Mycotoxin Contamination in Animal Nutrition and Its Mitigation Strategies

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 599

Special Issue Editors


E-Mail Website
Guest Editor
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Interests: mycotoxin; animal nutrition; immunology; tight junction; rotavirus; intestinal organoid

E-Mail Website
Guest Editor
United Animal Health, Sheridan, IN 46069, USA
Interests: mycotoxin; animal nutrition; gut microbiome; immunity and cell culture

Special Issue Information

Dear Colleagues,

The presence of trichothecene mycotoxins in feed and food has emerged as a major threat to both animal and human health, as up to 25% of cereal production across the globe could be contaminated with these mycotoxins. The intestine has been shown to be the first physical barrier against external food contaminants and the major target organ for these mycotoxins. Regardless of the way of exposure, mycotoxin can be rapidly absorbed and then widely distributed after oral consumption. The presence of mycotoxins in cereal products and byproducts has been shown to induce different toxic effects on mammals, including feed refusal, vomiting, salivation, and weight loss. Thus, the understanding of the absorption, distribution, metabolism, and excretion of mycotoxin is critical for risk assessments and the development of mitigation strategies. In addition, mycotoxin-induced gut damage in animals has a negative consequence on the health status of animals that could be easily exacerbated by other stressors, such as pathogens and endotoxins. Recently, a growing number of physical, chemical, and nutritional detoxification methods have been developed to control mycotoxin contamination. Therefore, this Special Issue aims to summarize recent advances in mycotoxin’s impact on animal health, as well as strategies for mitigation.

Dr. Enkai Li
Dr. Hang Lu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mycotoxin
  • gut health
  • mitigation
  • environment
  • growth performance
  • immunology
  • toxicology
  • microbiota

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 6584 KiB  
Article
Protective Effect of Lipoic Acid on Oxidative Stress and Tissue Damage Induced by Aflatoxin B1 in Young Laying Hens
by Yihong Chu, Huanbin Wang, Xinyu Xu, Yun Ji, Yiting Zhao, Qianqian Yu, Shahid Ali Rajput, Yi Xue and Desheng Qi
Toxins 2025, 17(4), 184; https://doi.org/10.3390/toxins17040184 - 6 Apr 2025
Viewed by 389
Abstract
The aim of this study is to investigate the alleviating effect of lipoic acid on oxidative stress and tissue damage induced by aflatoxin B1 (AFB1) in young laying hens. The experiment was divided into a control group, an AFB1 [...] Read more.
The aim of this study is to investigate the alleviating effect of lipoic acid on oxidative stress and tissue damage induced by aflatoxin B1 (AFB1) in young laying hens. The experiment was divided into a control group, an AFB1 group, and three lipoic acid treatment groups. The AFB1 group and three lipoic acid treatment groups were given diets supplemented with 90 μg/kg of AFB1. The additional amounts of lipoic acid were 20, 100, and 500 mg/kg, respectively, with a feeding period of 4 weeks. The experimental results showed that AFB1 significantly increased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and malondialdehyde (MDA) in the serum and significantly decreased the levels of total protein (TP), albumin (ALB), total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) (p < 0.05). In addition, AFB1 damaged the structure of the liver, spleen, and ovarian tissues. Lipoic acid reduced the levels of ALT, AST, ALP, and MDA in the serum and increased the levels of TP, ALB, T-SOD, GSH-Px, and CAT (p < 0.05). Meanwhile, lipoic acid also protected mitochondrial structure and alleviated liver, spleen, and ovarian tissue damage caused by AFB1. In summary, lipoic acid can alleviate oxidative stress and tissue damage caused by AFB1 in young laying hens. Full article
Show Figures

Figure 1

Back to TopTop