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Review

Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer

1
Department of Oncology, University of Lausanne, 1006 Epalinges, Switzerland
2
Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland
3
Ludwig Institute for Cancer Research, Lausanne Branch, 1006 Epalinges, Switzerland
*
Author to whom correspondence should be addressed.
Equal contribution.
Academic Editor: Giampiero Girolomoni
Vaccines 2021, 9(5), 454; https://doi.org/10.3390/vaccines9050454
Received: 1 April 2021 / Revised: 29 April 2021 / Accepted: 2 May 2021 / Published: 4 May 2021
Immunotherapy has become a standard treatment in many cancers and it is based on three main therapeutic axes: immune checkpoint blockade (ICB), vaccination and adoptive cell transfer (ACT). If originally these therapies mainly focused on exploiting CD8 T cells given their role in the direct elimination of tumor cells, increasing evidence highlights the crucial role CD4 T cells play in the antitumor immune response. Indeed, these cells can profoundly modulate the tumor microenvironment (TME) by secreting different types of cytokine or by directly eliminating cancer cells. In this review, we describe how different CD4 T cell subsets can contribute to tumor immune responses during immunotherapy and the novel high-throughput immune monitoring tools that are expected to facilitate the study of CD4 T cells, at antigen-specific and single cell level, thus accelerating bench-to-bed translational research in cancer. View Full-Text
Keywords: CD4 T cells; immunotherapy; antigen-specific; cancer; immune monitoring CD4 T cells; immunotherapy; antigen-specific; cancer; immune monitoring
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MDPI and ACS Style

Saillard, M.; Cenerenti, M.; Romero, P.; Jandus, C. Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer. Vaccines 2021, 9, 454. https://doi.org/10.3390/vaccines9050454

AMA Style

Saillard M, Cenerenti M, Romero P, Jandus C. Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer. Vaccines. 2021; 9(5):454. https://doi.org/10.3390/vaccines9050454

Chicago/Turabian Style

Saillard, Margaux, Mara Cenerenti, Pedro Romero, and Camilla Jandus. 2021. "Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer" Vaccines 9, no. 5: 454. https://doi.org/10.3390/vaccines9050454

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