Special Issue "Plant Bioactive Compounds for Health Benefits and Nutrition"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 31 May 2020.

Special Issue Editors

Prof. Dr. Patricia Morales
E-Mail
Guest Editor
Department of Nutrition and Food Science, Complutense University of Madrid, Spain
Interests: food science and technology; natural food matrix; food additives; functional foods and ingredients
Special Issues and Collections in MDPI journals
Prof. Dr. Virginia Fernández-Ruiz
E-Mail Website
Guest Editor
Department Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain
Interests: plant food bioactive compounds; chemical and sensory food analysis; nutrition

Special Issue Information

Dear Colleagues,

In this Special Issue of Nutrients, we would like to bring together papers dealing with the topic of plant bioactive compounds for health benefits and nutrition. In broad terms, the study of bioactive compounds, health, and nutrition may focus on different bioactive compounds present in vegetables, their intake, health effects, reduction of disease risk, as well as effects on disease biomarkers.

The average life expectancy has increased significantly with medical advances and economic progress, and with it, the concern about health and nutrition. Sedentary lifestyles and dietary factors contribute to the burden of illnesses and deaths. In fact, dietary factors are related to 4 of the 10 principal causes of death: coronary heart disease, some types of cancer, stroke, type 2 diabetes.

Besides, it is estimated that about 3 to 4 million cases of cancer could be avoided every year with an adequate and healthy food intake and nutrition, regular physical activity, and avoidance of obesity. In this context, functional foods, which contain components, nutrients, or bioactive compounds exerting selective beneficial effects on one or more functions of the organism, are widely distributed in the food market. Health claims are important value-added features for consumers and therefore for the food industry, since they can give a competitive advantage to a food product and can differentiate food products in the market. The EFSA accepts only health claims based on accepted scientific evidence. Therefore, further research is required to provide strong scientific evidence of the association between functional foods containing bioactive compounds and human health.

We welcome different types of manuscripts, including original research articles and up-to-date reviews (systematic reviews and meta-analyses).

Topics may include, but are not limited to, the associations of bioactive compounds present in foods, their intake, and nutritional biomarkers with reduction of disease risk, cancer, cardiovascular disease, obesity, high blood pressure, as well as other diseases.

Prof. Dr. Virginia Fernández-Ruiz
Prof. Dr. Patricia Morales
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive compounds
  • phenolics
  • antioxidants
  • carotenoids
  • health claims
  • nutrition
  • reduction of disease risk
  • DNA protection
  • proteins protection
  • lipids damage

Published Papers (6 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

Open AccessArticle
Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
Nutrients 2020, 12(3), 773; https://doi.org/10.3390/nu12030773 (registering DOI) - 14 Mar 2020
Abstract
The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) and its bioactive components on inflammation and insulin [...] Read more.
The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) and its bioactive components on inflammation and insulin sensitivity. PRE inhibited TNF-α-induced NF-κB transcriptional activity in the NF-κB luciferase assay and pro-inflammatory genes’ expression by blocking phosphorylation of IκB and NF-κB in 3T3-L1 adipocytes, which were mediated by activating AMPK. Ten-week-high fat diet (HFD)-fed C57BL6 male mice treated with PRE had improved glucose intolerance and decreased inflammation in adipose tissue, as indicated by reductions in NF-κB phosphorylation and pro-inflammatory genes’ expression. Furthermore, PRE activated AMP-activated protein kinase (AMPK) and reduced lipogenic genes’ expression in both adipose tissue and liver. Finally, we identified broussoflavonol B (BF) and kazinol J (KJ) as bioactive constituents to suppress pro-inflammatory responses via activating AMPK in 3T3-L1 adipocytes. Taken together, these results indicate the therapeutic potential of PRE, especially BF or KJ, in metabolic diseases such as obesity and type 2 diabetes. Full article
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
Show Figures

