Personalized Medicine for Autism Spectrum Disorder

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 25 May 2025 | Viewed by 8920

Special Issue Editor


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Guest Editor
1. Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
2. Department of Chemical & Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
3. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
Interests: systems biology; machine learning; signaling and metabolic pathways; autism spectrum disorder
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Special Issue Information

Dear Colleagues,

Autism spectrum disorder presents in a highly heterogeneous manner. This includes but is not limited to co-occurring conditions that most individuals with autism are diagnosed with. Given this large variability in how autism presents, approaches that are tailored towards individuals are essential.

This Special Issue seeks contributions that focus on approaches for diagnosis, classification, treatment, or management of individuals with autism spectrum disorder. Papers involving clinical trials are welcome as are computational/theoretical studies which are based upon real data. Of special interest are contributions which specifically address challenges related to the heterogeneity that exist in ASD as well as the effect of environmental factors on ASD.

Prof. Dr. Juergen Hahn
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autism spectrum disorder
  • comorbidity
  • personalized medicine
  • environmental factors
  • diagnosis
  • classification
  • treatment
  • management

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Published Papers (1 paper)

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Research

10 pages, 1721 KiB  
Article
Aggressive and Autoaggressive Behaviors in Patients with Autism Spectrum Disorder in Correlation with Middle Cerebral Artery Flow Velocity
by Maciej Abakumow, Maciej Przybylski, Mariusz Słoma, Olga Markowska, Katarzyna Sowa, Przemysław Jaśkiewicz and Krzysztof Kowalczuk
J. Pers. Med. 2024, 14(9), 1010; https://doi.org/10.3390/jpm14091010 - 22 Sep 2024
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Abstract
Background/Objectives The purpose of this study was to see whether there is a correlation between the behavior of autism spectrum disorder patients and brain abnormalities based on the velocity of blood flow in the MCA (middle cerebral artery). Methods: The use [...] Read more.
Background/Objectives The purpose of this study was to see whether there is a correlation between the behavior of autism spectrum disorder patients and brain abnormalities based on the velocity of blood flow in the MCA (middle cerebral artery). Methods: The use of HAP (High Altitude Protection) suits, which are used in aviation, to treat patients with ASD (autism spectrum disorder) causes significant changes in their functioning and physiological processes. These changes are not only noted in psychological tests but are observed in cerebral blood flow using transcranial Doppler ultrasound of the MCA. Results The results of this study made it possible to distinguish two groups with different flow velocities, which can be characterized as flows of less than 80 cm/s and flows of more than 80 cm/s. In addition, it was shown that in patients with elevated blood flow velocity, aggressive behaviors account for 86.96%, while self-aggressive behaviors account for 65.2%. On the other hand, in the case of patients with reduced flow velocity, i.e., less than 80 cm/s, the rate of aggressive behavior is 20% and that of self-aggressive behavior is 50%. The experiment showed that after therapy, there is a normalization of blood flow, which increased in the case of patients with a reduced flow rate below 80 cm/s and, in the case of elevated blood velocity after therapy, decreased towards normal levels. Conclusions The observed rate of normalization of flow velocities in the MCA translated into significant changes in the behavior and functioning of patients in the neurotypical direction, which was noticeable in the psychological tests conducted. Full article
(This article belongs to the Special Issue Personalized Medicine for Autism Spectrum Disorder)
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