Adjuvants and Antigen Delivery Systems for Tuberculosis Subunit Vaccines

Dear Colleagues,

The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, specially pulmonary disease in adults. The research towards development of new vaccines against TB includes the use of M. tuberculosis antigens as subunit vaccines. Such vaccines may be used either alone or in prime-boost model in BCG-vaccinated people. However, the antigens for subunit vaccines require adjuvants and/or delivery systems to induce appropriate and protective immune responses.  This special issue will focus on the use of different adjuvants and delivery systems, e.g. chemical adjuvants, liposomes,  nanoparticles, naked DNA, and viral and bacterial vectors, etc. in inducing the protective immune responses after immunization with subunit vaccines. The issue will include manuscripts related to the research in animal models and clinical trials in humans. 

Prof. Dr. Abu Mustafa
Guest Editor