Graphical abstract

Open AccessArticle
Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation
Nutrients 2020, 12(3), 677; https://doi.org/10.3390/nu12030677 - 02 Mar 2020
Abstract
Chronic exposure to cisplatin is associated with irreversible kidney impairment. In this present study, we explored the protective effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from roots of jujube (Ziziphus jujuba, Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithelial [...] Read more.
Chronic exposure to cisplatin is associated with irreversible kidney impairment. In this present study, we explored the protective effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from roots of jujube (Ziziphus jujuba, Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithelial LLC-PK1 cells, western blotting and staining with specific autophagy epifluorescent dye CytoID were used to determine the molecular pathways involving autophagy. Treatment with 3DC2ME reduced the increased Cyto-ID-stained autophagic vesicles and reversed the protein expressions of 5’ AMP-activated protein kinase subunit β-1 (AMPK)/mammalian target of rapamycin (mTOR)-dependent signaling pathway in cisplatin-induced cell death. Additionally, treatment with autophagy inhibitor 3-methyladenine (3-MA) and with or without 3DC2ME attenuated the cisplatin-induced apoptosis. Although further research is necessary to substantiate the effects, we evaluated the potential mechanism of action of 3DC2ME as an adjuvant for cancer patients. Full article
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
Show Figures

Graphical abstract

Open AccessArticle
Influence of Pomace Matrix and Cyclodextrin Encapsulation on Olive Pomace Polyphenols’ Bioaccessibility and Intestinal Permeability
Nutrients 2020, 12(3), 669; https://doi.org/10.3390/nu12030669 - 29 Feb 2020
Abstract
Olive pomace is a rich source of biologically active compounds, mainly polyphenols. Recently, an efficient and sustainable cyclodextrin (CD)-enhanced extraction was developed. It enabled a relatively simple formulation of high-quality olive pomace extracts (OPEs) that can be used as alternative sources of olive-derived [...] Read more.
Olive pomace is a rich source of biologically active compounds, mainly polyphenols. Recently, an efficient and sustainable cyclodextrin (CD)-enhanced extraction was developed. It enabled a relatively simple formulation of high-quality olive pomace extracts (OPEs) that can be used as alternative sources of olive-derived polyphenols in the nutrition and pharma industries. However, biological effects and nutraceutical potential of OPEs are primarily limited by generally low oral bioavailability of major polyphenols (hydroxytyrosol and its derivatives) that can be significantly influenced by OPE matrix and the presence of CDs in formulation. The major goal of this research was to investigate the impact of complex matrix and different types of CDs on gastrointestinal stability and intestinal permeability of major OPE polyphenols, and provide additional data about mechanisms of absorption and antioxidant activity in gut lumen. Obtained results showed high bioaccessibility but relatively low permeability of OPE polyphenols, which was negatively affected by OPE matrix. CDs improved antioxidant efficiency of tested OPEs and tyrosol gastrointestinal stability. Effects of CDs on permeability and the metabolism of particular OPE polyphenols were CD- and polyphenol-specific. Full article
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
Show Figures

Figure 1

Open AccessArticle
Potential Health Claims of Durum and Bread Wheat Flours as Functional Ingredients
Nutrients 2020, 12(2), 504; https://doi.org/10.3390/nu12020504 - 17 Feb 2020
Abstract
Wheat is an important cereal with a key role in human nutrition. In this study, dietary fiber (DF) and arabinoxylans of different durum (Triticum turgidum ssp. Durum L.) and bread (Triticum aestivum L.) wheat flours were analyzed in order to point [...] Read more.
Wheat is an important cereal with a key role in human nutrition. In this study, dietary fiber (DF) and arabinoxylans of different durum (Triticum turgidum ssp. Durum L.) and bread (Triticum aestivum L.) wheat flours were analyzed in order to point out their potential nutritional and health claims allege according to the current European regulation (Regulation (EU) No 432/2012). Moreover, other bioactive compounds (phenolics and tocopherols) were quantified as a first approach to their phytochemical composition in the analyzed wheat varieties. DF was analyzed following AOAC enzymatic-gravimetric methods; arabinoxylans and total phenols were quantified by colorimetric methods; tocopherols were determined by HPLC; antioxidant activity was evaluated using three different in vitro assays. Insoluble DF was the prevailing fraction in all analyzed samples. Water extractable arabinoxylans were higher in durum wheat flours. Whole flours contained higher total phenolics compounds. Alpha-tocopherol was the major isoform. Whole flours showed higher antioxidant properties. According to the obtained results, it is possible to allege all approved health claims referred to wheat, since all analyzed samples, especially whole flour and bran fraction, showed potential health benefits, as functional ingredients or functional foods, related with their phytochemical composition. Full article
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
Show Figures

