Arboviruses Infections and Pathogenesis

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 791

Special Issue Editors


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Guest Editor
Laboratorio Nacional de Vacunología y Virus Tropicales (LNVyVT), México City 11340, Mexico
Interests: dengue; immunopathogenesis; polymorphisms; virus vectors; reservoirs

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Guest Editor
Research Unit on Virology and Cancer, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico
Interests: innate receptors; flavivirus; dengue viruses; arbovirus; host–pathogen interactions; B-lymphocytes

Special Issue Information

Dear Colleagues,

Arboviruses are a group of viruses that are transmitted to vertebrate hosts by hematophagous arthropod vectors. These vectors are commonly mosquitoes, ticks, sandy flies, and other arthropods. Arboviruses, such as the dengue virus (DENV); yellow fever virus (YFV); Chikungunya virus (CHIKV); Zika virus (ZIKV); Japanese Encephalitis Virus (JEV); and Rift Valley fever virus, etc., can affect both humans and animals causing great concern for public health worldwide for potential emergent or re-emergent diseases, with epidemic outbreaks and the introduction of the endemic circulation of species previously confined to tropical and subtropical regions. Although many efforts have been made to improve our understanding of arbovirus infection, our current knowledge is still limited. A better understanding of arbovirus infections and pathogenesis would be of great significance for developing diagnostics, control and prevention, and the treatment of arboviral diseases.

This Special Issue will focus on and cover a wide range of topics about arboviruses ,including recent advances in understanding the pathogenesis of arbovirus, its molecular interactions with host cells, and new developments in diagnostic methods and therapeutic strategies, research articles, and review articles related to the topic are welcome.

We look forward to receiving your contributions.

Prof. Dr. Ma. Isabel Salazar Sánchez
Dr. Diana Alhelí Domínguez-Martínez
Guest Editors

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Keywords

  • arboviruses
  • arbovirus–host interactions
  • immune response against arbovirus
  • arboviral diseases
  • virulence
  • arthropod vectors
  • viral pathogenesis
  • dengue virus
  • antiviral drugs and vaccines
  • emergent or re-emergent diseases

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Published Papers (1 paper)

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Review

15 pages, 879 KB  
Review
Preclinical Models of Oropouche Virus Infection and Disease
by Daniel Morley, Emma Kennedy and Stuart Dowall
Pathogens 2025, 14(12), 1272; https://doi.org/10.3390/pathogens14121272 - 11 Dec 2025
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Abstract
Oropouche virus (OROV) is an emerging and underreported arbovirus with dengue-like symptoms confounding diagnosis. OROV is also neuroinvasive, with a small number of cases presenting severe neurological symptoms. There have been recently reported deaths from confirmed cases of OROV and reported instances of [...] Read more.
Oropouche virus (OROV) is an emerging and underreported arbovirus with dengue-like symptoms confounding diagnosis. OROV is also neuroinvasive, with a small number of cases presenting severe neurological symptoms. There have been recently reported deaths from confirmed cases of OROV and reported instances of vertical transmission from mother to foetus, with confirmed cases in Brazil and a congenital anomaly, reportedly as a consequence of OROV infection in Cuba, with further cases under investigation. Whilst cases of OROV infection occur mainly in South America, many cases have been imported elsewhere, including the United States and Europe. Despite the emerging threat to public health, animal modelling to study OROV pathogenicity and immunity and to evaluate therapeutic candidates remains limited. For this review, we carried out a literature search through major research databases (PubMed and Scopus) up to September 2025 to capture the extent of in vivo model development for this pathogen. We identified only 17 relevant primary research articles within these criteria which detailed hamster, mouse and non-human primate (NHP) models. Here, we discuss the extent of in vivo model development for OROV. In summary, small and large animal models need to be assessed with recent clinical isolates and reassortants, asymptomatic disease presentation in the NHP model requires further study and the hamster model shows potential for use in pathogenicity and vaccine or antiviral efficacy studies. We also compile relevant metadata and discuss the need for an animal model that more closely resembles human disease. Full article
(This article belongs to the Special Issue Arboviruses Infections and Pathogenesis)
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