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Molecularly Imprinted Polymers: Towards More Selective Electrochemical Detection

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2777

Special Issue Editor


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Guest Editor
Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt
Interests: pharmaceutical analysis; molecularly imprinted polymers; flow injection analysis; computer assis

Special Issue Information

Dear Colleagues,

During the past decades, molecularly imprinted polymers (MIPs) have been shown to be an excellent class of modifiers for the design of electrochemical sensors. The Polymers offer the advantage of being easy to design, low cost and have possibility to be designed for different classes of micro and macro molecules. The polymers can be prepared through different approaches that can be chemical or electrochemical depending on the nature of the target template and its physicochemical properties. That is why they were successfully applied for the detection of many classes of analytes including pathogens, heavy metals, wastewater contaminants and pharmaceutical compounds. The current issue aims at shedding light on more recent applications of different classes of electrochemical sensors involving MIPs.

Prof. Dr. Rasha Mohamed El Nashar
Guest Editor

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Keywords

  • molecularly imprinted polymers
  • modified sensors
  • pharmaceutical compounds
  • pathogens
  • heavy metals
  • pesticides
  • organic contaminants
  • point of care

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Published Papers (1 paper)

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Research

14 pages, 2697 KiB  
Article
New Potentiometric Screen-Printed Platforms Modified with Reduced Graphene Oxide and Based on Man-Made Imprinted Receptors for Caffeine Assessment
by Hisham S. M. Abd-Rabboh, Abdel El-Galil E. Amr, Abdulrahman A. Almehizia, Ahmed M. Naglah and Ayman H. Kamel
Polymers 2022, 14(10), 1942; https://doi.org/10.3390/polym14101942 - 10 May 2022
Cited by 6 | Viewed by 2269
Abstract
Caffeine is a psychoactive drug that is administered as a class II psychotropic substance. It is also considered a component of analgesics and cold medicines. Excessive intake of caffeine may lead to severe health damage or drug addiction problems. The assessment of normal [...] Read more.
Caffeine is a psychoactive drug that is administered as a class II psychotropic substance. It is also considered a component of analgesics and cold medicines. Excessive intake of caffeine may lead to severe health damage or drug addiction problems. The assessment of normal caffeine consumption from abusive use is not conclusive, and the cut-off value for biological samples has not been established. Herein, new cost-effective and robust all-solid-state platforms based on potentiometric transduction were fabricated and successfully utilized for caffeine assessment. The platforms were modified with reduced graphene oxide (rGO). Tailored caffeine-imprinted polymeric beads (MIPs) based on methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) were prepared, characterized, and used as recognition receptors in the presented potentiometric sensing devices. In 50 mM MES buffer, the sensors exhibited a slope response of 51.2 ± 0.9 mV/decade (n = 6, R2 = 0.997) over the linear range of 4.5 × 10−6–1.0 × 10−3 M with a detection limit of 3.0 × 10−6 M. They exhibited fast detection of caffeinium ions with less than 5 s response time (<5 s). The behavior of the presented sensors towards caffeinium ions over many common organic and inorganic cations was evaluated using the modified separate solution method (MSSM). Inter-day and intra-day precision for the presented analytical device was also evaluated. Successful applications of the presented caffeine sensors for caffeine determination in commercial tea and coffee and different pharmaceutical formulations were carried out. The data obtained were compared with those obtained by the standard liquid chromatographic approach. The presented analytical device can be considered an attractive tool for caffeine determination because of its affordability and vast availability, particularly when combined with potentiometric detection. Full article
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