Special Issue "Immunotoxins—A Special Issue Devoted to Combination Approaches for Cancer Treatment"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (15 December 2017) | Viewed by 5735
Interests: antibodies; toxins; cancer therapeutics; cell biology; immunotoxins
Special Issues, Collections and Topics in MDPI journals
Antibody-toxin or ligand-toxin proteins (here generically called ‘immunotoxins’) have been used extensively to bind and kill cancer cells. In this regard, these cytotoxic chimeric proteins are targeted to particular surface proteins and thereby gain entry to the cell interior where they shut down the host cell protein synthetic machinery. In rare instances, this simple strategy has led to complete clinical remissions benefitting a small number of cancer patients. However, more often than not, the injection of an immunotoxin produces only a partial response indicating that additional agents are needed to enhance antitumor activity. To highlight one avenue of improvement, the next Special Issue on Immunotoxins will focus on combination therapies where the immunotoxin ‘platform’ is joined with other agents with the goal of achieving better outcomes. Combination treatments can be developed in tissue culture systems, immunological models, tumor models or as part of a clinical trial. With the advent of large drug libraries, immunotherapy, checkpoint inhibitors and vaccines, combination strategies can follow a number of highly interesting directions.
Dr. David J. Fitzgerald
Manuscript Submission Information
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