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Open AccessArticle

Mathematical Modeling and Analysis of Crosstalk between MAPK Pathway and Smad-Dependent TGF-β Signal Transduction

by Ji Liu 1,2, Wei Dai 2,3 and Juergen Hahn 2,3,*
1
Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
2
Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
3
Department of Biomedical Engineering and Department of Chemical & Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
*
Author to whom correspondence should be addressed.
Processes 2014, 2(3), 570-595; https://doi.org/10.3390/pr2030570
Received: 6 June 2014 / Revised: 15 July 2014 / Accepted: 21 July 2014 / Published: 4 August 2014
(This article belongs to the Special Issue Modeling and Analysis of Signal Transduction Networks)
Broad evidence exists for cross talk between the Mitogen-activated protein kinases (MAPK) pathway and Smad-dependent TGF-β signal transduction. A variety of studies, oftentimes involving different cell types, have identified several potential mechanisms for the crosstalk. However, there is no clear consensus on the actual mechanism(s) responsible for the crosstalk. This work develops a model of the pathway, including several hypothesized crosstalk mechanisms, and discusses which of the potential mechanisms can appropriately describe observed behaviors. Simulation results show a good agreement of the findings with results reported in the literature. View Full-Text
Keywords: crosstalk; MAPK pathway; Smad-dependent TGF-β signal transduction; model of the pathway crosstalk; MAPK pathway; Smad-dependent TGF-β signal transduction; model of the pathway
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Liu, J.; Dai, W.; Hahn, J. Mathematical Modeling and Analysis of Crosstalk between MAPK Pathway and Smad-Dependent TGF-β Signal Transduction. Processes 2014, 2, 570-595.

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