Micronutrient Malnutrition, Infection, and Immunity in Children

Dear Colleagues,

The synergism between nutrition and infectious diseases substantially contributes to the childhood burden of disease in low- and middle-income countries. Clinical and population studies have addressed the spectrum of nutritional deficiencies and the multitude of infectious agents that can comprise this synergism. The papers to be included in the proposed book will examine these relationships at different scales and apply innovative analytical techniques to provide a better understanding of the causal pathways linking nutritional status and infectious disease. The first chapters will be concerned with how nutritional status either through diet or through nutritional interventions affects the gut microbiome and enteric infections among young children. The impact of children’s nutritional status on the immune response that underlies these relationships will also be addressed in these chapters. Causal associations between childhood stunting and specific enteric infections in the household environment will be examined in the next chapter using structural linear models. The association of soil-transmitted helminths and childhood malnutrition will then be explored at regional levels in Sub-Saharan Africa through spatial modeling techniques. These studies presented in these chapters will provide an overview and further understanding of the causal relationships between malnutrition and infectious diseases that can inform efforts to more systematically reduce childhood disease burden.

Dr. Kurt Long
Dr. Helen Powell
Dr. Johanna Sanchez
Guest Editors

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