Vibrational Spectroscopy in Radiobiology

A special issue of Radiation (ISSN 2673-592X).

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 3689

Special Issue Editors


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Dipartimento di Medicina Sperimentale, Università della Campania “Luigi Vanvitelli”, 80138 Napoli, Italy
Interests: fluorescence optical methods; vibrational spectroscopies; enzymatic optical biosensing; two-photon microscopy; optical properties of turbid media; biophotonics medical applications.
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Dipartimento di Scienze Ecologiche e Biologiche, Università degli Studi della Tuscia, I-01100 Viterbo, Italy
Interests: optical spectroscopy and microscopy; Raman and SERS techniques; light scattering methods; optical biosensing; optical sensing approaches; diagnosis and disease follow-up and study of ionizing radiation on biosystems
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Dipartimento di Scienze Ecologiche e Biologiche, Università della Tuscia, 01100 Viterb, Italy
Interests: cell culture methods; genotoxicity assays; cell death and proliferation; radiobiology; DNA damage response
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Special Issue Information

Dear Colleagues,

Radiation therapy represents a fundamental tool in cancer treatment. Cancer resilience and (hyper)sensitivity of normal tissue to ionizing radiation can cause control failure and complicate personalized dose prescriptions. Improvements in RT strategies can be attained by considering the substantial differences in radiosensitivity shown by tumor and healthy cells among patients. The ability to customize therapies requires fast and precise predictions of the cellular radioresponse. For this purpose, extensive efforts are continuously being made, but none of the examined predictive assays have been found to be suitable for routine clinical implementation. In addition, many biochemical assays adopted for detecting radiation’s effects on cellular components can induce changes in the biological samples, altering their structure due to the required chemical substances and elaborated preparation procedures. Therefore, the use of new, non-invasive, and fast optical methods able to examine radiation response in vitro or in vivo across a wide variety of samples, even giving information at the level of biomolecules, can represent an extremely useful tool. Vibrational techniques such as Raman and Fourier transform infrared spectroscopy can rapidly and non-invasively investigate biochemical components of cells and tissues with minimal sample preparation. These techniques can allow the analysis of complex biological processes, such as proliferation and cell death processes, attracting a growing interest in the field of radiation-induced cyto- and genotoxicity.

Dr. Maria Lepore
Dr. Ines Delfino
Dr. Roberta Meschini
Guest Editors

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Keywords

  • FT-IR and O-PTIR spectroscopy
  • Raman spectroscopy
  • SERS
  • TERS
  • ionizing radiation
  • vibrational imaging
  • vibrational histopathology
  • cell death and proliferation
  • cyto- and genotoxicity

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Published Papers (2 papers)

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Review

20 pages, 4837 KiB  
Review
Effects Induced in Human Cells and Tissues by Low Doses of Ionizing Radiation: A Review of Vibrational Spectroscopy Contributions
by Ines Delfino, Maria Daniela Falco, Maria Lepore and M. Portaccio
Radiation 2025, 5(2), 10; https://doi.org/10.3390/radiation5020010 - 31 Mar 2025
Viewed by 302
Abstract
Humans are constantly exposed to low doses and low-dose rates of ionizing radiation from both natural and man-made sources. For this reason, there is a growing interest in studies on the biological effects of low-dose radiation. Vibrational spectroscopies, such as Fourier transform infrared [...] Read more.
Humans are constantly exposed to low doses and low-dose rates of ionizing radiation from both natural and man-made sources. For this reason, there is a growing interest in studies on the biological effects of low-dose radiation. Vibrational spectroscopies, such as Fourier transform infrared and Raman micro-spectroscopies, have been fruitfully employed for studying the effects of high doses of ionizing radiation on biosystems. Aiming at clarifying the potential of the above-mentioned spectroscopic techniques to monitor the changes induced in cells, tissues, and other biological samples by low doses of ionizing radiations, we report a review of the literature in this research field. The analysis of published results suggests that vibrational spectroscopies make a valuable contribution. Additional and more systematic investigations could help to fully exploit the capabilities of these spectroscopic techniques. Full article
(This article belongs to the Special Issue Vibrational Spectroscopy in Radiobiology)
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33 pages, 4196 KiB  
Review
Radiobiological Applications of Vibrational Spectroscopy: A Review of Analyses of Ionising Radiation Effects in Biology and Medicine
by Jade F. Monaghan, Hugh J. Byrne, Fiona M. Lyng and Aidan D. Meade
Radiation 2024, 4(3), 276-308; https://doi.org/10.3390/radiation4030022 - 16 Sep 2024
Cited by 3 | Viewed by 2504
Abstract
Vibrational spectroscopic techniques, such as Fourier transform infrared (FTIR) absorption and Raman spectroscopy (RS), offer unique and detailed biochemical fingerprints by detecting specific molecular vibrations within samples. These techniques provide profound insights into the molecular alterations induced by ionising radiation, which are both [...] Read more.
Vibrational spectroscopic techniques, such as Fourier transform infrared (FTIR) absorption and Raman spectroscopy (RS), offer unique and detailed biochemical fingerprints by detecting specific molecular vibrations within samples. These techniques provide profound insights into the molecular alterations induced by ionising radiation, which are both complex and multifaceted. This paper reviews the application of rapid and label-free vibrational spectroscopic methods for assessing biological radiation responses. These assessments span from early compartmentalised models such as DNA, lipid membranes, and vesicles to comprehensive evaluations in various living biological models, including tissues, cells, and organisms of diverse origins. The review also discusses future perspectives, highlighting how the field is overcoming methodological limitations. RS and FTIR have demonstrated significant potential in detecting radiation-induced biomolecular alternations, which may facilitate the identification of radiation exposure spectral biomarkers/profiles. Full article
(This article belongs to the Special Issue Vibrational Spectroscopy in Radiobiology)
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