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Article

Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

1
KGK Science Inc., London, ON N6A 5R8, Canada
2
LifeSeasons, Inc., Springville, UT 84663, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1831; https://doi.org/10.3390/nu12061831
Received: 11 May 2020 / Revised: 10 June 2020 / Accepted: 11 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Plant Bioactive Compounds for Health Benefits and Nutrition)
The lack of effective treatment for chronic discomfort without negative side effects highlights the need for alternative treatments. Pain Bloc-R is a natural health product composed of vitamins B6, B12, D, white willow bark extract, Angelica root extract, acetyl L-carnitine HCl, caffeine, L-theanine, Benfotiamine, and L-tetrahydropalmatine. The objective of this study was to compare the effects of Pain Bloc-R, acetaminophen, and placebo on unresolved aches and discomfort as assessed by the brief pain inventory (BPI) and modified Cornell musculoskeletal discomfort questionnaires. This randomized, double-blind, placebo-controlled, crossover study consisted of three 7-day periods with Pain Bloc-R, acetaminophen, or placebo, each separated by a 7-day washout. Twenty-seven healthy adults (ages 22–63 years) were randomized to receive the three interventions in different sequences. The BPI “pain at its worst” scores were significantly lower when participants took Pain Bloc-R than when they took acetaminophen (21.8% vs. 9.8% decrease, p = 0.026) after seven days of supplementation. Pain Bloc-R achieved a significant improvement in the “pain at its least” score, significantly decreased the interference of discomfort in walking, and significantly decreased musculoskeletal discomfort total scores (34%, p = 0.040) after seven days. In a post hoc subgroup analysis based on age and gender, male participants ≤45 years taking Pain Bloc-R reported significant reductions in pain severity and pain interference vs. acetaminophen. Pain Bloc-R performed as well as acetaminophen in managing unresolved non-pathological pain in otherwise healthy individuals. View Full-Text
Keywords: pain; ache; discomfort; natural health product; randomized controlled trial pain; ache; discomfort; natural health product; randomized controlled trial
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MDPI and ACS Style

Evans, M.; Sulley, A.M.; Crowley, D.C.; Langston, J.; Guthrie, N. Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Nutrients 2020, 12, 1831. https://doi.org/10.3390/nu12061831

AMA Style

Evans M, Sulley AM, Crowley DC, Langston J, Guthrie N. Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Nutrients. 2020; 12(6):1831. https://doi.org/10.3390/nu12061831

Chicago/Turabian Style

Evans, Malkanthi, Abdul M. Sulley, David C. Crowley, Jamie Langston, and Najla Guthrie. 2020. "Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study" Nutrients 12, no. 6: 1831. https://doi.org/10.3390/nu12061831

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