Branched Polymeric Architectures—Synthesis, Functionalization and Application

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 1813

Special Issue Editor


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Guest Editor
Australian Institute for Bioengineering and Nanotechnology & Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia
Interests: organic and polymer chemistry; polymeric nanocarriers; degradable nanomaterials; polymer-protein hybrid conjugates

Special Issue Information

Dear Colleagues,

Branched polymers have shown widespread academic and commercial success in the preparation of films and novel materials, and now are emerging into the biomedical research space as nanocarriers for use in drug delivery and diagnostics. Branched polymers exhibit ideal sizes for delivery in vivo, have well-established chemistries for their synthesis, and offer multiple methods of incorporation for a variety of targeting, therapeutic and diagnostic moieties. By choice of material and functionality, their biostability or biodegradability can be fine-tuned for multi-staged or time-delayed release of therapeutics. With significant advances in nanomedicine development, in particular, the chemistries surrounding biomolecule conjugation and the evolution of imaging techniques, the multimodal capabilities of branched polymers combined with facile and controlled synthetic engineering of branched polymers has resulted in properties that are ideal for their application as nanocarriers. While polymeric nanocarriers offer limitless synthetic opportunities, to address the many biological challenges that are now well-established in nanotherapeutics, new approaches to how branched architectures are designed are required. To that end, we are bringing together a special collection that aims to address the advances that have been made and the key directions that must be considered in the biologically driven nanomaterial design of branched polymeric nanocarriers. We cordially invite you to submit an article towards this central theme in our special collection.

Dr. Craig A. Bell
Guest Editor

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Keywords

  • polymeric nanocarriers
  • branched polymers
  • biopolymers

Published Papers (1 paper)

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Research

25 pages, 7841 KiB  
Article
Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers
by Katia Bacha, Julien Estager, Sylvie Brassart-Pasco, Catherine Chemotti, Antony E. Fernandes, Jean-Pierre Mbakidi, Magali Deleu and Sandrine Bouquillon
Polymers 2022, 14(17), 3513; https://doi.org/10.3390/polym14173513 - 27 Aug 2022
Cited by 1 | Viewed by 1398
Abstract
For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers were fully characterized [...] Read more.
For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers were fully characterized and showed excellent antioxidant properties. Their cytotoxic properties have been also determined in the case of fibroblast dermal cells. Full article
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