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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Epidemiology, Evolution, and Dispersion of Flaviviruses (2nd Edition)

edited by

Marta Giovanetti

Fernanda De Bruycker Nogueira

Ana Maria Bispo De Filippis

and

Anne Paiva

submission deadline 30 Apr 2026 | 5 articles | Viewed by 20866 | Submission Open

Keywords: flavivirus; evolution; genomic epidemiology; phylodynamics; transmission

(This special issue belongs to the Section Animal Viruses)

JC Polyomavirus

edited by

Sébastien Lhomme

and Anne-Sophie L'Honneur

submission deadline 30 Apr 2026 | 4 articles | Viewed by 10336 | Submission Open

Keywords: JC polyomavirus; progressive multifocal leukoencephalopathy (PML); neurotropic variants; viral genomic rearrangements

(This special issue belongs to the Section Human Virology and Viral Diseases)

Human Cytomegalovirus Therapeutic Strategies and Clinical Applications

edited by Ravit Arav-Boger

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3622 | Submission Open

Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Application of Plant Viruses in Biotechnology

edited by

Kathleen Hefferon

and

Srividhya Venkataraman

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3580 | Submission Open

Keywords: plant viruses; viral nanoparticles; plant viral vectors; biotechnological applications

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Plant Viral Pathogens: Innovations in Detection, Genetic Diversity, and Evolutionary Dynamics

edited by

Akhtar Ali

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3047 | Submission Open

Keywords: high-throughput sequencing; RT-PCR and qRT-PCR; genetic diversity; virus evolution; mutations; reassortment; recombination

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Viral Diseases of Major Crops

edited by Zaifeng Fan and Yan Shi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2467 | Submission Open

Keywords: viral infection; viral pathogenicity; virus movement; replication; RNA silencing suppressor; host response; host factors; molecular plant– virus– vector interactions

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Human T-Cell Leukemia Virus (HTLV) Infection and Treatment: 2nd Edition

edited by Cynthia A. Pise-Masison and Damian F. J. Purcell

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2433 | Submission Open

Keywords: HTLV; HTLV-associated myelopathy/tropical spastic paraparesis; adult T-cell leukemia/lymphoma; inflammation; neurodegeneration; therapeutics; infectious dermatitis; cancer; antiviral drugs

(This special issue belongs to the Section Human Virology and Viral Diseases)

Epidemiology of Zoonotic Virus Transmission: Pathways, Host Factors, and Public Health Strategies

edited by

Francisco José Nunes Antunes

and

Rita Cordeiro

submission deadline 30 Apr 2026 | 1 articles | Viewed by 595 | Submission Open

Keywords: zoonotic viruses; transmission pathways; host factors; public health strategies; one health

(This special issue belongs to the Section Animal Viruses)

Viral Strategies to Regulate Host Immunity or Signal Pathways, 2nd Edition

edited by

Bumsuk Hahm

submission deadline 30 Apr 2026 | Viewed by 446 | Submission Open

Keywords: virus– host interaction; viral immunity; viral pathogenesis; immune evasion; innate immunity; adaptive immunity; signal pathway

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Understanding and Control of Rice Viruses

edited by

Shuai Fu

Tong Zhang

and

Yi Xu

submission deadline 30 Apr 2026 | Viewed by 294 | Submission Open

Keywords: rice viruses; virus detection techniques; virus– host interactions; rice plant resistance to viruses; emerging rice viruses; viral epidemiology; viral diseases management; insect vectors; AI-driven rice virus detection and control

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

The Development of Universal Influenza Vaccines

edited by

Yao-Qing Chen

and

Lei Deng

submission deadline 30 Apr 2026 | Viewed by 208 | Submission Open

Keywords: universal influenza vaccine; influenza virus; broadly protective immunity; vaccine development; cross-reactive antibodies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Plant Virus Resistance—2nd Edition

edited by

Miguel A. Aranda

submission deadline 30 Apr 2026 | Viewed by 177 | Submission Open

Keywords: plant virus resistance mechanisms; resistance-breaking viral strains; genetic and molecular breeding; virus– host interactions; genome editing; virus susceptibility factors; plant virus ecology; plant virus host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Host-Targeting Antivirals: From Mechanism to Intervention

edited by

Stephan Pleschka

submission deadline 30 Apr 2026 | Viewed by 164 | Submission Open

Keywords: host-targeting antivirals; host receptors; signaling pathways; metabolic networks; transcription factors; treatment; clinical intervention practice; preclinical data; intervention strategy design; mechanism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Immune Mechanisms Against Respiratory Viral Pathogens

edited by Telugu Akula Narasaraju and Sunil More

submission deadline 30 Apr 2026 | Viewed by 159 | Submission Open

Keywords: respiratory viral infections; innate and adaptive immunity; host– pathogen interactions; inflammatory response; therapeutic interventions

