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Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation

1
Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea
2
Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheong-ju si, Chungcheongbuk−do 28116, Korea
3
Department of Internal Medicine, Seoul National University, Seoul 110-744, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(3), 773; https://doi.org/10.3390/nu12030773
Received: 5 February 2020 / Revised: 12 March 2020 / Accepted: 13 March 2020 / Published: 14 March 2020
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) and its bioactive components on inflammation and insulin sensitivity. PRE inhibited TNF-α-induced NF-κB transcriptional activity in the NF-κB luciferase assay and pro-inflammatory genes’ expression by blocking phosphorylation of IκB and NF-κB in 3T3-L1 adipocytes, which were mediated by activating AMPK. Ten-week-high fat diet (HFD)-fed C57BL6 male mice treated with PRE had improved glucose intolerance and decreased inflammation in adipose tissue, as indicated by reductions in NF-κB phosphorylation and pro-inflammatory genes’ expression. Furthermore, PRE activated AMP-activated protein kinase (AMPK) and reduced lipogenic genes’ expression in both adipose tissue and liver. Finally, we identified broussoflavonol B (BF) and kazinol J (KJ) as bioactive constituents to suppress pro-inflammatory responses via activating AMPK in 3T3-L1 adipocytes. Taken together, these results indicate the therapeutic potential of PRE, especially BF or KJ, in metabolic diseases such as obesity and type 2 diabetes. View Full-Text
Keywords: Broussonetia papyrifera root bark; adipocyte; inflammation; AMPK; insulin sensitivity Broussonetia papyrifera root bark; adipocyte; inflammation; AMPK; insulin sensitivity
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MDPI and ACS Style

Lee, J.M.; Choi, S.S.; Park, M.H.; Jang, H.; Lee, Y.H.; Khim, K.W.; Oh, S.R.; Park, J.; Ryu, H.W.; Choi, J.H. Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation. Nutrients 2020, 12, 773. https://doi.org/10.3390/nu12030773

AMA Style

Lee JM, Choi SS, Park MH, Jang H, Lee YH, Khim KW, Oh SR, Park J, Ryu HW, Choi JH. Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation. Nutrients. 2020; 12(3):773. https://doi.org/10.3390/nu12030773

Chicago/Turabian Style

Lee, Jae M., Sun S. Choi, Mi H. Park, Hyunduk Jang, Yo H. Lee, Keon W. Khim, Sei R. Oh, Jiyoung Park, Hyung W. Ryu, and Jang H. Choi. 2020. "Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation" Nutrients 12, no. 3: 773. https://doi.org/10.3390/nu12030773

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