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Polymers
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Biomedical Polymer Materials for Wound Healing
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Biomedical Polymer Materials for Wound Healing

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 9499

Special Issue Editor

Dr. Panpan Pan

E-Mail Website
Guest Editor
Marine College, Shandong University, Weihai 264209, China
Interests: research on marine biomedical materials for tissue repair and regeneration; extraction and high value utilisation of marine shellfish bioactive substances; design, assembly and application of functional porous composite materials

Special Issue Information

Dear Colleagues,

Chronic hard-to-heal wounds, uncontrollable wound ulcers, diabetic foot, and fall fractures due to imbalance of bone homeostasis in aging are major medical and public health problems that require solutions in an aging society. The difficulty lies in the weak active regulatory repair function of aging organisms.

We are pleased to invite you to share your latest research progress, development direction, and advanced reviews of biomedical polymer materials that utilize polymers as the core raw materials in wound healing.

This Special Issue aims to establish an autonomous repair strategy for complex hard-to-heal wounds by discussing and presenting the functionalization and spatiotemporal regulation of tissue regeneration, with a view to breaking through the clinical technical bottleneck of vascularized regenerative repair of hard-to-heal wounds. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: biomedical polymer; wound healing; tissue regeneration; multifunctional hydrogels; tissue-engineered scaffolds, skin dressings; hemostatic materials; wearable devices; and drug-controlled release systems.

I look forward to receiving your contributions.

Dr. Panpan Pan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical polymer
  • wound healing
  • tissue regeneration
  • multifunctional hydrogels
  • tissue-engineered scaffolds
  • skin dressings
  • hemostatic materials
  • wearable devices
  • drug-controlled release systems

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Published Papers (3 papers)

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Research

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11 pages, 3525 KiB  
Article
Wound Healing in Human Skin Equivalents Reconstructed with Biopolymers Under Fine-Dust Exposure
by Taeeun Kim, Junwoo Lim, Jaehyun Jeong and Heewook Ryu
Polymers 2025, 17(7), 901; https://doi.org/10.3390/polym17070901 - 27 Mar 2025
Viewed by 422
Abstract
Airborne fine-dust pollution poses a significant threat to both respiratory and skin health; however, the skin’s wound-healing process in response to such exposure remains underexplored. Therefore, this study examined the effect of fine-dust-model compounds, specifically polycyclic aromatic hydrocarbons (PM10-PAHs) and trace-metal-containing [...] Read more.
Airborne fine-dust pollution poses a significant threat to both respiratory and skin health; however, the skin’s wound-healing process in response to such exposure remains underexplored. Therefore, this study examined the effect of fine-dust-model compounds, specifically polycyclic aromatic hydrocarbons (PM10-PAHs) and trace-metal-containing particles (PM10-Trace), on the wound-healing process using human skin equivalents reconstructed with collagen-based biomaterials and human skin cells. Our findings revealed that fine-dust exposure significantly delayed wound closure by 2–3 times compared with unexposed controls, impairing re-epithelialization. Live imaging of wound-healing dynamics revealed that trace-metal-containing particles had a more pronounced inhibitory effect than polycyclic aromatic hydrocarbons. Furthermore, fine-dust exposure elevated protease-activated receptor-1 (PAR1) expression by up to 161%, indicating significant physiological disruption. Additionally, fine-dust exposure triggered inflammation and oxidative stress, leading to structural and functional damage in the reconstructed skin. These results provide critical insights into how airborne pollutants disrupt skin repair mechanisms and highlight the need for targeted strategies to mitigate their harmful effects. Full article
(This article belongs to the Special Issue Biomedical Polymer Materials for Wound Healing)
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Review

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29 pages, 3571 KiB  
Review
Advances in Smart-Response Hydrogels for Skin Wound Repair
by Yinuo Fan, Han Wang, Chunxiao Wang, Yuanhao Xing, Shuying Liu, Linhan Feng, Xinyu Zhang and Jingdi Chen
Polymers 2024, 16(19), 2818; https://doi.org/10.3390/polym16192818 - 5 Oct 2024
Cited by 8 | Viewed by 3965
Abstract
Hydrogels have emerged as promising candidates for biomedical applications, especially in the treatment of skin wounds, as a result of their unique structural properties, highly tunable physicochemical properties, and excellent biocompatibility. The integration of smart-response features into hydrogels allows for dynamic responses to [...] Read more.
Hydrogels have emerged as promising candidates for biomedical applications, especially in the treatment of skin wounds, as a result of their unique structural properties, highly tunable physicochemical properties, and excellent biocompatibility. The integration of smart-response features into hydrogels allows for dynamic responses to different external or internal stimuli. Therefore, this paper reviews the design of different smart-responsive hydrogels for different microenvironments in the field of skin wound therapy. First, the unique microenvironments of three typical chronic difficult-to-heal wounds and the key mechanisms affecting wound healing therapeutic measures are outlined. Strategies for the construction of internal stimulus-responsive hydrogels (e.g., pH, ROS, enzymes, and glucose) and external stimulus-responsive hydrogels (e.g., temperature, light, electricity, and magnetic fields) are highlighted from the perspective of the wound microenvironment and the in vitro environment, and the constitutive relationships between material design, intelligent response, and wound healing are revealed. Finally, this paper discusses the severe challenges faced by smart-responsive hydrogels during skin wound repair and provides an outlook on the combination of smart-responsive hydrogels and artificial intelligence to give scientific direction for creating and using hydrogel dressings that respond to stimuli in the clinic. Full article
(This article belongs to the Special Issue Biomedical Polymer Materials for Wound Healing)
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30 pages, 15394 KiB  
Review
Principles and Design of Bionic Hydrogel Adhesives for Skin Wound Treatment
by Chunxiao Wang, Xinyu Zhang, Yinuo Fan, Shuhan Yu, Man Liu, Linhan Feng, Qisen Sun and Panpan Pan
Polymers 2024, 16(13), 1937; https://doi.org/10.3390/polym16131937 - 6 Jul 2024
Cited by 5 | Viewed by 4403
Abstract
Over millions of years of evolution, nature has developed a myriad of unique features that have inspired the design of adhesives for wound healing. Bionic hydrogel adhesives, capable of adapting to the dynamic movements of tissues, possess superior biocompatibility and effectively promote the [...] Read more.
Over millions of years of evolution, nature has developed a myriad of unique features that have inspired the design of adhesives for wound healing. Bionic hydrogel adhesives, capable of adapting to the dynamic movements of tissues, possess superior biocompatibility and effectively promote the healing of both external and internal wounds. This paper provides a systematic review of the design and principles of these adhesives, focusing on the treatment of skin wounds, and explores the feasibility of incorporating nature-inspired properties into their design. The adhesion mechanisms of bionic adhesives are analyzed from both chemical and physical perspectives. Materials from natural and synthetic polymers commonly used as adhesives are detailed regarding their biocompatibility and degradability. The multifunctional design elements of hydrogel adhesives for skin trauma treatment, such as self-healing, drug release, responsive design, and optimization of mechanical and physical properties, are further explored. The aim is to overcome the limitations of conventional treatments and offer a safer, more effective solution for the application of bionic wound dressings. Full article
(This article belongs to the Special Issue Biomedical Polymer Materials for Wound Healing)
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