Study on Metabolic Mechanism of Chronic Diseases

Dear Colleagues,

Recently, many clinical studies have been performed to develop new therapeutic strategies for the treatment of metabolic disorders, including obesity, insulin resistance, diabetes, metabolic syndrome. Metabolic alterations related to incorrect dietary habits including fat overnutrition have become common, threatening public health, markedly enhancing the onset and the progression of metabolic diseases and associated immunological and inflammatory complications. However, many researchers have mainly focused on functional studies which attempt to discover metabolic mechanisms of these chronic pathologies.

This Special Issue welcomes papers on research characterized by in vitro and in vivo approaches aimed at identifying specific molecular mechanisms in controlling metabolic diseases caused by lipid overload or high-fat diets in addition to counteracting the associated disorders involving the induction of inflammatory process and immune response.

We welcome papers on the following topics:

1. Study of metabolic mechanisms underlying chronic diseases
2. Discovery of prophylactic and/or therapeutic approaches for the treatment of chronic diseases
3. In vitro/in vivo models of fat overnutrition and/or lipid overload which mimic the alterations characterizing metabolic disorders, such as obesity and/or diabetes
4. Metabolic analysis of various factors in vivo in animal disease models (chronic metabolic diseases, including obesity, diabetes, and insulin and/or leptin resistance)
5. Immune-metabolic dysfunction induced by chronic diseases
6. Low-grade inflammation and/or oxidative/mitochondrial damage associated with metabolic pathologies and their mechanisms
7. Study of the gut–brain axis and its involvement in mental disorders
8. The connection between metainflammation and neuroinflammation
9. The influence of metabolic alterations in worsening neuropsychiatric disorders

Dr. Claudio Pirozzi
Dr. Adriano Lama
Guest Editors

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