31 Oct 2025 | 1 articles | Viewed by 684 | Submission Open

Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging and Re-emerging Infections: Impact on Substances of Human Origin (SoHO)

edited by

Ilaria Pati

and

Simonetta Pupella

submission deadline 31 Oct 2025 | Viewed by 495 | Submission Open

Keywords: substances of human origin (SoHO); infectious diseases; emerging and re-emerging infections; transmission risk

(This special issue belongs to the Section Human Virology and Viral Diseases)

Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals

edited by

Jing Zhang

submission deadline 31 Oct 2025 | 1 articles | Viewed by 406 | Submission Open

Keywords: vaccines; antiviral drugs; domestic animals; virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

One Health Approach: Tackling the Spillover of Zoonotic Viruses from Wildlife to Humans

edited by Gilberto Sabino-Santos,

Jamie Kristine Reaser

and

Kirk Douglas

submission deadline 31 Oct 2025 | Viewed by 374 | Submission Open

Keywords: One Health; spillover; viruses; emerging viruses

(This special issue belongs to the Section Animal Viruses)

Virus Infections and Host Metabolism 2025

edited by

Kuan Rong Chan

Yaw Shin Ooi

and Liang Cui

submission deadline 31 Oct 2025 | Viewed by 357 | Submission Open

Keywords: host– virus interactions; host response to viruses; immunometabolism; viral pathogenesis; metabolic reprogramming; metabolome; metabolism; lipidomics

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

The Immunosocial Approach to Emerging and Re-Emerging Viral Infections

edited by

Yiu Wing (Jason) Kam

submission deadline 31 Oct 2025 | Viewed by 305 | Submission Open

Keywords: viral infections; immunosocial approach; public health

(This special issue belongs to the Section General Virology)

Influenza Viruses in Wildlife 2025

edited by

Rebecca Poulson

and Wendy Blay Puryear

submission deadline 31 Oct 2025 | Viewed by 172 | Submission Open

Keywords: avian influenza; wild birds; wildlife; influenza epidemiology; surveillance; HPAI

(This special issue belongs to the Section Animal Viruses)

Vesicular Stomatitis Virus (VSV) 2025

edited by Michael A. Whitt,

Chad Mire

, Luis L. Rodriguez and

Andrea Marzi

submission deadline 31 Oct 2025 | Viewed by 159 | Submission Open

Keywords: pathogenesis; innate immune evasion; virus– vector interactions; virus– host interactions; epidemiology; entry; assembly; replication; transcription; vaccine; oncolytic

(This special issue belongs to the Section Animal Viruses)

Enteric Viruses in Environment and Humans: Identification, Surveillance and Control

edited by

Rita De Cássia Compagnoli Carmona

and Maria Inês Zanoli Sato

submission deadline 31 Oct 2025 | Viewed by 133 | Submission Open

Keywords: enteric viruses; wastewater-based epidemiology; human-based epidemiology; One Health

(This special issue belongs to the Section Human Virology and Viral Diseases)

2nd Edition: How to Adjust the Action Steps for Achieving the Global Hepatitis Virus (HBV/HCV/HDV) Elimination Targets?

edited by Ferruccio Bonino

submission deadline 31 Oct 2025 | Viewed by 119 | Submission Open

Keywords: antivirals; chronic viral hepatitis infections; HBV; HBV; functional cure; HCV; HCV vaccine; HDV; HDV-RNA; anti-HD

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Economically Important Viruses in African Crops

edited by James Peter Legg, Stephen Winter,

Rudolph Rufini Shirima

and

Samar Sheat

submission deadline 31 Oct 2025 | Viewed by 119 | Submission Open

Keywords: economically important viruses; african crops; cassava; banana; potato; yams; beans; cowpeas; maize; cacao; tomatoes; peppers; rice yellow mottle virus; chili; okra

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Multiscale Modeling and Forecasting of COVID-19 and Respiratory Virus Dynamics

edited by

Gerardo Chowell

and Sunmi Lee

submission deadline 31 Oct 2025 | Viewed by 98 | Submission Open

Keywords: COVID-19 modeling; respiratory virus dynamics modeling; epidemic forecasting; parameter identifiability; multiscale transmission dynamics

(This special issue belongs to the Section General Virology)

Neurocognitive Dynamics and Biomarkers in HIV

edited by Mattia Trunfio and Carmela Pinnetti

submission deadline 1 Nov 2025 | 2 articles | Viewed by 1294 | Submission Open

Keywords: HIV infection; neurodegeneration; biomarkers; neuroinflammation; cognitive performance; mood; central nervous system

