Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
Dietary Patterns, Gut Microbiome and Cardiometabolic Diseases
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Dietary Patterns, Gut Microbiome and Cardiometabolic Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 7960

Special Issue Editors

Dr. Maria Annunziata Carluccio

E-Mail Website
Guest Editor
National Research Council (CNR) Institute of Clinical Physiology (IFC), 73100 Lecce, Italy
Interests: Mediterranean diet; nutraceuticals and functional food; polyphenols; unsaturated fatty acids; nutrigenomics; gene expression; cell signaling; molecular targets; inflammation; atherosclerosis; angiogenesis; cardiometabolic diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Egeria Scoditti

E-Mail Website
Guest Editor
National Research Council, Institute of Clinical Physiology, Lecce Section, Laboratory of Vascular Biology and Nutrigenomics, Ecotekne Campus, Via Monteroni, 73100 Lecce, Italy
Interests: nutrition; signaling pathways; chronic disease; genomics; cardiometabolic diseases; inflammation; oxidative stress; miRNAs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The gut microbiota, the most abundant microbial ecosystem living in the human body, has emerged as a crucial regulator of host physiology, contributing to the maintenance of the structural and functional integrity of the intestinal epithelial barrier, the modulation of immune system development and function, antimicrobial protection, the metabolism of carbohydrates, lipids, and proteins, and the synthesis of several vitamins and neurotransmitters. The metabolic activity of intestinal bacteria, in particular, results in the production of several metabolites, including trimethylamine-N-oxide, secondary bile acids, short chain fatty acids, and aromatic amino acids, which exert regulatory functions at local and systemic levels in positive or negative ways. Alteration in the gut microbiota composition and/or function, termed dysbiosis, has been linked to the development and progression of cardiometabolic diseases, which are the number-one cause of death worldwide and encompass cardiovascular diseases, such as coronary heart disease, stroke, and hypertension, as well as metabolic diseases, such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease.

Diet plays a predominant role in modulating the composition and function of the gut microbiota. Dietary patterns, specific qualitative and quantitative nutrient combinations, and individual nutrients may influence bacterial growth and functional activity and also provide metabolic substrates of intestinal bacteria, leading to a decrease or contrarily an increase in the risk for cardiometabolic diseases, through pathways and mechanisms still largely unknown.

The aim of this Special Issue on “Dietary Patterns, Gut Microbiome, and Cardiometabolic Diseases” is to provide a comprehensive summary of current original research and review articles highlighting the critical role of dietary patterns, including foods rich in dietary fiber and bioactive compounds, in improving the wellness of the intestinal ecosystem and preventing cardiometabolic dysfunctions.

We sincerely hope that this Special Issue will advance our understanding of how dietary patterns and individual nutrients exert beneficial effects on gut microbiome crosstalk and related molecular mechanisms with the aim to identify new effective and safety dietary strategies in the prevention and treatment of cardiometabolic diseases.

Dr. Maria Annunziata Carluccio
Dr. Egeria Scoditti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • gut microbiota
  • cardiometabolic disease
  • nutrients
  • inflammation
  • immune response
  • bioactive compounds
  • healthy dietary pattern
  • dysbiosis

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

20 pages, 3618 KiB  
Article
Polyphenols and Cardiometabolic Health: Knowledge and Concern among Romanian People
by Ioana Mariana Haș, Bernadette-Emőke Teleky, Dan-Cristian Vodnar, Bianca Eugenia Ștefănescu, Delia Mirela Tit and Maria Nițescu
Nutrients 2023, 15(10), 2281; https://doi.org/10.3390/nu15102281 - 12 May 2023
Cited by 5 | Viewed by 2362
Abstract
The cardiometabolic health of the population is a crucial indicator of public health, considering the significant impact of cardiovascular disease (CVD) and diabetes on global mortality. Determining the population’s knowledge and the predictors of these pathologies is essential in developing effective educational and [...] Read more.
The cardiometabolic health of the population is a crucial indicator of public health, considering the significant impact of cardiovascular disease (CVD) and diabetes on global mortality. Determining the population’s knowledge and the predictors of these pathologies is essential in developing effective educational and clinical strategies for the prevention and management of cardiometabolic risk (CMR). Polyphenols are natural compounds with a multitude of beneficial effects on cardiometabolic health. This study explored the current knowledge, understanding, and awareness of CMR, the benefits of polyphenols among Romanians, and how sociodemographic and clinical characteristics influence this aspect. Five hundred forty-six subjects responded anonymously to an online questionnaire designed to assess their knowledge. The data were collected and analyzed based on gender, age, education level, and BMI status. Most respondents expressed concern to a great or very great extent about their health (78%) and food (60%), with significant differences (p < 0.05) depending on age, educational level, and BMI status. Of the respondents, 64.8% declared that they were familiar with the CMR term. Still, the results showed a weak correlation between the stated risk factors and the self-assessment of increased risk (r = 0.027) for CVD or diabetes. Only 35% of the respondents reported a good or very good knowledge of the term “polyphenols”, 86% recognized the antioxidant effect, and significantly fewer (26%) recognized the prebiotic effect. Developing and implementing targeted educational strategies to enhance learning and individual behaviors related to CMR factors and the benefits of polyphenols is necessary. Full article
(This article belongs to the Special Issue Dietary Patterns, Gut Microbiome and Cardiometabolic Diseases)
►▼ Show Figures

