The 3rd Edition: Development of Vaccines Based on Virus-Like Particles

Dear Colleagues,

Basic studies on virus structure and assembly have led to the experimental observation that many viral structural proteins have the intrinsic ability to self-assemble into virus-like particles (VLPs). These VLPs have led to better immunological mimics of whole-virus particles compared to soluble capsid subunits, resulting in the improved effectiveness of vaccines and leading to a renaissance in vaccine development.

VLP-based vaccines combine many of the advantages of whole-virus-based and recombinant subunit vaccines, exhibiting a high safety profile. VLPs produced using recombinant protein expression systems can stimulate strong B- and T-cell immune responses and have been shown to exhibit self-adjuvanting abilities. In addition, VLPs can be used as platforms for the multimeric display of foreign antigens of interest derived from viruses or other pathogens (chimeric VLPs).

This Special Issue aims to collect recent research work on the design, generation and use of VLPs and chimeric VLPs for the development of both human and veterinary new generation vaccines.

Dr. Esther Blanco
Dr. Juan Bárcena
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• virus-like particles
• VLPs
• chimeric VLPs
• conjugated VLPs
• virosomes
• nanoparticles
• nanocarriers
• prophylactic vaccines
• therapeutic vaccines
• multimeric presentation

• Development of Vaccines Based on Virus-Like Particles in Vaccines (17 articles)
• Development of Vaccines Based on Virus-Like Particles-2nd Edition in Vaccines (9 articles)