Special Issue "Deciphering Trypanosomatids by Using Molecular Biology and Omics Methods"

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 31 December 2022 | Viewed by 903

Special Issue Editor

Dr. Maria Carolina Elias
E-Mail Website
Guest Editor
Laboratório de Ciclo Celular, Instituto Butantan, Sao Paulo, Brazil
Interests: DNA replication and its modulation in Trypanosoma; source of genetic variability, replication origins, transcription-replication conflicts

Special Issue Information

Dear Colleagues,

Trypanosomatids belong to a group of unicellular parasites of considerable medical importance. These organisms have a peculiar molecular physiology, which makes them interesting models for studying non-canonical pathways in cellular functioning. Molecular biology, at first, and omics later have contributed to understanding the biology and pathogenicity of these organisms. In this Special Issue, we intend to provide an overview of the most recent advances in these areas, putting together the focal approach given by molecular biology with the global view achieved by the study of omics in trypanosomatids.

Potential topics include but are not limited to:

Genome organization;

DNA replication and repair;

Transcription regulation;

Protein synthesis;

Cell signaling;

Cell metabolism and bioenergetics;

Life cycle, cell cycle and differentiation.

Dr. Maria Carolina Elias
Guest Editor

Manuscript Submission Information

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Keywords

  • trypanosomatids
  • DNA replication
  • DNA repair
  • gene expression
  • protein synthesis
  • metabolism
  • cell signaling

Published Papers (1 paper)

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Research

Article
The Importance of Glycerophospholipid Production to the Mutualist Symbiosis of Trypanosomatids
Pathogens 2022, 11(1), 41; https://doi.org/10.3390/pathogens11010041 - 31 Dec 2021
Cited by 1 | Viewed by 362
Abstract
The symbiosis in trypanosomatids is a mutualistic relationship characterized by extensive metabolic exchanges between the bacterium and the protozoan. The symbiotic bacterium can complete host essential metabolic pathways, such as those for heme, amino acid, and vitamin production. Experimental assays indicate that the [...] Read more.
The symbiosis in trypanosomatids is a mutualistic relationship characterized by extensive metabolic exchanges between the bacterium and the protozoan. The symbiotic bacterium can complete host essential metabolic pathways, such as those for heme, amino acid, and vitamin production. Experimental assays indicate that the symbiont acquires phospholipids from the host trypanosomatid, especially phosphatidylcholine, which is often present in bacteria that have a close association with eukaryotic cells. In this work, an in-silico study was performed to find genes involved in the glycerophospholipid (GPL) production of Symbiont Harboring Trypanosomatids (SHTs) and their respective bacteria, also extending the search for trypanosomatids that naturally do not have symbionts. Results showed that most genes for GPL synthesis are only present in the SHT. The bacterium has an exclusive sequence related to phosphatidylglycerol production and contains genes for phosphatidic acid production, which may enhance SHT phosphatidic acid production. Phylogenetic data did not indicate gene transfers from the bacterium to the SHT nucleus, proposing that enzymes participating in GPL route have eukaryotic characteristics. Taken together, our data indicate that, differently from other metabolic pathways described so far, the symbiont contributes little to the production of GPLs and acquires most of these molecules from the SHT. Full article
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