Tuberculosis Vaccines

Dear Colleagues,

Tuberculosis is a major health problem of global concern. According to estimates from the World Health Organization, one-third of the world population is infected with Mycobacterium tuberculosis, over 9 million people develop active disease and 2 million people die of tuberculosis each year. To immunize against tuberculosis, routine vaccination with Mycobacterium bovis BCG is practiced in many countries. Although, BCG vaccine offers some protection against childhood tuberculosis and severe forms of the disease in adults, it has failed to provide consistent protection against pulmonary disease in adults, which is the major manifestation of tuberculosis. Investigators are attempting to develop improved vaccines against tuberculosis by genetic manipulation of BCG, identifying M. tuberculosis auxotroph and protein antigens as subunit vaccines, etc. This Special Issue on “Tuberculosis Vaccines”  will highlight leading developments in the vaccine technology, including but not limited to, genetically modified BCG, M. tuberculosis-derived vaccines, subunit (proteins/peptide, DNA and recombinant) vaccines, and their validation in animal models. Novel mechanisms of enhancing vaccine efficacy are also welcome including research on adjuvants and biomarkers of protection against tuberculosis. The Special Issue will be a mix of original research articles, and mini reviews. The main focus of this Special Issue is to present cutting edge research and recent developments in vaccines, which can prevent tuberculosis in mankind.

We look forward to reading your contributions

Prof. Dr. Chinnaswamy Jagannath
Prof. Dr. Abu Salim Mustafa
Guest Editors

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