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Pathogens
Special Issues
Biomarkers and Therapeutics for Parkinson's Disease
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Biomarkers and Therapeutics for Parkinson's Disease

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Vaccines and Therapeutic Developments".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 2792

Special Issue Editor

Prof. Dr. Seungtae Kim

E-Mail Website
Guest Editor
Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
Interests: Parkinson's disease; pain; acupuncture; medicinal herbs; neuroprotection; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. PD is caused by a loss of nerve cells in the part of the brain called the substantia nigra. This leads to a reduction in a chemical called dopamine in the brain. Dopamine plays a vital role in regulating the movement of the body. A reduction in dopamine is responsible for many of the symptoms of PD.

There is no cure for PD and treatment aims to improve the symptoms. Since there is no accurate test method for PD, the diagnosis of PD is mainly based on symptoms, with tests such as neuroimaging used to rule out other diseases. Therefore, research on biomarkers and various therapeutics for PD is very important in order to establish a PD diagnosis and treatment strategy.

This Special Issue aims to collect original research articles describing in vivo and/or in vitro assays that enhance our understanding of diagnosis and treatment in the field of PD. Of particular interest are studies that illustrate the effect and mechanism of medication, acupuncture, and medicinal herbs on PD. Studies that present strategies including biomarkers for the diagnosis of PD are also welcome.

Dr. Seungtae Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • parkinson’s disease
  • neurodegenerative disease
  • neurodegeneration
  • oxidative stress
  • inflammation
  • biomarker
  • dopamine
  • mitochondria
  • treatment
  • medication
  • acupuncture
  • herb

Published Papers (1 paper)

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Research

15 pages, 4097 KiB  
Article
Co-Administration of Gagam-Sipjeondaebo-Tang and Ibuprofen Alleviates the Inflammatory Response in MPTP-Induced Parkinson’s Disease Mouse Model and RAW264.7 Macrophages
by Sodam Won, Jade Heejae Ko, Hayoung Jeon, Seong-Sik Park and Seung-Nam Kim
Pathogens 2021, 10(3), 268; https://doi.org/10.3390/pathogens10030268 - 26 Feb 2021
Cited by 4 | Viewed by 2453
Abstract
Parkinson’s disease (PD), a common neurodegenerative disease, is characterized by degeneration of dopaminergic neurons with neuroinflammation. Gagam-Sipjeondaebo-Tang (GST), a traditional herbal formula made of twelve medicinal herbs, is known to be effective in PD, and the use of ibuprofen has been associated with [...] Read more.
Parkinson’s disease (PD), a common neurodegenerative disease, is characterized by degeneration of dopaminergic neurons with neuroinflammation. Gagam-Sipjeondaebo-Tang (GST), a traditional herbal formula made of twelve medicinal herbs, is known to be effective in PD, and the use of ibuprofen has been associated with a lower risk of PD. The aim of this study was to evaluate whether the combined administration of GST and ibuprofen affects the inflammatory response of Parkinson’s disease. MPTP-induced parkinsonian mouse models were treated with GST or ibuprofen using oral gavage once a day for 5 days. The effects of GST were examined by measuring the TH level and expression of CD68 in the mice brain in addition to behavioral tests. The anti-inflammatory effect of GST on the LPS-treated RAW264.7 murine macrophages was examined using the NO assay. Inflammatory cytokines were analyzed using quantitative-PCR and flow cytometry. In the results, GST significantly improved the loss of dopaminergic neurons and alleviated PD-induced behavioral deficits. GST also decreased macrophage activation in the MPTP-induced PD mouse model. Interestingly, co-administration of GST and ibuprofen showed a synergistic effect in improving the loss of dopaminergic neurons and decreasing the activation of macrophages. Moreover, the NO level decreased in LPS-stimulated macrophages with this combined treatment. GST reduced iNOS, COX-2, IL-1β, and IL-6 levels, and co-administration with ibuprofen showed a synergistic effect. Furthermore, pretreatment of GST reduced the expression levels of MCP-1 and IL-12 p70 in LPS-stimulated RAW264.7 cells. These results can possibly suggest a future therapeutic approach for PD patients. Full article
(This article belongs to the Special Issue Biomarkers and Therapeutics for Parkinson's Disease)
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