Special Issue "Toxin-Antibody Interactions"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 January 2014)
Dr. Nicholas J. Mantis
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
Phone: +1 518 473 7487
Fax: +1 518 402 4773
Interests: plant and bacterial protein toxins; neutralizing antibodies; vaccines; mucosal tissues; animal models; small molecule inhibitors
Antibodies are remarkable in their ability to inactivate even the most potent plant and microbial toxins, including botulinum, tetanus, diphtheria, anthrax and ricin toxins. While this fact has been recognized for more than a century, surprisingly little is known about the molecular mechanisms by which antibodies actually neutralize toxins. Indeed, historically, there has been little incentive to investigate the nature of toxin-antibody interactions because of the success of so many toxin vaccines and therapies. However, this has changed in the past decade with the global demand in the public health and biodefense sectors for new generation antibody-based countermeasures that are safer and more effective. With the surge in new research, it is now becoming increasingly apparent that the interactions between toxins-antibodies are as complex, sophisticated and interesting as the toxins themselves.
The goal of this special issue of Toxins is to provide a state-of-the-art look into the diverse mechanisms by which antibodies neutralize toxins and insights into how understanding these interactions will have applications for next generation vaccines and therapeutics.
Dr. Nicholas J. Mantis
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.
Article: Recombinant Clostridium difficile Toxin Fragments as Carrier Protein for PSII Surface Polysaccharide Preserve Their Neutralizing Activity
Toxins 2014, 6(4), 1385-1396; doi:10.3390/toxins6041385
Received: 6 February 2014; in revised form: 6 March 2014 / Accepted: 9 April 2014 / Published: 22 April 2014| Download PDF Full-text (471 KB) | View HTML Full-text | Download XML Full-text
Toxins 2014, 6(4), 1325-1348; doi:10.3390/toxins6041325
Received: 10 February 2014; in revised form: 10 March 2014 / Accepted: 28 March 2014 / Published: 11 April 2014| Download PDF Full-text (2499 KB) | Download XML Full-text
Toxins 2014, 6(1), 380-393; doi:10.3390/toxins6010380
Received: 10 December 2013; in revised form: 10 January 2014 / Accepted: 10 January 2014 / Published: 21 January 2014| Download PDF Full-text (552 KB) | View HTML Full-text | Download XML Full-text
Review: Towards Clinical Applications of Anti-endotoxin Antibodies; A Re-appraisal of the Disconnect
Toxins 2013, 5(12), 2589-2620; doi:10.3390/toxins5122589
Received: 31 October 2013; in revised form: 9 December 2013 / Accepted: 13 December 2013 / Published: 18 December 2013| Download PDF Full-text (462 KB) | View HTML Full-text | Download XML Full-text
Article: Cloning and Characterization of a Hybridoma Secreting a 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Specific Monoclonal Antibody and Recombinant F(ab)
Toxins 2013, 5(3), 568-589; doi:10.3390/toxins5030568
Received: 9 January 2013; in revised form: 28 February 2013 / Accepted: 5 March 2013 / Published: 19 March 2013| Download PDF Full-text (785 KB) | View HTML Full-text | Download XML Full-text
Toxins 2012, 4(12), 1565-1581; doi:10.3390/toxins4121565
Received: 22 November 2012; in revised form: 13 December 2012 / Accepted: 13 December 2012 / Published: 19 December 2012| Download PDF Full-text (562 KB) | View HTML Full-text | Download XML Full-text
Article: MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen
Toxins 2012, 4(12), 1451-1467; doi:10.3390/toxins4121451
Received: 22 August 2012; in revised form: 16 November 2012 / Accepted: 28 November 2012 / Published: 5 December 2012| Download PDF Full-text (330 KB) | View HTML Full-text | Download XML Full-text
Article: Interaction between Shiga Toxin and Monoclonal Antibodies: Binding Characteristics and in Vitro Neutralizing Abilities
Toxins 2012, 4(9), 729-747; doi:10.3390/toxins4090729
Received: 28 August 2012; in revised form: 17 September 2012 / Accepted: 17 September 2012 / Published: 18 September 2012| Download PDF Full-text (1379 KB) | View HTML Full-text | Download XML Full-text
Article: Humanized-Single Domain Antibodies (VH/VHH) that Bound Specifically to Naja kaouthia Phospholipase A2 and Neutralized the Enzymatic Activity
Toxins 2012, 4(7), 554-567; doi:10.3390/toxins4070554
Received: 19 June 2012; in revised form: 26 June 2012 / Accepted: 6 July 2012 / Published: 19 July 2012| Download PDF Full-text (1125 KB) | View HTML Full-text | Download XML Full-text | Supplementary Files
Toxins 2012, 4(6), 430-454; doi:10.3390/toxins4060430
Received: 29 April 2012; in revised form: 6 June 2012 / Accepted: 7 June 2012 / Published: 11 June 2012| Download PDF Full-text (526 KB) | View HTML Full-text | Download XML Full-text
Last update: 4 March 2014