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Antioxidant Separation and Identification: Emerging Techniques in the Extraction of...
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Antioxidant Separation and Identification: Emerging Techniques in the Extraction of Phytogenic Compounds

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1093

Special Issue Editors

Dr. Felipe de Moura Souza

E-Mail Website
Guest Editor
Instituto Federal de Educação, Ciência e Tecnologia Goiano, Campus Rio Verde, Rio Verde, Brazil
Interests: phytochemicals; green chemistry; essential oils; electrochemistry; electroanalytics
Special Issues, Collections and Topics in MDPI journals
Dr. Antonella Smeriglio

E-Mail Website
Guest Editor
(ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, Italy
Interests: natural compounds; polyphenols; plant extracts; functional foods; nutraceuticals; food supplements; pharmacology; toxicology; pharmacognosy; antioxidant activity; anti-inflammatory activity; cytoprotective activity; wound healing activity; photoprotective activity; pharmacokinetic and pharmacodynamic studies; clinical studies; inflammatory bowel disease; circular economy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, "Antioxidant Separation and Identification: Emerging Techniques in the Extraction of Phytogenic Compounds", aims to explore cutting-edge methods for separating and identifying antioxidant compounds from plant sources, integrating advanced extraction techniques with bioactivity analysis. We invite contributions on innovative approaches, such as ultra-high-performance liquid chromatography (UHPLC), mass spectrometry, or other high-resolution tools, to isolate and characterize bioactive phytogenics with high antioxidant potential. Emphasis will be on sustainable extraction processes, mechanisms of action, and therapeutic applications in areas such as neuroprotection, anti-inflammatory treatments, and dermatology. By compiling forefront research, this issue seeks to provide a comprehensive view of current advancements and future directions in phytochemistry, fostering collaboration among researchers in biology, chemistry, and biotechnology.

Dr. Felipe de Moura Souza
Dr. Antonella Smeriglio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant identification
  • separation techniques
  • phytogenic compounds
  • extraction methods
  • therapeutic applications
  • bioactive analysis

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Published Papers (1 paper)

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Research

16 pages, 347 KB  
Article
Exploring the Potential of Hop (Humulus lupulus) Cone Residue: Chemical Characterization and Evaluation of Bioactivities
by Giulia Boito Reyes, Emylaine Pereira dos Santos, Everton da Silva Santos, Laura Correia Gonçalves, Gabriela Catuzo Canonico Silva, Zilda Cristiani Gazim, Regina Aparecida Correia Gonçalves, Arildo José Braz de Oliveira, José Pinela, Filipa Mandim, Tânia C. S. P. Pires, Lucio Cardozo-Filho, Rúbia Carvalho Gomes Corrêa and José Eduardo Gonçalves
Plants 2026, 15(7), 994; https://doi.org/10.3390/plants15070994 - 24 Mar 2026
Viewed by 833
Abstract
Humulus lupulus L. (hops), belonging to the Cannabaceae family, is grown mainly for brewing, with 98% of global production directed to this sector. Moreover, large volumes of female cone residues are generated as by-products, representing a valuable source of bioactive compounds that can [...] Read more.
Humulus lupulus L. (hops), belonging to the Cannabaceae family, is grown mainly for brewing, with 98% of global production directed to this sector. Moreover, large volumes of female cone residues are generated as by-products, representing a valuable source of bioactive compounds that can be valorized under green chemistry principles. This study aimed to extract bioactive compounds from hop cone residues sourced from craft breweries using ultrasound-assisted (EH-UA) and microwave-assisted (EH-MA) extraction methods. Hydroalcoholic extracts (70%) were analyzed for chemical composition, antioxidant, antimicrobial, antiproliferative, nitric oxide (NO)-production inhibition, and photoprotective activities. GC-MS identified 32 compounds in EH-MA and 30 in EH-UA, including terpenes, sesquiterpenes, oxygenated sesquiterpenes, and fatty acids. Both extracts demonstrated strong antioxidant activity in cell-based (TBARS, OxHLIA) and chemical (DPPH, ABTS, FRAP) assays, particularly EH-MA. Significant antibacterial activity was observed, especially against Enterobacter cloacae, Pseudomonas aeruginosa, and Staphylococcus aureus (MIC 1–10 mg/mL), as well as antifungal activity against Aspergillus brasiliensis (MIC 2–2.5 mg/mL). Selective antiproliferative activity was observed against tumor cell lines Caco-2 and MCF-7 (GI50 25 μg/mL), without cytotoxicity toward nontumor cell lines Vero and PLP2 (GI50 > 400 μg/mL). All extracts inhibited the production of the inflammation mediator NO, with EH-MA showing the most potent effect (IC50 of 35 μg/mL), followed by EH-UA (IC50 of 55 μg/mL). Photoprotective potential was also demonstrated, with SPF values of 19 (EH-MA) and 18 (EH-UA). In conclusion, hop cone residues can yield multifunctional extracts with antioxidant, antimicrobial, antiproliferative, anti-inflammatory, and photoprotective activities, which support their sustainable upcycling for pharmacological, nutraceutical, and cosmetic applications. Full article
(This article belongs to the Special Issue Antioxidant Separation and Identification: Emerging Techniques in the Extraction of Phytogenic Compounds)
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