Symmetry in Biomolecules or Related Chiral Molecules

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Chemistry: Symmetry/Asymmetry".

Deadline for manuscript submissions: closed (1 August 2020) | Viewed by 10877

Special Issue Editor

Special Issue Information

Dear Colleagues,

Biomolecules such as proteins and DNA usually have asymmetric stereochemistry, namely chirality, and their related (chiral) molecules also have similar symmetric structures, properties, and functions, enabling appropriate molecular recognition through proper fit. For example, the stereochemistry as well as asymmetry (in the context of chirality) of chiral metal complexes—which are sometimes used as asymmetric catalysts for organic synthesis—has helped to establish these compounds as well as this research field in chemistry and biochemistry. In addition to solely molecular stereochemistry, crystal structures of chemical compounds or proteins, including supramolecular structures, or (chroptical) spectroscopic data including electronic states and theoretical or computational interpretation, are important tools for studying these materials. This Special Issue of Symmetry, “Symmetry in Biomolecules or Related Chiral Molecules”, will feature articles that deal with broad topics in biochemical and/or chemical chiral molecules.

Prof. Dr. Takashiro Akitus
Guest Editor

Manuscript Submission Information

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Published Papers (3 papers)

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Research

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14 pages, 5025 KiB  
Article
Electron Transfer via Helical Oligopeptide to Laccase Including Chiral Schiff Base Copper Mediators
by Kumpei Kashiwagi, Francesco Tassinari, Tomoyuki Haraguchi, Koyel Banerjee-Gosh, Takashiro Akitsu and Ron Naaman
Symmetry 2020, 12(5), 808; https://doi.org/10.3390/sym12050808 - 12 May 2020
Cited by 9 | Viewed by 2749
Abstract
The oxygen reduction efficiency of a laccase-modified electrode was found to depend on the chirality of the oligopeptide linker used to bind the enzyme to the surface. At the same time, the electron transfer between the cathode electrode and the enzyme is improved [...] Read more.
The oxygen reduction efficiency of a laccase-modified electrode was found to depend on the chirality of the oligopeptide linker used to bind the enzyme to the surface. At the same time, the electron transfer between the cathode electrode and the enzyme is improved by using a copper(II) complex with amino-acid derivative Schiff base ligand with/without azobenzene moiety as a mediator. The increased electrochemical current under both O2 and N2 proves that both the mediators are active towards the enzyme. Full article
(This article belongs to the Special Issue Symmetry in Biomolecules or Related Chiral Molecules)
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17 pages, 5403 KiB  
Article
Photo-Tunable Azobenzene-Anthraquinone Schiff Base Copper Complexes as Mediators for Laccase in Biofuel Cell Cathode
by Kazuto Kajiwara, Sayantan Pradhan, Tomoyuki Haraguchi, Chittaranjan Sinha, Rakesh Parida, Santanab Giri, Gourisankar Roymahaptra and Takashiro Akitsu
Symmetry 2020, 12(5), 797; https://doi.org/10.3390/sym12050797 - 11 May 2020
Cited by 7 | Viewed by 3053
Abstract
Induced chirality (achiral target in chiral matrix such as proteins) sometimes play a useful role in evaluating supramolecular systems involving biomolecules. Enzymatic fuel cells, which generate electricity via enzymatic redox reactions at electrodes hold a significant potential for sustainable power. Bacterial laccase, a [...] Read more.
Induced chirality (achiral target in chiral matrix such as proteins) sometimes play a useful role in evaluating supramolecular systems involving biomolecules. Enzymatic fuel cells, which generate electricity via enzymatic redox reactions at electrodes hold a significant potential for sustainable power. Bacterial laccase, a multi-copper oxidase, was used in the cathodic compartment of the enzymatic biofuel cells because of its low redox potential. Three new salen Cu(II) complexes were designed and investigated as mediators. The Schiff base ligands consisted of both a redox-active (anthraquinone) and a photochromic (azobenzene) moiety. The interaction between laccase and a mediator was examined with induced circular dichroism (CD) and the docking tool to observe in which of the laccase domains the mediators bind as well as study the photo-induced tuning of both the cis-trans photoisomerization and orientation by the Weigert effect. Both the electrochemical and photochromic properties are also discussed and compared using density functional theory (DFT), time-dependent (TD)-DFT, and docking simulations. Full article
(This article belongs to the Special Issue Symmetry in Biomolecules or Related Chiral Molecules)
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Review

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39 pages, 20730 KiB  
Review
Possible Physical Basis of Mirror Symmetry Effect in Racemic Mixtures of Enantiomers: From Wallach’s Rule, Nonlinear Effects, B–Z DNA Transition, and Similar Phenomena to Mirror Symmetry Effects of Chiral Objects
by Valerii A. Pavlov, Yaroslav V. Shushenachev and Sergey G. Zlotin
Symmetry 2020, 12(6), 889; https://doi.org/10.3390/sym12060889 - 31 May 2020
Cited by 4 | Viewed by 3944
Abstract
Effects associated with mirror symmetry may be underlying for a number of phenomena in chemistry and physics. Increase in the density and melting point of the 50%L/50%D collection of enantiomers of a different sign (Wallach’s rule) is probably based on a physical effect [...] Read more.
Effects associated with mirror symmetry may be underlying for a number of phenomena in chemistry and physics. Increase in the density and melting point of the 50%L/50%D collection of enantiomers of a different sign (Wallach’s rule) is probably based on a physical effect of the mirror image. The catalytic activity of metal complexes with racemic ligands differs from the corresponding complexes with enantiomers as well (nonlinear effect). A similar difference in the physical properties of enantiomers and racemate underlies L/D inversion points of linear helical macromolecules, helical nanocrystals of magnetite and boron nitride etc., B–Z DNA transition and phenomenon of mirror neurons may have a similar nature. Here we propose an explanation of the Wallach effect along with some similar chemical, physical, and biological phenomena related to mirror image. Full article
(This article belongs to the Special Issue Symmetry in Biomolecules or Related Chiral Molecules)
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