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Special Issue "From Toxins to Drugs"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (30 June 2019).
Laboratory of Neuropharmacology, Neuro-oncology and Neural Engineering, School of Pharmacy-Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
Interests: animal venoms, neurotoxins, nerve growth factors, disintegrins, neurotoxicity and neuroprotection, neurodegenerative diseases, neuropharmacology and neurooncology, preclinical pharmacological assessments, in vitro and in vivo model systems, drug development
Toxins represent a wide range of biologically active chemical structures including protein and peptide toxins that target with high selectivity and efficacy a variety of membrane receptors, ion channels, enzymes and intracellular signaling molecules. Toxins can therefore be seen as large natural libraries of potential new drugs that are continuously selected and highly refined by the evolution process, up to the point where every molecule is endowed with the optimal pharmacological properties. Toxins therefore, are unique pharmacological tools to investigate cellular and systems physiology and are highly valuable in the context of drug discovery and development as well as in therapy of different diseases. Nevertheless the use of venoms and derived toxins for drug discovery is a rapidly emerging but still mostly unrealized prospective, due to several major difficulties such as availability, the chemical complexity of venoms and the tedious and expensive process of drug development. The biopharmaceutical industry is in dire need of innovation since intense progress in the identification of “druggable” targets at the molecular level has not necessarily resulted in the identification of novel drugs. Successes in bringing to market therapeutic monoclonal antibodies, recombinant proteins and synthetic peptides have increased the attractiveness of “biologics” as novel drugs, with several hundred antibodies and peptides in the clinic and many others under clinical evaluation. Therefore, proteins and peptide toxins from animal venoms are representing a novel class of biologics. They are very potent, highly target-specific but have much lower immunogenicity than antibodies and show much higher resistance to degradation than linear peptides. Drugs from toxins are few, but those developed contributed significantly to therapy of pain, cancer, blood pressure and hemostasis control. These aspects will be emphasized in this Special Issue by selected toxins. Through the combination of venomics, transcriptomics, proteomics, recombinant proteins molecular pharming, combinatorial peptide synthesis and development of targeted micro and nano carrier delivery systems, the contribution of toxins to the future drug development seems to be very promising.
Prof. Philip Lazarovici
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Lead compound
- Therapeutic applications
- C- type lectin related proteins
- Antiplatelets and analgesic drugs