Special Issue "Modeling and Analysis of Signal Transduction Networks"
Deadline for manuscript submissions: closed (31 July 2014)
A printed edition of this Special Issue is available here.
Prof. Dr. Juergen Hahn
Department of Biomedical Engineering, Department of Chemical & Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
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Phone: +1 518 276 2138
Fax: +1 518 276 3035
Interests: systems biology; parameter estimation; experimental design; modeling
Signal transduction pathways play a key role in systems biology. These pathways are responsible for relaying cellular information and are also involved in regulating cellular responses. An understanding of signal transduction mechanisms may enable the improvement of treatment options for diseases that are affected by signal transduction mechanisms. One approach for elucidating the dynamics of signal transduction pathways is the derivation of models describing said pathways. However, deriving an accurate signal transduction pathway is difficult. The mechanisms tend to involve many components and there is cross-talk among different pathways. Also, measurements of signal transduction pathway components tend to be sparse and noisy such that the system will have a large degree of uncertainty with respect to both its structure and parameter values. Consequently, validating and refining signal transduction pathway models is crucial.
This Special Issue solicits contributions concerning the modeling and analysis of signal transduction pathways. Contributions involving the modeling and simulation of pathways are of interest. Also welcome are papers concerning methodologies used for modeling and analyzing pathways (e.g., sensitivity analysis, experimental design, parameter estimation, inverse problems or experimental techniques).
Professor Juergen Hahn
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1100 CHF (Swiss Francs). Please note that for papers submitted after 30 June 2019 an APC of 1200 CHF applies. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- signal transduction
- sensitivity analysis
- parameter estimation
- experimental design