Asymmetry Synthesis: Topics, Advances and Applications

Dear Colleagues,

As Morrison and Mosher put it, ‘asymmetric synthesis’ is the transformation of an achiral unit present in a group of substrate molecules into a chiral unit in a way that yields asymmetric amounts of stereoisomers. Therefore, any synthetic procedure wherein one or more additional chiral components are introduced during a functional group transition is considered to be an example of asymmetric synthesis, wherein the reactions employed are highly enantiospecific. Single enantiomer synthesis of chiral compounds is crucial because biological systems, where such type of compounds are utilized, are themselves chiral. Distinct enantiomers have been shown to have notably varied interactions with their respective target biological receptors, and consequently, to elicit a wide range of different effects. The necessity for enantiomerically pure pharmaceuticals and agricultural chemicals is supported by arguments from economics, ecology, and pharmacodynamics, thereby making asymmetric synthesis an area of intense study in both academic and industrial facilities around the world. For instance, the embracement of asymmetric ‘click’ for the synthesis of chiral drug-like molecules with potent biological activity has progressively increased in recent years.

This Special Issue will be focused on the comprehensive idea of ‘asymmetric synthesis’, with in-depth discussion related to the latest approaches made in the field that have been extensively searched for applications in modern day research areas, including but not limited to pharmaceuticals, natural product chemistry, nanomaterials, etc.

Dr. Jandeep Singh
Dr. Manisha Singh
Guest Editors

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