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Special Issue "Therapeutic Vaccines and Cancer Immunotherapy"
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (31 May 2018) | Viewed by 52151
Special Issue Editor
Interests: cancer immunotherapy; therapeutic vaccines; HPV; Hepatitis C virus; intratumoral immune environment; alphavirus-based vaccines
Special Issue Information
In this Special Issue of Vaccines, we will focus on strategies based on cancer vaccines, either as single agent treatments or combined with other therapeutic cancer treatments. A multitude of cancer vaccines have shown promising results in preclinical studies, but so far only one cancer vaccine is FDA approved. This is remarkable given the fact that in general antigen-specific immune cells are elicited, also in clinical trials. One can envision several reasons for the somewhat limiting clinical results. Reasons that put forward new challenges to achieve clinical effective therapeutic cancer vaccines. First, limited clinical responses may be due to insufficient or inappropriate activation of antigen-specific immune effector cells in cancer patients due to immune tolerance and immune suppression. Second, therapeutic efficacy might be hampered by the immune suppressive microenvironment in the tumor. Immune-effector cells may either be unable to accumulate into tumors or are inactivated rapidly upon infiltrating into a tumor. Thus, research on further improvements to pre-emptively increase the chance of therapeutic efficacy of cancer vaccines in the clinic is still essential.
It is becoming increasingly more apparent that, as part of the design of vaccine regimens, combination therapy might be a better treatment option compared to monotherapy for durable clinical responses. Combination regimens currently being explored include differing immunotherapeutic approaches including vaccines combined with conventional chemotherapy and radiation therapy. A more in-depth understanding on effects of dosing and scheduling of these treatments is required for a rational design of therapeutic combinations. In addition, especially in this era of check-point blockade immunotherapy and targeted therapies, cancer vaccines are regaining major clinical interest, as induction and/or expansion of tumor-specific immune effector cells will be vital to further enhance and broaden the efficacy and applicability of these forms of cancer immunotherapies.
In this Special Issue, we hope to provide an overview on novel or optimized cancer vaccines and rational combination therapies that aim to further enhance numbers, activity and recruitment of immune effector cells in the tumor microenvironment.Prof. Dr. C.A.H.H. (Toos) Daemen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Therapeutic cancer vaccine
- Vaccine optimization
- Immune cell infiltration
- Cancer immunotherapy
- Combination therapies
- Anti-tumor activity
- Tumor suppression
- Check point blockade
- Targeted therapies