Graphical abstract

Open AccessArticle
Chemical Profile, Antioxidative, and Gut Microbiota Modulatory Properties of Ganpu Tea: A Derivative of Pu-erh Tea
Nutrients 2020, 12(1), 224; https://doi.org/10.3390/nu12010224 - 15 Jan 2020
Abstract
Ganpu tea is an emerging tea drink produced from Pu-erh tea and the pericarp of Citrus reticulate Chachi (GCP). Recently, it has been increasingly favored by consumers due to the potential health effects and special taste. However, information concerning its chemical profile and [...] Read more.
Ganpu tea is an emerging tea drink produced from Pu-erh tea and the pericarp of Citrus reticulate Chachi (GCP). Recently, it has been increasingly favored by consumers due to the potential health effects and special taste. However, information concerning its chemical profile and biological activities is scarce. In this work, a total of 92 constituents were identified in hot-water extracts of Ganpu tea with ultra-high performance liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS). Moreover, the antioxidative and gut microbiota modulatory properties of Ganpu tea were investigated in rats after long-term dietary consumption. Ganpu tea and GCP could significantly enhance the activities of superoxide dismutase (SOD) by 13.4% (p < 0.05) and 15.1% (p < 0.01), as well as the activities of glutathione peroxidase (GSH-Px) by 16.3% (p < 0.01) and 20.5% (p < 0.01), respectively. Both showed better antioxidant capacities than Pu-erh tea. Ganpu tea increased the abundance of Bifidobacterium, Lactobacillus, and Lactococcus, suggesting the potential of Ganpu tea in modulating the gut microbiota to benefit human health. The obtained results provide essential information for further investigation of Ganpu tea. Full article
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
Show Figures

Graphical abstract

Review

Jump to: Research

Open AccessReview
Phenolic Composition, Mineral Content, and Beneficial Bioactivities of Leaf Extracts from Black Currant (Ribes nigrum L.), Raspberry (Rubus idaeus), and Aronia (Aronia melanocarpa)
Nutrients 2020, 12(2), 463; https://doi.org/10.3390/nu12020463 - 12 Feb 2020
Cited by 1
Abstract
Currently, the incidence of lifestyle diseases is increasing due to inappropriate nutrition and environmental pollution. To prevent these diseases, various groups of bioactive compounds are needed with a broad spectrum of action and without adverse side effects. Polyphenolic compounds are the most widely [...] Read more.
Currently, the incidence of lifestyle diseases is increasing due to inappropriate nutrition and environmental pollution. To prevent these diseases, various groups of bioactive compounds are needed with a broad spectrum of action and without adverse side effects. Polyphenolic compounds are the most widely studied group of this type of compounds. They occur widely in plants, but their content depends on many factors, including the type of plant, climatic conditions, and the date of harvest. The spectrum of bioactivity of phenolic compounds is determined by their chemical structure, concentration, and interaction with other compounds. Traditional recipes have been studied to search for active plant ingredients. Leaves of shrubs and fruit trees were used in folk medicine as a panacea for many diseases and have been forgotten with time, but their benefits are now being rediscovered. In recent years, much new information about biological activity of phenolic compounds from berry bushes (black currant, raspberry, and aronia) was published. This was reviewed and discussed in this article. The mineral content of their leaves was also summarized because minerals constitute a significant component of plant infusions. It has been shown that high antioxidant and biological activity of leaf extracts results from the presence of active phenolic compounds, which occur in definitely higher amounts than in fruits. Therefore, the leaves of berry bushes seem to be a promising source of substances that can be used as replacements for synthetic agents in the treatment and prevention of lifestyle diseases. Full article
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
Show Figures

Graphical abstract

Back to TopTop