Celiac Disease and Nonceliac Gluten Sensitivity: Update of the Pathophysiology, Diagnosis and Treatment

Dear Colleagues,

The avoidance of wheat- and gluten-containing products is a worldwide phenomenon, because the prevalence of gluten-related disorders is rising, and increasing numbers of individuals are empirically trying a gluten-free diet for a variety of signs and symptoms. Celiac disease (CD) is a common immune-mediated enteropathy characterized by gluten-induced small intestinal damage with loss of absorptive villi in genetically susceptible individuals. On the other hand, nonceliac gluten sensitivity (also referred to as wheat intolerance syndrome) is diagnosed in individuals who do not have celiac disease or wheat allergy but who have symptoms related to ingestion of gluten-containing grains, with symptomatic improvement on their withdrawal. However, while celiac disease is well-established, much remains unknown about how and whether gluten can be a trigger of gastrointestinal and/or extra-intestinal symptoms in patients without celiac disease. In addition, many questions remain unanswered, and although both conditions are treated with a gluten-free diet, distinguishing between celiac disease and nonceliac gluten sensitivity is important for long-term therapy.

The list of topics to be covered should deal with this exciting and evolving field, covering updated information concerning pathogenesis, role of the gut microbiota, evolving clinical presentations, diagnostic approaches, and new treatments appearing on the horizon.

Prof. Dr. Antonio Gasbarrini
Prof. Dr. Giovanni Cammarota
Guest Editors

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