Immune Checkpoint Inhibitor-Based Immunotherapy in Cancer: Predictive Biomarkers and Mechanisms of Resistance

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cancer Vaccines and Immunotherapy".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1850

Special Issue Editor


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Guest Editor
EA4340-BCOH, Biomarker in Cancerology and Onco-Haematology, Université de Versailles-Saint-Quentin-En-Yvelines, Université Paris Saclay, 92100 Boulogne-Billancourt, France
Interests: immunotherapy; immunology; cancer and cell biology; targeted therapies; biomarkers; developmental pathways
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Special Issue Information

Dear Colleagues,

The use of immune checkpoint inhibitors (ICIs) including anti-PDL-1/PD-1 (Pembroluzimab, nivolumab, atezolizumab, avelumab, durvalumab), and anti-CTL4 (Ipilimumab), has shown promising results in various types of refractory solid and hematological malignancies such as melanoma, lung cancers, leukemia, and lymphoma. To fully exploit the potential of ICIs and uncover why some patients are still refractory to these promising drugs, studies are implemented to understand the molecular and cellular mechanisms related to ICI resistance or efficacy.

This Special Issue aims to address the latest findings related to the use of ICI-based immunotherapy in cancer, including treatment schedule, mechanisms of ICIs resistance, and predictive biomarkers.

Submissions of original articles, systematic reviews, short communications, and other types of articles on related topics are welcome. All manuscripts will follow the standard journal peer review practices, and those accepted for publication will appear in this Special Issue on “Immune-Checkpoints-Based Immunotherapy in Cancer: Predictive Biomarkers and Mechanisms of Resistance”. We look forward to receiving your contributions.

You may choose our Joint Special Issue in Cancers.

Dr. Paul Takam Kamga
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer
  • immunotherapy
  • ICIs
  • immuno-resistance
  • predictive biomarkers

Published Papers (1 paper)

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Research

13 pages, 1263 KiB  
Article
A Clinical Analysis of Anti-Programmed Death-Ligand 1 (PD-L1) Immune Checkpoint Inhibitor Treatments Combined with Chemotherapy in Untreated Extensive-Stage Small-Cell Lung Cancer
by Ping-Chih Hsu, Bing-Chen Wu, Chin-Chou Wang, Li-Chung Chiu, Chiung-Hsin Chang, Ping-Chi Liu, Chiao-En Wu, Scott Chih-Hsi Kuo, Jia-Shiuan Ju, Allen Chung-Cheng Huang, Yu-Ching Lin, Cheng-Ta Yang and How-Wen Ko
Vaccines 2024, 12(5), 474; https://doi.org/10.3390/vaccines12050474 - 29 Apr 2024
Viewed by 1103
Abstract
Real-world clinical experience of using anti-programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs) combined with chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer (SCLC) patients has rarely been reported. In this study, we aimed to perform a retrospective multicenter clinical analysis [...] Read more.
Real-world clinical experience of using anti-programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs) combined with chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer (SCLC) patients has rarely been reported. In this study, we aimed to perform a retrospective multicenter clinical analysis of extensive-stage SCLC patients receiving first-line therapy with anti-PD-L1 ICIs combined with chemotherapy. Between November 2018 and March 2022, 72 extensive-stage SCLC patients receiving first-line atezolizumab or durvalumab in combination with chemotherapy, according to the cancer center databases of Linkou, Chiayi, and Kaohsiung Chang Gung Memorial Hospitals, were retrospectively included in the analysis. Twenty-one patients (29.2%) received atezolizumab and fifty-one (70.8%) received durvalumab. Objective response (OR) and disease control (DC) rates of 59.7% and 73.6%, respectively, were observed with first-line ICI plus chemotherapy. The median progression-free survival (PFS) was 6.63 months (95% confidence interval (CI), 5.25–8.02), and the median overall survival (OS) was 16.07 months (95% CI, 15.12–17.0) in all study patients. A high neutrophil-to-lymphocyte ratio (NLR; >4) and a high serum lactate dehydrogenase (LDH) concentration (>260 UL) were identified as independent unfavorable factors associated with shorter OS in the multivariate analysis. Regarding safety, neutropenia was the most common grade 3 treatment-related adverse event (AE), but no treatment-related deaths occurred in the study patients. First-line anti-PD-L1 ICIs combined with chemotherapy are effective and safe for male extensive-stage SCLC patients. Further therapeutic strategies may need to be developed for patients with unfavorable outcomes (e.g., baseline high NLR and serum LDH level). Full article
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