(This special issue belongs to the Section Human Virology and Viral Diseases)

Opportunistic Viral Infections, 3rd Edition

edited by

Carlo Contini

submission deadline 7 Nov 2025 | Viewed by 80 | Submission Open

Keywords: epidemiology of opportunistic viral infections; immunocompromised individuals (HIV/AIDS; transplants; tumors; chemotherapeutics; biotechnological drugs; etc.); advances in diagnosis; management and treatment of opportunistic viral infections; JC virus; HPV; CMV; EBV and other herpesvirus; human T-cell leukemia virus type 1 (HTLV-1); hepatitis B virus (HBV) and hepatitis C virus (HCV); polyomavirus; new Coronavirus including SARS-CoV-2; emerging viruses (arbovirus other zoonotic virus)

(This special issue belongs to the Section General Virology)

Host-Directed Antiviral Therapy

edited by

Leike Zhang

and

Ke Xu

submission deadline 15 Nov 2025 | Viewed by 367 | Submission Open

Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral– host interplay

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Recent Advances on Arboviruses Pathogenesis and Evolution

edited by Mariana Sequetin Cunha

submission deadline 17 Nov 2025 | 2 articles | Viewed by 2206 | Submission Open

Keywords: virus outbreaks; phylogeny; virus evolution; pathology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging Concepts in SARS-CoV-2 Biology and Pathology, 3rd Edition

edited by

Daniele Focosi

submission deadline 28 Nov 2025 | Viewed by 330 | Submission Open

Keywords: SARS-CoV-2; epidemiology; virology; therapeutics; zoonoses

(This special issue belongs to the Section Coronaviruses)

Advances in Plant Virus/Viroid Detection and Identification Methods, 2nd Edition

edited by Laura Tomassoli and

Antonio Tiberini

submission deadline 28 Nov 2025 | Viewed by 66 | Submission Open

Keywords: plant viruses and viroids diagnostics; high-throughput sequencing; bioinformatics; virus taxonomy; virus/viroid– plant– vector interactions; real-time PCR; digital droplet PCR; hyperspectral imaging; machine learning; artificial intelligence; biosensors

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Molecular Mechanisms and Clinical Manifestations of Persistent Viral Infections

edited by

Anna Rosa Garbuglia

and Simone La Frazia

submission deadline 30 Nov 2025 | 7 articles | Viewed by 21089 | Submission Open

Keywords: mammalian viruses; chronic infection; latent infection; pathogenetic mechanisms; molecular pathways; oncogenic processes; episomal genome; host-integrated genome; immunity; antiviral drugs; endogenous viral element

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses

edited by

Sasan Fereidouni

submission deadline 30 Nov 2025 | 8 articles | Viewed by 15054 | Submission Open

Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission

(This special issue belongs to the Section Animal Viruses)

Advances in Rabies Research 2024

edited by

Charles E. Rupprecht

and Juan A. Montaño-Hirose

submission deadline 30 Nov 2025 | 4 articles | Viewed by 10489 | Submission Open

Keywords: rabies; zoonosis; vaccine; evolution; structural biology; viral replication; virus– host interaction; pathogenesis and immunity; clinical virology

(This special issue belongs to the Section General Virology)

Avian Reovirus

edited by

Sunil Mor

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4855 | Submission Open

Keywords: avian reovirus; pathogenesis; reassortment; virus evolution; vaccines

(This special issue belongs to the Section Animal Viruses)

Research and Clinical Application of Adenovirus (AdV), 3rd Edition

edited by

Julia Davydova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2013 | Submission Open

Keywords: adenovirus; gene therapy; cancer; oncolytic; vaccine; delivery

(This special issue belongs to the Section Human Virology and Viral Diseases)

Infectious Disease Epidemiology and Transmission Dynamics: 3rd Edition

edited by

Zhanwei Du

Lin Wang

Zeynep Ertem

Jose Luis Herrera Diestra

and

Yuan Bai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1572 | Submission Open

Keywords: infectious disease epidemiology; mathematical modeling; computational epidemiology; pharmaceutical interventions (e.g.; mass testing; vaccination and antiviral); infection and fatality burden; serology; phylogenetics and phylodynamics

(This special issue belongs to the Section General Virology)

Human Cytomegalovirus Therapeutic Strategies and Clinical Applications

edited by Ravit Arav-Boger

submission deadline 30 Nov 2025 | 1 articles | Viewed by 896 | Submission Open

Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Evolutionary Challenges of RNA Viruses: Insights from SARS-CoV-2 Variants and Emerging Respiratory Diseases

edited by

Ahmed El-Shamy

submission deadline 30 Nov 2025 | Viewed by 359 | Submission Open

Keywords: RNA viruses; evolution; influenza; SARS-CoV2; COVID-19; respiratory diseases

