The Application of Naturally Derived Molecules and Their Synthetic Analogs in Agriculture and the Fight Against Biotic and Abiotic Stresses That Emerged Under Climate Change

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Plant Response to Abiotic Stress and Climate Change".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 766

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Department of Plant Physiology, Institute of Biology, Nowoursynowska 159 St., Bldg. 37, 02-776 Warsaw, Poland
Interests: abscission zone; crops; organ abscission; plant physiology; stress
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Guest Editor
Department of Plant Physiology and Biotechnology, Nicolaus Copernicus University, ul. Lwowska 1, 87-100 Toruń, Poland
Interests: abiotic and biotic stresses; plant hormone homeostasis; plant physiology
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Special Issue Information

Dear Colleagues,

A major challenge in modern ecological agriculture is mitigating the impact of biotic and abiotic stresses caused by climate change on plants. Currently, naturally derived molecules and their synthetic analogs are extensively studied to enhance plant growth parameters. Equally important are their potential applications in crop protection under adverse conditions induced by various stresses. In agriculture, these molecules exhibit diverse biological effects, such as boosting plants’ ability to absorb nutrients, enhancing biomass production, and inhibiting pathogen infection. They can function as natural pesticides and fungicides, offering an environmentally friendly alternative to conventional treatments with chemicals harmful to humans and animals, thereby minimizing ecological impact and promoting biodiversity conservation. Furthermore, these compounds may enhance plant tolerance to various stresses, including drought, salinity, pathogens, and extreme temperatures, by modulating pathways such as phytohormonal or redox-related processes. Synthetic analogs of naturally derived substances are engineered to improve efficacy, stability, and specificity in targeting stress-induced mechanisms, reducing crop losses. Both synthetic analogs and natural products represent promising strategies for crop protection, stress management, and sustainable agriculture.

Dr. Agata Kućko
Dr. Emilia Wilmowicz
Guest Editors

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Keywords

  • bioactive compounds
  • biotic and abiotic stressors
  • crops
  • growth stimulants
  • natural products
  • phytohormones
  • secondary metabolites
  • sustainability
  • yielding

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Published Papers (1 paper)

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Research

20 pages, 2564 KB  
Article
Investigating the Mechanisms Underlying Citral-Induced Oxidative Stress and Its Contribution to Antifungal Efficacy on Magnaporthe oryzae Through a Multi-Omics Approach
by Yonghui Huang, Ruoruo Wang, Yumei Tan, Yongxiang Liu, Xiyi Ren, Congtao Guo, Rongyu Li and Ming Li
Plants 2025, 14(13), 2001; https://doi.org/10.3390/plants14132001 - 30 Jun 2025
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Abstract
Citral, an organic compound found in lemongrass (Cymbopogon citratus) oil and Litsea cubeba essential oil, has been reported to exhibit notable antifungal activity against Magnaporthe oryzae (M. oryzae), the pathogen of rice blast, which causes significant economic losses in [...] Read more.
Citral, an organic compound found in lemongrass (Cymbopogon citratus) oil and Litsea cubeba essential oil, has been reported to exhibit notable antifungal activity against Magnaporthe oryzae (M. oryzae), the pathogen of rice blast, which causes significant economic losses in rice production. However, the role of citral in inducing oxidative stress related to antifungal ability and its underlying regulatory networks in M. oryzae remain unclear. In this study, we investigated the oxidative effects of citral on M. oryzae and conducted transcriptomic and widely targeted metabolomic (WTM) analyses on the mycelia. The results showed that citral induced superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) activities but reduced glutathione S-transferase (GST) activity with 25% maximal effective concentration (EC25) and 75% maximal effective concentration (EC75). Importantly, citral at EC75 reduced the activities of mitochondrial respiratory chain complex I, complex III and ATP content, while increasing the activity of mitochondrial respiratory chain complex II. In addition, citral triggered a burst of reactive oxygen species (ROS) and a loss of mitochondrial membrane potential (MMP) through the observation of fluorescence. Furthermore, RNA-seq analysis and metabolomics analysis identified a total of 466 differentially expression genes (DEGs) and 32 differential metabolites (DAMs) after the mycelia were treated with citral. The following multi-omics analysis revealed that the metabolic pathways centered on AsA, GSH and melatonin were obviously suppressed by citral, indicating a disrupted redox equilibrium in the cell. These findings provide further evidences supporting the antifungal activity of citral and offer new insights into the response of M. oryzae under oxidative stress induced by citral. Full article
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