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Apr 2026 | Viewed by 140 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section General Virology)

Respiratory Syncytial Virus: Pathogenesis, Prevention and Treatment

edited by

Javier de Miguel-Díez

submission deadline 30 Apr 2026 | Viewed by 129 | Submission Open

Keywords: respiratory syncytial virus (RSV); RSV infection; pathogenesis; RSV prevention; RSV treatment; vaccines

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus-Associated Nephropathies

edited by Rajendra Bhimma and

Sudesh Hariparshad

submission deadline 30 Apr 2026 | Viewed by 113 | Submission Open

Keywords: viruses; kidney; nephropathy; immunosuppressed; pathogenesis; BK polyomavirus; COVID-19; HIV-associated nephropathy (HIVAN); diagnostic advances; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Antigen Discovery and Design for Veterinary Viral Vaccines

edited by

Levon Abrahamyan

and

Hiep Vu

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: antigen discovery; antigen design; reverse/structural vaccinology; immunoinformatics; epitope mapping (B/T); vaccines; adjuvants; VLP/nanoparticle platforms; mRNA/DNA vaccines; DIVA

(This special issue belongs to the Section Animal Viruses)

Iridoviruses, 3rd Edition

edited by

Jian Zhang

and

Thomas B. Waltzek

submission deadline 30 Apr 2026 | Viewed by 76 | Submission Open

Keywords: iridovirus; viral immune evasion; anti-viral immune responses; viral vaccine; viral pathogenesis; viral epidemiology

(This special issue belongs to the Section Animal Viruses)

Physical Virology—Viral Ways for Navigating the Space Mesoscale

edited by Bogdan G. Dragnea

submission deadline 30 Apr 2026 | Viewed by 62 | Submission Open

Keywords: virus mechanics; virus acoustic modes; virus assembly thermodynamics; virus assembly kinetics; protein shell symmetry; virus-like particle applications; virus– interface interactions

(This special issue belongs to the Section General Virology)

Coxsackieviruses, Polioviruses and Associated Diseases (Second Edition)

edited by

Yong Zhang

and

Didier Hober

submission deadline 1 May 2026 | 10 articles | Viewed by 18908 | Submission Open

Keywords: coxsackievirus; HFMD; viral Meningitis; myocarditis; pericarditis; herpangina; poliovirus; poliomyelitis; acute flaccid paralysis; post-polio syndrome; pleurodynia (Bornholm disease)

(This special issue belongs to the Section Human Virology and Viral Diseases)

Control and Contributions of Transposable Elements: Implications for Development and Disease

edited by Suzanne B. Sandmeyer and Henry L. Levin

submission deadline 1 May 2026 | Viewed by 344 | Submission Open

Keywords: transposable elements; endogenous viruses; transcription factors; neurotransmission; aging

(This special issue belongs to the Section General Virology)

Viral Genetic Variability and Its Role in Assessing Infectious Diseases

edited by

Fabio Scarpa

and

Francesco Branda

submission deadline 6 May 2026 | 2 articles | Viewed by 2040 | Submission Open

Keywords: viral genetic diversity; infectious diseases; viral evolution; host adaptation; next-generation sequencing; pathogenicity; immune evasion; viral surveillance; bioinformatics; genetic variability; phylogeny; phylodynamics

(This special issue belongs to the Section General Virology)

Viral RNA and Its Interaction with the Host

edited by

Redmond Smyth

and Neva Caliskan

submission deadline 15 May 2026 | 6 articles | Viewed by 11008 | Submission Open

Keywords: virus life cycle; host-virus interactions; viral RNA; RNA structures; RNA binding proteins; translational control; RNA modifications; immune evasion; RNA localization

(This special issue belongs to the Section General Virology)

Multiscale Modeling and Forecasting of COVID-19 and Respiratory Virus Dynamics

edited by

Gerardo Chowell

and Sunmi Lee

submission deadline 15 May 2026 | 4 articles | Viewed by 3127 | Submission Open

Keywords: COVID-19 modeling; respiratory virus dynamics modeling; epidemic forecasting; parameter identifiability; multiscale transmission dynamics

(This special issue belongs to the Section General Virology)

Virus Infections and Host Metabolism 2025

edited by

Kuan Rong Chan

Yaw Shin Ooi

and Liang Cui

submission deadline 15 May 2026 | Viewed by 654 | Submission Open

Keywords: host– virus interactions; host response to viruses; immunometabolism; viral pathogenesis; metabolic reprogramming; metabolome; metabolism; lipidomics