(This special issue belongs to the Section General Virology)

Enveloped and Non-Enveloped Virus Assembly

edited by

Schuyler van Engelenburg

submission deadline 30 Nov 2025 | Viewed by 160 | Submission Open

Keywords: virus assembly; viral host factors; virus methodology; virus egress; membrane remodeling; cellular imaging; virus budding and release; protein-protein interactions; genome packaging; viral capsid; assembly inhibitors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Peste Des Petits Ruminants (PPR): Progress and Efforts Toward 2030 Eradication

edited by

Satya Parida

and

Felix Njeumi

submission deadline 30 Nov 2025 | Viewed by 103 | Submission Open

Keywords: peste des petits ruminants virus (PPRV); PPR; PPR in sheep; goats; cattle; buffaloes; and wildlife; PPR vaccination strategy; diagnosis; surveillance; epidemiology; episystem; socioeconomics; transmission; pathogenesis; atypical hosts and wildlife hosts

(This special issue belongs to the Section Animal Viruses)

Cellular Mechanisms Regulating HIV Replication, 2nd Edition

edited by

Sergei Nekhai

submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open

Keywords: HIV-1; HIV-1 replication; host factors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section General Virology)

Virology Research in South Africa—from a Great Legacy to an Optimistic Future

edited by

Burtram C. Fielding

and

Ziyaad Valley-Omar

submission deadline 1 Dec 2025 | 8 articles | Viewed by 25206 | Submission Open

Keywords: SARS-CoV-2; other respiratory viruses; vaccines; HIV; antiviral resistance; zoonotic viruses; hepatitis viruses; enteric viruses; novel viruses/virus discovery

(This special issue belongs to the Section General Virology)

Structure-Based Antiviral Drugs and Vaccine Design

edited by

Shi-hua Xiang

and

Fengwei Bai

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2096 | Submission Open

Keywords: antiviral; structure based; AI-powered; drug design; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bioinformatics and Computational Approaches in Viral Genomics and Evolution 2025

edited by Camila Malta Romano, Mariana Severo Ramundo and Nilson Coimbra

submission deadline 16 Dec 2025 | 2 articles | Viewed by 1652 | Submission Open

Keywords: bioinformatics tools; genomic surveillance; viral evolution; computational genomics; host-pathogen interactions

(This special issue belongs to the Section General Virology)

Virology in Italy 2025—9th National Congress of the Italian Society for Virology

edited by

Enzo Tramontano

Arnaldo Caruso

Massimiliano Galdiero

Luisa Rubino

and

Gabriele Vaccari

submission deadline 20 Dec 2025 | Viewed by 128 | Submission Open

Keywords: Italy; emerging viruses; viral subversion of host cell processes; viruses of microbes; antivirals; vaccines; emerging methods in virology; RNA in virus infection; plant viruses; antiviral innate immunity; animal viruses; mycoviruses

(This special issue belongs to the Section General Virology)

Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons

edited by Ya-Fang Chiu and Bill Sugden

submission deadline 30 Dec 2025 | 2 articles | Viewed by 5746 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

RSV Epidemiological Surveillance: 2nd Edition

edited by Emanuele Castagno and Irene Raffaldi

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3230 | Submission Open

Keywords: respiratory syncytial virus (RSV); epidemiological surveillance; bronchiolitis; children; newborns; infants

(This special issue belongs to the Section Human Virology and Viral Diseases)

Immune Mechanisms Against Respiratory Viral Pathogens

edited by Telugu Akula Narasaraju and Sunil More

submission deadline 30 Dec 2025 | Viewed by 57 | Submission Open

Keywords: respiratory viral infections; innate and adaptive immunity; host– pathogen interactions; inflammatory response; therapeutic interventions

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV Reservoirs, Latency, and the Factors Responsible

edited by Yuyang Tang and

Mudit Tyagi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 17469 | Submission Open

Keywords: HIV; HIV latency; HIV persistence; HIV eradication; HIV cure; HIV vaccine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Microscopy Methods for Virus Research

edited by Krishanu Ray

submission deadline 31 Dec 2025 | 6 articles | Viewed by 15185 | Submission Open

Keywords: viruses; fluorescence imaging; single-molecule imaging; super-resolution imaging; intra-vital imaging; electron microscopy; Cryo-EM; Cryo-ET

(This special issue belongs to the Section General Virology)

Controlling Zoonotic Viral Diseases from One Health Perspective 2025

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11238 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

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