Study on Metabolic Mechanism of Chronic Diseases
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 17919

Special Issue Editors
Interests: the main research interests of Dr Claudio Pirozzi lie in the pharmacological control of metabolic disorders, including obesity, nonalcoholic fatty liver disease (NAFLD), and metabolic syndrome
Interests: mood disorders; obesity; neuroendocrinology; neuroinflammation; gut-brain axis
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Special Issue Information
Dear Colleagues,
Recently, many clinical studies have been performed to develop new therapeutic strategies for the treatment of metabolic disorders, including obesity, insulin resistance, diabetes, metabolic syndrome. Metabolic alterations related to incorrect dietary habits including fat overnutrition have become common, threatening public health, markedly enhancing the onset and the progression of metabolic diseases and associated immunological and inflammatory complications. However, many researchers have mainly focused on functional studies which attempt to discover metabolic mechanisms of these chronic pathologies.
This Special Issue welcomes papers on research characterized by in vitro and in vivo approaches aimed at identifying specific molecular mechanisms in controlling metabolic diseases caused by lipid overload or high-fat diets in addition to counteracting the associated disorders involving the induction of inflammatory process and immune response.
We welcome papers on the following topics:
- Study of metabolic mechanisms underlying chronic diseases
- Discovery of prophylactic and/or therapeutic approaches for the treatment of chronic diseases
- In vitro/in vivo models of fat overnutrition and/or lipid overload which mimic the alterations characterizing metabolic disorders, such as obesity and/or diabetes
- Metabolic analysis of various factors in vivo in animal disease models (chronic metabolic diseases, including obesity, diabetes, and insulin and/or leptin resistance)
- Immune-metabolic dysfunction induced by chronic diseases
- Low-grade inflammation and/or oxidative/mitochondrial damage associated with metabolic pathologies and their mechanisms
- Study of the gut–brain axis and its involvement in mental disorders
- The connection between metainflammation and neuroinflammation
- The influence of metabolic alterations in worsening neuropsychiatric disorders
Dr. Claudio Pirozzi
Dr. Adriano Lama
Guest Editors
Manuscript Submission Information
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Keywords
- Chronic metabolic disorders
- In vitro and in vivo mechanistic studies of metabolic diseases
- Fat overnutrition or high-fat diets
- Cell lipid overload which resembles the metabolic alterations characterizing obesity and insulin and leptin resistance
- Understanding immunological involvement through cells and animal models
- Metainflammation
- Oxidative/mitochondrial damage as mechanisms of metabolic pathologies
- Interconnection between metabolic alterations and mental disorders
- Gut–brain axis
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