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Conquering Antiviral Drug Resistance via Development of Novel Antivirals and New Testing Methods for Drug Resistance: From Bench to Bedside

edited by

Benjamin M. Liu

Jun Wang

and David Hillyard

submission deadline 15 May 2026 | Viewed by 533 | Submission Open

Keywords: antivirals; viral hepatitis; HIV; Mpox; influenza; enterovirus; chronic viral infections; acute viral infections; diagnosis; antiviral drug resistance; antiviral drug mutations; antiviral drug development; viral evolution; treatment

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Opportunistic Viral Infections, 3rd Edition

edited by

Carlo Contini

submission deadline 15 May 2026 | 1 articles | Viewed by 233 | Submission Open

Keywords: epidemiology of opportunistic viral infections; immunocompromised individuals (HIV/AIDS; transplants; tumors; chemotherapeutics; biotechnological drugs; etc.); advances in diagnosis; management and treatment of opportunistic viral infections; JC virus; HPV; CMV; EBV and other herpesvirus; human T-cell leukemia virus type 1 (HTLV-1); hepatitis B virus (HBV) and hepatitis C virus (HCV); polyomavirus; new Coronavirus including SARS-CoV-2; emerging viruses (arbovirus other zoonotic virus)

(This special issue belongs to the Section General Virology)

Nasal Immunity Against Virus Infection

edited by

Federica Novazzi

submission deadline 15 May 2026 | Viewed by 25 | Submission Open

Keywords: virus– host; viral life cycle; viral replication; imaging; respiratory viruses; nasal immunology; type-I interferon; type-III interferon; proinflammatory cytokines; age; viral load

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Research and Clinical Application of Adenovirus (AdV), 3rd Edition

edited by

Julia Davydova

submission deadline 20 May 2026 | 3 articles | Viewed by 5549 | Submission Open

Keywords: adenovirus; gene therapy; cancer; oncolytic; vaccine; delivery

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cellular Mechanisms Regulating HIV Replication, 2nd Edition

edited by

Sergei Nekhai

submission deadline 20 May 2026 | 1 articles | Viewed by 1270 | Submission Open

Keywords: HIV-1; HIV-1 replication; host factors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Influenza B Virus: From Infection to Prevention

edited by Saira Hussain

submission deadline 30 May 2026 | Viewed by 375 | Submission Open

Keywords: influenza B viruses; epidemiology; evolution; pathogenesis; immunity; vaccine; antivirals

(This special issue belongs to the Section Animal Viruses)

Innate and Adaptive Immune Responses to Arbovirus Infections

edited by Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes and

Rafael Freitas de Oliveira França

submission deadline 31 May 2026 | 4 articles | Viewed by 14581 | Submission Open

Keywords: arbovirus; innate immunity; adaptive immunity; immunotherapeutic; immunoprophylaxis; vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV Neurological Disorders: 2nd Edition

edited by

Frank Denaro

submission deadline 31 May 2026 | 3 articles | Viewed by 8806 | Submission Open

Keywords: neuroinflammation; chronic HIV inflammation; HIV reservoir; HIV proteins; HIV receptors; HIV models; drugs of abuse; AIDS dementia complex; HIV noninfectious comorbidities; HIV healthcare disparities; HIV neuropathology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Mechanisms of Immune Evasion

edited by

Xiaoyong Bao

submission deadline 31 May 2026 | 4 articles | Viewed by 8457 | Submission Open

Keywords: immune evasion; virulent factor; antiviral signaling; pathogenesis; antiviral strategy

(This special issue belongs to the Section General Virology)

Emerging and Re-Emerging Viral Zoonoses

edited by

Lorena Jemeršić

and

Margarida Simões

submission deadline 31 May 2026 | 3 articles | Viewed by 5422 | Submission Open

Keywords: epidemiology of emerging and re-emerging viral zoonoses; zoonotic spillover; viral evolution; animal reservoirs; zoonotic transmission; animals as sentinels of viral zoonoses and risk analyses; diagnostic novelties and early detection of viral threats; viral genomics and molecular epidemiology; viral pathogenesis; viral adaptation mechanisms; wildlife– human interface; monkeypox virus (mpxv); influenza viruses; nipah virus; ebola/marburg virus; hantavirus; crimea-congo virus; vaccine development; therapeutic and mitigation strategies; climate change; biodiversity loss and infectious diseases

(This special issue belongs to the Section Animal Viruses)

