Special Issue "Polyphenols in Plants"

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Simon Vlad Luca
E-Mail Website
Guest Editor
TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany
Interests: natural products; medicinal plants; phytochemistry; metabolite profiling; high-resolution mass spectrometry; downstream processing; liquid–liquid chromatography; centrifugal partition chromatography; countercurrent chromatography; anti-inflammatory; anticancer
Dr. Adriana Trifan
E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania
Interests: pharmacognosy; phytochemistry; high-resolution mass spectrometry; gas chromatography; antimicrobials; anticancer; anti-inflammatory
Special Issues and Collections in MDPI journals
Dr. Gokhan Zengin
E-Mail Website
Guest Editor
Department of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey
Interests: characterization of plant extracts; phenolic compounds; antioxidant capacity; enzyme inhibitory mechanisms and assays

Special Issue Information

Dear Colleagues,

Polyphenols are a very large class of specialized metabolites synthesized by plants for protection against bacteria, fungi and insect attacks. To date, more than 8000 naturally occurring phenolic compounds have been reported in plants. Ubiquitously found in foods and herbal medicines, polyphenols possess a plethora of biological effects (antioxidant, cancer chemopreventive, antimicrobial, anti-inflammatory, cardio-vasculo-protective, immunomodulatory, etc.). These potent bioactivities render them interesting alternatives for pharmaceutical and medical applications. Due to their versatile benefits with regard to human health, research studies focusing on plant-derived polyphenols have considerably increased in recent years.

Therefore, this Special Issue welcomes the submission of articles (original research papers, reviews, perspectives, hypotheses, opinions, modeling approaches and methods) that focus on plant polyphenols and their extraction from plant materials, phytochemical analysis of polyphenol-rich plant extracts with the use of advanced chromatographic and spectrometric techniques, isolation and purification of plant polyphenols, polyphenols in the prevention and management of modern diseases, pharmacokinetics, biotransformation and bioactivity of plant polyphenols, bioactivity evaluation of agro-industrial by-products rich in polyphenolics, management of polyphenols in wastes, importance of plant polyphenols in medicine and food, and preclinical and clinical findings on plant polyphenols.

Dr. Simon Luca
Dr. Adriana Trifan
Dr. Gokhan Zengin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polyphenols
  • Extraction of polyphenols
  • Analysis of polyphenols
  • Purification of polyphenols
  • Bioactivity of polyphenols
  • Pharmacokinetics of polyphenols
  • Polyphenols and modern diseases
  • Polyphenols and by-products
  • Waste polyphenols

Published Papers (2 papers)

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Research

Article
Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey
Plants 2021, 10(6), 1176; https://doi.org/10.3390/plants10061176 - 09 Jun 2021
Viewed by 371
Abstract
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. [...] Read more.
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further. Full article
(This article belongs to the Special Issue Polyphenols in Plants)
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Article
LC-MS/MS Profiles and In Vitro Biological Activities of Extracts of an Endemic Species from Turkey: Stachys cretica ssp. anatolica
Plants 2021, 10(6), 1054; https://doi.org/10.3390/plants10061054 - 25 May 2021
Viewed by 477
Abstract
Background: Genus Stachys is one of the largest of the Lamiaceae family, having around 300 different plant species inhabiting areas with temperate and warm climates. The Stachys species in Turkey are represented with 81 taxa; 51 of them being endemic. Plants of [...] Read more.
Background: Genus Stachys is one of the largest of the Lamiaceae family, having around 300 different plant species inhabiting areas with temperate and warm climates. The Stachys species in Turkey are represented with 81 taxa; 51 of them being endemic. Plants of the Stachys genus have been known for their biological activity and their use in ethnomedicine. Methods: The dominant components of S. cretica ssp. anatolica aqueous and methanol extracts were studied with the LC-MS/MS technique. Results: Chlorogenic acid, apigenin-7-glucoside and verbascoside present as the dominant polyphenols found in studied extracts. The prominent biological activity of the studied S. cretica ssp. anatolica methanol and aqueous extracts showed strong antioxidant activity and inhibition of enzymes tyrosinase and α-amylase, involved in skin disorders and diabetes mellitus type II. Conclusions: This study has proven that the aqueous and methanol extracts of S. cretica ssp. anatolica have prominent antioxidant activity, due to a high abundance of polyphenols. The strong antioxidant properties of S. cretica ssp. anatolica extracts show promising application for the pharmaceutical, food, and cosmetics industries. Full article
(This article belongs to the Special Issue Polyphenols in Plants)
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