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Review

Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews

1
Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia
2
Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia, Kuantan 25200, Malaysia
3
Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
4
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2584; https://doi.org/10.3390/nu12092584
Received: 8 July 2020 / Revised: 19 July 2020 / Accepted: 20 July 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
Picrasma quassioides is a member of the Simaroubaceae family commonly grown in the regions of Asia, the Himalayas, and India and has been used as a traditional herbal medicine to treat various illnesses such as fever, gastric discomfort, and pediculosis. This study aims to critically review the presence of phytochemicals in P. quassioides and correlate their pharmacological activities with the significance of its use as traditional medicine. Data were collected by reviewing numerous scientific articles from several journal databases on the pharmacological activities of P. quassioides using certain keywords. As a result, approximately 94 phytochemicals extracted from P. quassioides were found to be associated with quassinoids, β-carbolines and canthinones. These molecules exhibited various pharmacological benefits such as anti-inflammatory, antioxidant, anti-cancer, anti-microbial, and anti-parasitic activities which help to treat different diseases. However, P. quassioides were also found to have several toxicity effects in high doses, although the evidence regarding these effects is limited in proving its safe use and efficacy as herbal medicine. Accordingly, while it can be concluded that P. quassioides may have many potential pharmacological benefits with more phytochemistry discoveries, further research is required to determine its real value in terms of quality, safety, and efficacy of use. View Full-Text
Keywords: Picrasma quassioides; Simaroubaceae; anti-inflammatory; antioxidant; anti-malarial; antifeedant; anti-cancer; anti-ulcer; quassinoids Picrasma quassioides; Simaroubaceae; anti-inflammatory; antioxidant; anti-malarial; antifeedant; anti-cancer; anti-ulcer; quassinoids
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MDPI and ACS Style

Mohd Jamil, M.D.H.; Taher, M.; Susanti, D.; Rahman, M.A.; Zakaria, Z.A. Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews. Nutrients 2020, 12, 2584. https://doi.org/10.3390/nu12092584

AMA Style

Mohd Jamil MDH, Taher M, Susanti D, Rahman MA, Zakaria ZA. Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews. Nutrients. 2020; 12(9):2584. https://doi.org/10.3390/nu12092584

Chicago/Turabian Style

Mohd Jamil, Muhammad D.H., Muhammad Taher, Deny Susanti, Md A. Rahman, and Zainul A. Zakaria 2020. "Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews" Nutrients 12, no. 9: 2584. https://doi.org/10.3390/nu12092584

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