Emerging Concepts in SARS-CoV-2 Biology and Pathology, 3rd Edition

edited by

Daniele Focosi

submission deadline 31 May 2026 | 4 articles | Viewed by 4440 | Submission Open

Keywords: SARS-CoV-2; epidemiology; virology; therapeutics; zoonoses

(This special issue belongs to the Section Coronaviruses)

Peste Des Petits Ruminants (PPR): Progress and Efforts Toward 2030 Eradication

edited by

Satya Parida

and

Felix Njeumi

submission deadline 31 May 2026 | 1 articles | Viewed by 3780 | Submission Open

Keywords: peste des petits ruminants virus (PPRV); PPR; PPR in sheep; goats; cattle; buffaloes; and wildlife; PPR vaccination strategy; diagnosis; surveillance; epidemiology; episystem; socioeconomics; transmission; pathogenesis; atypical hosts and wildlife hosts

(This special issue belongs to the Section Animal Viruses)

Roles of Macrophages in Viral Infections, 2nd Edition

edited by

Stefano Aquaro

submission deadline 31 May 2026 | 2 articles | Viewed by 3198 | Submission Open

Keywords: macrophage; microglia; Kupffer cells; viral infection; antiviral immunity; inflammatory cytokines; langerhans cell; antiviral drugs; viral pathogenesis

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Molecular and Biological Virus-Plant-Insect Vector Interactions

edited by Yong Liu

submission deadline 31 May 2026 | 2 articles | Viewed by 2792 | Submission Open

Keywords: plant virus transmission; virus– plant interactions; virus– vector interactions; virus– vector– plant interactions; epidemiology of virus transmission; molecular mechanisms; viral manipulation; diagnostic techniques

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Citrus Viral Diseases: Advances in Knowledge and Technologies and Their Containment Measures

edited by

Antonino F. Catara

Salvatore Davino

and Moshe Bar-Joseph

submission deadline 31 May 2026 | 1 articles | Viewed by 2173 | Submission Open

Keywords: citrus viruses; genomic characterization; diagnostics; vector; virus– insect interactions; viral and virus-like pathogens

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Biosecurity and Plant Viruses: A Call to Action for a Sustainable Future

edited by

Yi Xu

and

Patricia Valle Pinheiro

submission deadline 31 May 2026 | 2 articles | Viewed by 1962 | Submission Open

Keywords: biosecurity; viral disease; sustainable agriculture; emerging plant viruses; quarantine regulations

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Current: Measles Outbreak, a Global Situation

edited by

S. Louise Cosby

submission deadline 31 May 2026 | 1 articles | Viewed by 1906 | Submission Open

Keywords: measles; vaccination; surveillance; complications; outbreaks

(This special issue belongs to the Section Human Virology and Viral Diseases)

Animal Models in Emerging/Re-Emerging Infectious Diseases

edited by Dong Yang

submission deadline 31 May 2026 | 1 articles | Viewed by 1535 | Submission Open

Keywords: emerging/re-emerging infectious diseases; animal models; pathogen– host interactions; pathogenesis; interventions; drugs; vaccines

(This special issue belongs to the Section Animal Viruses)

Interferon-Stimulated Genes in Antiviral Immunity

edited by

Chen Liang

submission deadline 31 May 2026 | 1 articles | Viewed by 530 | Submission Open

Keywords: interferon-stimulated genes; ISGs; non-coding RNA; viral replication; deep learning tools

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

West Nile Virus 2025

edited by Orsolya Korbacska-Kutasi and Gábor Kemenesi

submission deadline 31 May 2026 | Viewed by 494 | Submission Open

Keywords: West Nile virus; epidemiology; surveillance; biology; evolution; pathogenesis; vaccine development; antiviral therapies

(This special issue belongs to the Section Animal Viruses)

Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

edited by

Remi N. Charrel

submission deadline 31 May 2026 | Viewed by 256 | Submission Open

Keywords: basic sciences; social sciences; epidemiology; climate studies; clinical studies; diagnostics; serology; molecular detection; entomology; antivirals; vaccines; infection control; nosocomial; transmission; pathogenesis; virulence; taxonomy; genomics

(This special issue belongs to the Section Animal Viruses)

Canine Distemper Virus: 2nd Edition

edited by Monica G. Candela and

Nieves Ortega Hernández

submission deadline 31 May 2026 | Viewed by 164 | Submission Open

Keywords: CDV taxonomy (lineages); new hosts of CDV; CDV pathogenesis; CDV epidemiology (risk factors; distribution; and prevalence); CDV prevention/risk mitigation

(This special issue belongs to the Section Animal Viruses)

Hepatitis Virus Genetic Heterogeneity: Impact in Epidemiology and Clinical Pathology

edited by

Livia Melo Villar