Toxin-Antibody Interactions
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 January 2014) | Viewed by 102887
Special Issue Editor
Interests: plant and bacterial toxins; antibodies; vaccines; pathophysiology; biodefense
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibodies are remarkable in their ability to inactivate even the most potent plant and microbial toxins, including botulinum, tetanus, diphtheria, anthrax and ricin toxins. While this fact has been recognized for more than a century, surprisingly little is known about the molecular mechanisms by which antibodies actually neutralize toxins. Indeed, historically, there has been little incentive to investigate the nature of toxin-antibody interactions because of the success of so many toxin vaccines and therapies. However, this has changed in the past decade with the global demand in the public health and biodefense sectors for new generation antibody-based countermeasures that are safer and more effective. With the surge in new research, it is now becoming increasingly apparent that the interactions between toxins-antibodies are as complex, sophisticated and interesting as the toxins themselves.
The goal of this special issue of Toxins is to provide a state-of-the-art look into the diverse mechanisms by which antibodies neutralize toxins and insights into how understanding these interactions will have applications for next generation vaccines and therapeutics.
Dr. Nicholas J. Mantis
Guest Editor
Manuscript Submission Information
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Keywords
- antibody
- neutralization
- protection
- clearance
- vaccine
- therapeutics
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