Methods for Modeling and Computation in Cell Bioengineering

Dear Colleagues,

Advancement in modeling biomechanical and biochemical processes plays a significant role in cellular biology. Novel modeling and computational approaches in microanalysis allow for detailed and precision description of subcellular structures, mechanics, biochemical processes, signaling, and interactions of individual cells with other systems. Recently, there has been a number of works showing that human whole-cell models are becoming feasible. Such models will allow us to deeply understand cell biology and thus help in medical research and clinical practice. Novel results and findings are also available through innovative approaches, workflows, and algorithms to collect and analyze large, multiscale, and multidimensional datasets representing structures and processes in cells.

This Special Issue on “Methods for Modeling and Computation in Cell Bioengineering” seeks high-quality work focusing on the latest approaches, methods, and algorithms for dynamic models to trace the temporal behavior of the cellular system and its variables, modeling and analysis of signal transduction networks, stochastic description of cells at the molecular level, cell–cell and cell–extracellular matrix biochemical and physical interactions, novel computational approaches and workflows for analysis of existing large datasets, such as fluorescence microscope image databases, protein atlases, dynamic proteomics databases, or synthetic datasets, and related topics. We also welcome discussion on nonconventional approaches that offer unique data in cell biology through new technology and mathematical/computational modeling. Topics include but are not limited to:

• Data mining schemes and processing workflows for cell microanalysis using multidimensional datasets;
• Machine learning for the processing of multidimensional and multiscale datasets to study dynamics of cell processes;
• Computational modeling surface, structures and functional subtleties of cells;
• Modeling cellular stiffness, mechanics and the cytoskeletal components and factors that regulate them;
• Cell-based computational models to simulate interactions of individual cells in virtual tissues;
• Advances in cellular microanalysis that improve rapid and accurate detection and treatment of diseases.

Prof. Dr. Ivo Provazník
Dr. Vratislav Čmiel
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.