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Special Issue "Toxins and Virulence Factors of Listeria monocytogenes"
Deadline for manuscript submissions: 15 February 2020.
Interests: Host-pathogen interactions; Bacterial virulence factors; bacterial pore forming toxins, Listeria monocytogenes
Listeria monocytogenes is a major intracellular foodborne bacterial pathogen which causes listeriosis, a human systemic infection. Among zoonotic diseases under EU-surveillance, listeriosis is the most severe. L. monocytogenes can grow under temperatures ranging from 0 to 45°C, in acidic medium and at high osmolarity; conditions that it may encounter in nature, in the food chain, as well as during infection. L. monocytogenes has the capacity to colonize various niches, from inert and organic matrixes to the intestinal lumen where it competes with resident microbiota, translocates across the epithelium, multiplies in phagocytic and non-phagocytic cells, and disseminates via the blood. To adapt and resist to this diversity of environments, L. monocytogenes evolved an arsenal of virulence mechanisms spatially and timely regulated.
Toxins are essential determinants of bacterial virulence. The cholesterol-dependent cytotoxin Listeriolysin O (LLO) is a major L. monocytogenes virulence factor that mediates the escape of bacteria from internalization vacuoles, allowing replication in the cytosol. Other L. monocytogenes toxins have been described to date, including phospholipases (PlcA, PlcB) that contribute to the escape from the endocytic and secondary vacuoles, the thiazole/oxazole-modified toxin Listeriolysin S (LLS) that behaves as a bacteriocin favoring intestinal colonization, or the toxin/antitoxin MazEF involved in growth and survival under stress. In addition, several L. monocytogenes secreted or surface-associated proteins play major roles in virulence.
The L. monocytogenes genome encodes a large number of proteins of still unknown functions; some of them are probably undiscovered virulence factors. This Special Issue focuses on the role of known or new L. monocytogenes determinants acting as offensive or defensive factors but providing benefits to bacterial virulence, with a special emphasis on toxins and secreted or surface proteins. Original research manuscripts, methods, opinions, reviews, and mini reviews are welcome.
Dr. Didier Cabanes
Dr. Sandra Sousa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Listeria monocytogenes
- Virulence factors
- Surface proteins
- Secreted proteins
- Host-pathogen interactions