Figure 1

15 pages, 2130 KiB  
Article
Diet Quality, Microbial Lignan Metabolites, and Cardiometabolic Health among US Adults
by Nicholas A. Koemel, Alistair M. Senior, Tarik Benmarhnia, Andrew Holmes, Mirei Okada, Youssef Oulhote, Helen M. Parker, Sanam Shah, Stephen J. Simpson, David Raubenheimer, Timothy P. Gill, Nasser Laouali and Michael R. Skilton
Nutrients 2023, 15(6), 1412; https://doi.org/10.3390/nu15061412 - 15 Mar 2023
Cited by 2 | Viewed by 2406
Abstract
The gut microbiome has been shown to play a role in the relationship between diet and cardiometabolic health. We sought to examine the degree to which key microbial lignan metabolites are involved in the relationship between diet quality and cardiometabolic health using a [...] Read more.
The gut microbiome has been shown to play a role in the relationship between diet and cardiometabolic health. We sought to examine the degree to which key microbial lignan metabolites are involved in the relationship between diet quality and cardiometabolic health using a multidimensional framework. This analysis was undertaken using cross-sectional data from 4685 US adults (age 43.6 ± 16.5 years; 50.4% female) participating in the National Health and Nutrition Examination Survey for 1999–2010. Dietary data were collected from one to two separate 24-hour dietary recalls and diet quality was characterized using the 2015 Healthy Eating Index. Cardiometabolic health markers included blood lipid profile, glycemic control, adiposity, and blood pressure. Microbial lignan metabolites considered were urinary concentrations of enterolignans, including enterolactone and enterodiol, with higher levels indicating a healthier gut microbial environment. Models were visually examined using a multidimensional approach and statistically analyzed using three-dimensional generalized additive models. There was a significant interactive association between diet quality and microbial lignan metabolites for triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, oral glucose tolerance, adiposity, systolic blood pressure, and diastolic blood pressure (all p < 0.05). Each of these cardiometabolic health markers displayed an association such that optimal cardiometabolic health was only observed in individuals with both high diet quality and elevated urinary enterolignans. When comparing effect sizes on the multidimensional response surfaces and model selection criteria, the strongest support for a potential moderating relationship of the gut microbiome was observed for fasting triglycerides and oral glucose tolerance. In this study, we revealed interactive associations of diet quality and microbial lignan metabolites with cardiometabolic health markers. These findings suggest that the overall association of diet quality on cardiometabolic health may be affected by the gut microbiome. Full article
(This article belongs to the Special Issue Dietary Patterns, Gut Microbiome and Cardiometabolic Diseases)
►▼ Show Figures

Graphical abstract

14 pages, 3627 KiB  
Article
Sodium Alginate Prevents Non-Alcoholic Fatty Liver Disease by Modulating the Gut–Liver Axis in High-Fat Diet-Fed Rats
by Hui Zhao, Xiang Gao, Zhizuo Liu, Lei Zhang, Xuan Fang, Jianping Sun, Zhaofeng Zhang and Yongye Sun
Nutrients 2022, 14(22), 4846; https://doi.org/10.3390/nu14224846 - 16 Nov 2022
Cited by 16 | Viewed by 2512
Abstract
Previous studies have suggested that the sodium alginate (SA) is beneficial for the treatment of non-alcoholic fatty liver disease (NAFLD), while the potential mechanisms are largely unknown. The present study aimed to clarify the effects and potential mechanisms of SA in preventing NAFLD [...] Read more.
Previous studies have suggested that the sodium alginate (SA) is beneficial for the treatment of non-alcoholic fatty liver disease (NAFLD), while the potential mechanisms are largely unknown. The present study aimed to clarify the effects and potential mechanisms of SA in preventing NAFLD via the gut−liver axis. Thirty-two male Sprague−Dawley rats were randomly divided into four groups: normal control group (NC); high-fat diet group (HFD); HFD with 50 mg/kg/d sodium alginate group (LSA); HFD with 150 mg/kg/d sodium alginate group (HSA). After 16 weeks, the rats were scarified to collect blood and tissues. The results indicated that SA significantly reduced their body weight, hepatic steatosis, serum triglyceride (TG), alanine transaminase (ALT) and tumor necrosis factor α (TNF-α) levels and increased serum high-density lipoprotein-cholesterol (HDL-C) levels in comparison with HFD group (p < 0.05). The elevated mRNA and protein expression of genes related to the toll-like receptor 4 (TLR-4)/nuclear factor-kappa B (NF-κB)/nod-like receptor protein 3 (NLRP3) inflammatory signaling pathway in the liver of HFD-fed rats was notably suppressed by SA. In terms of the gut microbiota, the LSA group showed a significantly higher fecal abundance of Oscillospiraceae_UCG_005, Butyricicoccaceae_UCG_009 and Colidextribacter compared with the HFD group (p < 0.05). The rats in the HSA group had a higher abundance of unclassified_Lachnospiraceae, Colidextribacter and Oscillibacter compared with the HFD-associated gut community (p < 0.05). In addition, rats treated with SA showed a significant increase in fecal short chain fatty acids (SCFAs) levels and a decline in serum lipopolysaccharide (LPS) levels compared with the HFD group (p < 0.05). Moreover, the modulated bacteria and microbial metabolites were notably correlated with the amelioration of NAFLD-related indices and activation of the hepatic TLR4/NF-κB/NLRP3 pathway. In conclusion, SA prevented NAFLD and the potential mechanism was related to the modulation of the gut–liver axis. Full article
(This article belongs to the Special Issue Dietary Patterns, Gut Microbiome and Cardiometabolic Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop