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Gender-Specific Nutrition: Insights into Cardiometabolic Health and Disease Prevention

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (25 August 2025) | Viewed by 3202

Special Issue Editors


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Guest Editor
1. Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Open University, 00166 Rome, Italy
2. Laboratory of Cardiovascular Endocrinology, San Raffaele Research Institute, IRCCS San Raffaele, Via di Val Cannuta, 247, 00166 Rome, Italy
Interests: adipose tissue; human nutrition; Mediterranean diet; ketogenic diet; insulin resistance; physical exercise; metabolism
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy
Interests: obesity; sports nutrition; bariatric surgery; body composition; Mediterranean diet; clinical nutrition
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Open University, 00166 Rome, Italy
2. Laboratory of Cardiovascular Endocrinology, San Raffaele Research Institute, IRCCS San Raffaele, Via di Val Cannuta, 247, 00166 Rome, Italy
Interests: adipose tissue; human nutrition; Mediterranean diet; ketogenic diet; nutraceuticals; physical exercise; metabolism; brown adipose tissue function
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Gender-Specific Nutrition: Insights into Cardiometabolic Health and Disease Prevention”, will examine the influence of gender differences on nutrition and the prevention of cardiometabolic diseases. It will deepen our shared understanding of the interplay between nutritional factors and biological sex, addressing implications for weight management, metabolism, insulin resistance, and dietary impacts, including the Mediterranean and ketogenic diets. This Special Issue invites clinical studies, reviews, and experimental research that showcase personalized nutritional strategies and their potential for enhancing health and preventing disease, with a focus on gender-specific physiological characteristics. 

Dr. Alessandra Feraco
Prof. Dr. Mauro Lombardo
Dr. Andrea Armani
Guest Editors

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Keywords

  • gender-specific nutrition
  • cardiometabolic health
  • Mediterranean diet
  • ketogenic diet
  • insulin resistance
  • metabolism
  • personalized nutrition
  • physical exercise
  • obesity management

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Published Papers (3 papers)

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Research

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16 pages, 1390 KB  
Article
Gender-Specific Interactions Between Adiposity, Alcohol Consumption, and Biological Stress Biomarkers Among College Students in the United States
by Oladayo E. Apalowo, Meghan O’Dwyer, Edirisa J. Nsubuga, Leah Pylate, Abeer M. Alardawi, Nicole Reeder, Frank Kiyimba, Terezie Tolar-Peterson, Wes Schilling and Joel J. Komakech
Nutrients 2025, 17(16), 2640; https://doi.org/10.3390/nu17162640 - 14 Aug 2025
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Abstract
Background: Obesity is a well-documented risk factor for cardiometabolic diseases associated with insulin resistance. However, research on its relationship with alcohol intake and stress markers, such as cortisol and α-amylase, remains limited, particularly among young adults in the general population. Objective: This study [...] Read more.
Background: Obesity is a well-documented risk factor for cardiometabolic diseases associated with insulin resistance. However, research on its relationship with alcohol intake and stress markers, such as cortisol and α-amylase, remains limited, particularly among young adults in the general population. Objective: This study investigated the relationship between adiposity measures, alcohol intake, and biological stress biomarkers among college students. Methods: Participants (n = 189) completed the NIH Diet History Questionnaire II. Body composition was measured via bioelectrical impedance analysis. Salivary α-amylase (sAA) activity and cortisol (sCort) were assessed using the Salimetrics α-amylase kinetic enzyme assay and enzyme immunoassay kits, respectively. Multivariable linear regression models were used to determine the association between alcohol consumption and adiposity on biological stress biomarkers. Results: Among students who were overweight and obese, higher alcohol consumption increased sAA activity (β = 1.52, p = 0.030), with a greater effect in females (β = 2.24, p = 0.012). Body fat percentage showed similar patterns with sAA activity (β = 2.20, p = 0.015), with no significant effect in males. There was no significant interaction between BMI or body fat and alcohol consumption on sCort levels. However, significant main effects were observed for African Americans (β = 0.22, p = 0.020) and overweight and obese status (β = −0.19, p = 0.025) on male students’ sCort levels. African Americans (β = 0.21, p = 0.026) and young male adults within the underfat category (β = 0.35, p = 0.022) also exhibited increased sCort levels. Conclusion: Sex-specific patterns in physiological responses between males and females revealed stronger associations in females for sAA activity and distinct patterns in sCort levels among African American males. Full article
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14 pages, 2247 KB  
Article
Gender-Specific Dietary and Lifestyle Patterns Associated with Cardiometabolic Risk: A Cross-Sectional Analysis
by Mauro Lombardo, Jesse C. Krakauer, Nir Y. Krakauer, Massimiliano Caprio, Andrea Armani and Alessandra Feraco
Nutrients 2025, 17(10), 1705; https://doi.org/10.3390/nu17101705 - 17 May 2025
Cited by 1 | Viewed by 984
Abstract
Background: Gender differences in dietary patterns and lifestyle behaviours may influence abdominal adiposity and cardiometabolic risk, but comprehensive analyses integrating these factors remain limited. Methods: We conducted a cross-sectional study including 1631 adults recruited from a centre specialising in nutrition and metabolic health. [...] Read more.
Background: Gender differences in dietary patterns and lifestyle behaviours may influence abdominal adiposity and cardiometabolic risk, but comprehensive analyses integrating these factors remain limited. Methods: We conducted a cross-sectional study including 1631 adults recruited from a centre specialising in nutrition and metabolic health. Food intake was assessed by 7-day food diaries and lifestyle behaviours were assessed by structured questionnaires. Z scores of a body shape index (zABSI) were calculated as a marker of abdominal adiposity. zABSI represents the standardised value of ABSI, an index specifically designed to assess abdominal adiposity independently of BMI Multivariable linear regression models, stratified by sex and adjusted for age, examined associations between dietary patterns, physical activity and zABSI. Results: Higher intake of plant-based protein was significantly associated with lower zABSI values in women (β = −0.052, p = 0.0053) but not in men (β = −0.015, p = 0.2675). Stratified analyses revealed that women in the middle tertile of plant-based protein intake showed significantly lower zABSI values than men. Combined analyses showed that women classified as physically active and high consumers of plant-based protein had the most favourable abdominal adiposity profiles (p = 0.0036). Participation in endurance and strength sports was associated with lower zABSI values in both sexes, whereas women engaged in team sports had the lowest zABSI values. No significant interaction terms between sex and lifestyle were identified; however, male sex remained an independent predictor of higher zABSI values. Conclusions: In this cross-sectional study, plant-based dietary patterns and physical activity were associated with lower abdominal adiposity, especially among women. These findings suggest the importance of gender-specific strategies to address cardiometabolic risk and emphasise the need for prospective studies to confirm these associations and clarify the underlying mechanisms. Full article
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Review

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23 pages, 1114 KB  
Review
Sex Differences in Vitamin Metabolism and Their Role in Oxidative Stress Regulation and Cardiometabolic Health
by Joanna Wróblewska, Anna Długosz, Marcin Wróblewski, Jarosław Nuszkiewicz, Weronika Wróblewska and Alina Woźniak
Nutrients 2025, 17(16), 2697; https://doi.org/10.3390/nu17162697 - 20 Aug 2025
Cited by 1 | Viewed by 1337
Abstract
Vitamins A, D, E, K, B2, B12, and C play a key role in regulating metabolism and oxidative stress, significantly impacting cardiometabolic health. This review uniquely integrates mechanistic and epidemiological data to examine sex-specific differences in the bioavailability, metabolism, and physiological effects of [...] Read more.
Vitamins A, D, E, K, B2, B12, and C play a key role in regulating metabolism and oxidative stress, significantly impacting cardiometabolic health. This review uniquely integrates mechanistic and epidemiological data to examine sex-specific differences in the bioavailability, metabolism, and physiological effects of these vitamins. By linking hormonal and genetic factors with oxidative stress modulation, lipid metabolism, and endothelial function, we outline how individualized vitamin intake strategies may help prevent cardiovascular and metabolic disorders. The paper also identifies natural dietary sources and optimal intake recommendations for each vitamin, emphasizing the importance of tailoring supplementation to sex-related needs. This sex-focused perspective provides a basis for developing personalized nutrition approaches to optimize cardiometabolic outcomes. Full article
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