Special Issue "The Past and Present Threat of Rickettsial Diseases"
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366).
Deadline for manuscript submissions: closed (31 May 2018).
2. Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420/6 Ratchawithi Rd., Ratchathewi District, Bangkok 10400, Thailand
3. Swiss Tropical and Public Health Institute, Basel, Switzerland
4.University Basel, Basel, Switzerland
Interests: rickettsia; scrub typhus; murine typhus; diagnostics; pathophysiology; vaccine; host response and immune response
Tropical rickettsial illnesses are severely neglected tropical diseases of substantial impact on both rural and urban populations. For scrub typhus, all countries with established surveillance systems—available for South Korea, Japan, China, and Thailand—report increasing minimum incidence rates over the past decade. Recent reports from South America and Africa suggest a wider distribution outside Asia. It is a potentially severe disease, with mortality reports around a median mortality of 6.0% for untreated and 1.4% for treated scrub typhus. For murine typhus, an equally important and even more neglected disease with a more urban distribution, a lot of clinically relevant information on the natural history, disease burden, diagnostics and pathogen characterisation are lacking. Scrub typhus and murine typhus together are responsible for a substantial proportion of undiagnosed febrile illnesses in humans in many parts of the tropics.
Unfortunately, there are many limitations on the amount and quality of available epidemiological data, limited conclusions, mathematical modeling, or mapping approaches. Further, the control of these vector-borne diseases is challenging due to humans being dead-end hosts, vertical maintenance of the pathogen in the vector itself, a potentially large rodent reservoir of unclear significance, coupled with non-specific clinical features upon presentation and diagnostic difficulties.
In this Special Issue of “Tropical Medicine and Infectious Disease”, we invite the submission of reviews, reports and original research articles on the currently relevant aspects of tropical rickettsial illnesses—with emphasis on diagnostic developments, epidemiology, fever studies, bacterial virulence, genomics and potential antimicrobial resistance issues—aiming at improving the awareness and understanding of physicians and researchers alike, about these neglected but important diseases.
Prof. Daniel H. Paris
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- Tropical rickettsial illnesses
- Scrub typhus
- Murine typhus
- Spotted fever group rickettsiae
- Orientia tsutsugamushi
- Trombiculid mites
- Fleas and ticks
- Cell biology
- Unraveling genomic issues
- Aetiology of fever studies