Immunity, Immunoprevention and Immunotherapy in Cancer and Viral Diseases
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 25079
Special Issue Editors
Interests: cancer and antiviral immunotherapy; radiation-mediated immune responses against cancer; immune responses to viral infections
Special Issue Information
Dear Colleagues,
The mechanisms involved in innate and adaptive immune responses that promote or inhibit tumor progression are well described. Similarly, in viral infections, these responses either eliminate the virus after infection or intrinsic and extrinsic factors lead to chronic disease. Persistent antigen stimulation and severe inflammation in chronic viral infections or cancer result in T cell exhaustion and dysfunction, which in part contributes to severe disease outcomes. Exhausted T cells manifest diminished effector function and proliferative potential, as they overexpress multiple inhibitory receptors, such as programmed cell death (PD)-1 and cytotoxic T lymphocyte antigen (CTLA)-4. These check-point molecules are among a long list of effective targets in cancer treatments, and their blockade reinvigorates dysfunctional T cells, thus, restoring anti-tumor immune responses. These immunotherapies have raised overall survival for various cancers to significant levels. However, some cancer aetiologies and even some patients with sensitive cancer types do not respond to these therapies or develop resistance after initial responsiveness. There is an urgent need to identify novel cancer/viral treatments, decipher mechanisms of resistance to immune-therapeutics, and to develop novel combination therapies and tumor vaccine strategies.
Research papers, reviews, and commentaries in this Special Issue will highlight mechanisms of novel immunotherapies, combination therapies, mechanisms of T cell exhaustion, and the role and function of different immune cells in chronic viral infections and cancer. Studies focussing on cancer vaccines are also welcome.
Dr. Tahseen H. Nasti
Dr. Christiane Eberhardt
Guest Editors
Manuscript Submission Information
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Keywords
- anti-tumor responses
- immune therapies
- T cell exhaustion
- check-point inhibitors
- chronic viral infections
- cancer vaccines
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