New Perspectives on Medicinal and Aromatic Plants and Their Isolated Bioactive Compounds

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 2522

Special Issue Editors


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Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, Italy
Interests: natural compounds; polyphenols; plant extracts; functional foods; nutraceuticals; food supplements; pharmacology; toxicology; pharmacognosy; antioxidant activity; anti-inflammatory activity; cytoprotective activity; wound healing activity; photoprotective activity; pharmacokinetic and pharmacodynamic studies; clinical studies; inflammatory bowel disease; circular economy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, Italy
Interests: natural compounds; polyphenols; plant extracts; functional foods; nutraceuticals; food supplements; pharmacology; toxicology; pharmacognosy; antioxidant activity; anti-inflammatory activity; cytoprotective activity; wound healing activity; photoprotective activity; pharmacokinetic and pharmacodynamic studies; clinical studies; inflammatory bowel disease; circular economy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nowadays, the market for phytotherapeutics as well as plant-based food supplements (PFS) is constantly growing. A more holistic approach to treatments, as well as the need to find new alternatives to conventional therapies which often cause significant side effects and consequent therapeutic inefficiency, has inexorably led research to focus on the plant world. Indeed, it represents an inexhaustible source of plant complexes and isolated bioactive compounds capable of preserving the subject's state of health, as in the case of PFS, or assisting conventional therapy and sometimes even replacing or filling some therapeutic gaps, as in the case of phytotherapeutics.

From this point of view, medicinal and aromatic plants represent precious raw materials, still not fully explored, which can actively contribute to scientific research in the phytotherapeutic, nutraceutical and cosmeceutical fields.

The aim of this Special Issue is to collect new scientific evidence in this regard. Original research articles and reviews investigating medicinal and aromatic plants (ornamental, food or traditionally used) through a multidisciplinary approach (macro- and micro-morphological, phytochemical and biological) will be taken into consideration. Particular attention will be given to some critical points regarding the reproducibility of health and therapeutic effects, such as the standardization and titration of plant complexes.

Prof. Dr. Domenico Trombetta
Dr. Antonella Smeriglio
Guest Editors

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Keywords

  • medicinal plants
  • aromatic plants
  • bioactive compounds
  • phytochemicals

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Published Papers (2 papers)

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Research

18 pages, 6491 KiB  
Article
Antioxidant and In Vitro Hepatoprotective Activities of a Polyphenol-Rich Fraction from the Peel of Citrus lumia Risso (Rutaceae)
by Vincenzo Musolino, Antonio Cardamone, Rosario Mare, Anna Rita Coppoletta, Francesca Lorenzo, Francesca Rita Noto, Angelo Galluccio, Luigi Tucci, Carmine Lupia, Cristina Carresi, Mariangela Marrelli, Samantha Maurotti, Micaela Gliozzi, Tiziana Montalcini, Arturo Pujia and Vincenzo Mollace
Plants 2025, 14(8), 1209; https://doi.org/10.3390/plants14081209 - 15 Apr 2025
Viewed by 414
Abstract
Citrus lumia Risso is an ancient, cultivated Mediterranean lime belonging to the Rutaceae family. It is a species extremely difficult to retrieve, but it is still found in some private gardens in certain regions of Southern Italy. Citrus fruits are a rich source [...] Read more.
Citrus lumia Risso is an ancient, cultivated Mediterranean lime belonging to the Rutaceae family. It is a species extremely difficult to retrieve, but it is still found in some private gardens in certain regions of Southern Italy. Citrus fruits are a rich source of bioactive compounds, particularly polyphenols, which have been linked to a reduction in the risk of several metabolic diseases. Here, hesperidium peel extracts were obtained by maceration with ethanol:water mixtures in different proportions (50:50, 80:20, 0:100) and the resulting crude extracts were then passed through a glass column containing adsorbent resins to concentrate the polyphenolic compounds. After phytochemical characterization, the extracts were evaluated for antioxidant activity using electron paramagnetic resonance (EPR) spectroscopy. Finally, the water polyphenolic-rich extract (ClumWp), which was the extract with the highest flavonoid content (18.355 ± 1.607 mg/mL) and the strongest antioxidant activity against hydroxyl radical, was tested to evaluate its potential protective effects on lipid accumulation in both 2D hepatocyte cultures and 3D spheroids. Treatment with 25 and 50 μg/mL resulted in a reduction in intracellular lipid content in the HepG2 liver cell line, while treatment with 100 µg/mL ClumWp resulted in a reduction in the intracellular lipid content in HepG2 + LX2 spheroids. In addition, treatment with ClumWp significantly increased ATP levels in the spheroids compared to those untreated, suggesting its ability to restore and promote ATP production. Our results highlight that the study of neglected species, such as Citrus lumia Risso, remains a valuable opportunity to valorize Mediterranean biodiversity, especially in the context of its potential applications to improve human health. In particular, the polyphenolic fraction of Citrus lumia peel showed promising effects on lipid metabolism and cellular energy balance and may prove valuable in the treatment of metabolic disorders such as MASLD, where lipid accumulation disrupts normal cellular functions. Full article
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22 pages, 3884 KiB  
Article
Beyond the Scent: New Evidence about Micromorphological, Phytochemical and Biological Features of Plumeria rubra ‘Tonda Palermitana’ (Apocynaceae)
by Paola Malaspina, Mariarosaria Ingegneri, Federica Betuzzi, Emilio Di Gristina, Laura Cornara, Domenico Trombetta and Antonella Smeriglio
Plants 2024, 13(17), 2479; https://doi.org/10.3390/plants13172479 - 4 Sep 2024
Cited by 2 | Viewed by 1612
Abstract
Plumeria rubra L. is an ornamental Caribbean plant widely known for its ethnobotanical uses and pharmacological activities. The ‘Tonda Palermitana’ cultivar, on which no data are to date available, is commonly cultivated in Sicily. The aim of our study was to characterize the [...] Read more.
Plumeria rubra L. is an ornamental Caribbean plant widely known for its ethnobotanical uses and pharmacological activities. The ‘Tonda Palermitana’ cultivar, on which no data are to date available, is commonly cultivated in Sicily. The aim of our study was to characterize the micro-morphological features of leaves and flowers of this cultivar by light and Scanning Electron Microscopy and to investigate the phytochemical profile and the biological properties of their food-grade extracts (LE and FE, respectively) by LC-DAD-ESI-MS analysis and different in vitro assays. Numerous branched laticifers were observed, and their secretion contained alkaloids and lipophilic compounds as confirmed by histological analyses. Phytochemical analyses showed the presence of alkaloids (9%), terpenoids (13%) and fatty acids (6%), together with a very abundant presence of iridoids (28%) and polyphenols (39%). The most notable biological activity of both extracts appears to be the antioxidant one, showing half-inhibitory concentrations (IC50) about 5 times lower than those detected in anti-inflammatory assays (383.74 ± 5.65 and 232.05 ± 2.87 vs. 1981.23 ± 12.82 and 1215.13 ± 10.15, for FE and LE, respectively), with LE showing the best, and statistically significant (p < 0.001), biological activity. These results allow us to speculate promising nutraceutical and cosmeceutical applications for this old Sicilian cultivar. Full article
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