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Nutrients
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Nutrition and Diet on the Prevention and Management of Cancer...
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Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 5 July 2024 | Viewed by 12467

Special Issue Editors

Dr. Tung-Sung Tseng

E-Mail Website
Guest Editor
Behavioral and Community Health Sciences, LSUHSC School of Public, New Orleans, LA 70112, USA
Interests: cancer; obesity; sugar-sweetened beverage; behavioral intervention; smoking; health disparities
Special Issues, Collections and Topics in MDPI journals
Dr. Liwei Chen

E-Mail Website
Guest Editor
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E. Young Drive, Los Angeles, CA 90095, USA
Interests: nutrition; dietary patterns; sugar-sweetened beverage; physical activity; health disparities; cardiometabolic diseases

Special Issue Information

Dear Colleagues,

Cancer and other chronic diseases are the leading causes of death. These multifactorial diseases are developed due to a long-term disturbance to the biology, behavioral, as well as environments. Poor nutrition/diet (e.g., measured by dietary micronutrients, macronutrients, food groups, or overall patterns) are common and major determinants in the development of most cancer and chronic disease. In addition, poor diet is also highly correlated with low SES and other unhealthy behaviors, such as smoking, alcohol drinking, and physical inactivity.  

In this Special Issue, “Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Disease”, we will present state-of-the-art approaches in dietary/nutrition, which aim to better understand the cause of nutrition-related diseases, their consequences, and prognosis. There will be a particular focus on the role of diet/nutrition on cancer and chronic disease, their interplay with biological factors, health/risk behaviors, and social determinants of health factors. Nutrition and dietary factors including dietary patents, micronutrients, antioxidants, dietary intervention, innovation approaches, or new technology applications are highly welcome topics in this issue. Original articles or short communications that advance current knowledge on the role of nutrition and diet on cancer and chronic disease are also welcome. We will also accept protocol, narrative reviews and systematic reviews or meta-analyses.

We look forward to your contributions.

Dr. Tung-Sung Tseng
Dr. Liwei Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • obesity
  • diabetes
  • CVD
  • Alzheimer's disease
  • vitamins and minerals
  • antioxidants
  • macronutrients
  • dietary pattern
  • eating timing
  • food groups
  • eating behavior
  • dietary intervention

Published Papers (6 papers)

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Research

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17 pages, 3302 KiB  
Article
Inhibitory Effects of Urolithins, Bioactive Gut Metabolites from Natural Polyphenols, against Glioblastoma Progression
by Ching-Kai Shen, Bor-Ren Huang, Vichuda Charoensaensuk, Liang-Yo Yang, Cheng-Fang Tsai, Yu-Shu Liu, Sheng-Wei Lai, Dah-Yuu Lu, Wei-Lan Yeh and Chingju Lin
Nutrients 2023, 15(23), 4854; https://doi.org/10.3390/nu15234854 - 21 Nov 2023
Viewed by 1152
Abstract
We previously reported that proinflammatory cytokines, particularly tumor necrosis factor (TNF)-α, promoted tumor migration, invasion, and proliferation, thus worsening the prognosis of glioblastoma (GBM). Urolithins, the potent metabolites produced by the gut from pomegranate polyphenols, have anticancer properties. To develop an effective therapy [...] Read more.
We previously reported that proinflammatory cytokines, particularly tumor necrosis factor (TNF)-α, promoted tumor migration, invasion, and proliferation, thus worsening the prognosis of glioblastoma (GBM). Urolithins, the potent metabolites produced by the gut from pomegranate polyphenols, have anticancer properties. To develop an effective therapy for GBM, this study aimed to study the effects of urolithins against GBM. Urolithin A and B significantly reduced GBM migration, reduced epithelial–mesenchymal transition, and inhibited tumor growth. Moreover, urolithin A and B inhibited TNF-α-induced vascular cell adhesion molecule (VCAM)-1 and programmed death ligand 1 (PD-L1) expression, thereby reducing human monocyte (HM) binding to GBM cells. Aryl hydrocarbon receptor (AhR) level had higher expression in patients with glioma than in healthy individuals. Urolithins are considered pharmacological antagonists of AhR. We demonstrated that the inhibition of AhR reduced TNF-α-stimulated VCAM-1 and PD-L1 expression. Furthermore, human macrophage condition medium enhanced expression of PD-L1 in human GBM cells. Administration of the AhR antagonist attenuated the enhancement of PD-L1, indicating the AhR modulation in GBM progression. The modulatory effects of urolithins in GBM involve inhibiting the Akt and epidermal growth factor receptor pathways. The present study suggests that urolithins can inhibit GBM progression and provide valuable information for anti-GBM strategy. Full article
(This article belongs to the Special Issue Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Diseases)
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15 pages, 1630 KiB  
Article
Association between Gut Microbiota and Breast Cancer: Diet as a Potential Modulating Factor
by Duygu Altinok Dindar, Brie Chun, Amy Palma, John Cheney, Madeline Krieger, Kristin Kasschau, Keaton Stagaman, Zahi I. Mitri, Shaun M. Goodyear, Jackilen Shannon, Lisa Karstens, Thomas Sharpton and Zhenzhen Zhang
Nutrients 2023, 15(21), 4628; https://doi.org/10.3390/nu15214628 - 31 Oct 2023
Cited by 1 | Viewed by 2051
Abstract
Breast cancer (BCa) has many well-known risk factors, including age, genetics, lifestyle, and diet; however, the influence of the gut microbiome on BCa remains an emerging area of investigation. This study explores the connection between the gut microbiome, dietary habits, and BCa risk. [...] Read more.
Breast cancer (BCa) has many well-known risk factors, including age, genetics, lifestyle, and diet; however, the influence of the gut microbiome on BCa remains an emerging area of investigation. This study explores the connection between the gut microbiome, dietary habits, and BCa risk. We enrolled newly diagnosed BCa patients and age-matched cancer-free controls in a case-control study. Comprehensive patient data was collected, including dietary habits assessed through the National Cancer Institute Diet History Questionnaire (DHQ). 16S rRNA amplicon sequencing was used to analyze gut microbiome composition and assess alpha and beta diversity. Microbiome analysis revealed differences in the gut microbiome composition between cases and controls, with reduced microbial diversity in BCa patients. The abundance of three specific microbial genera—Acidaminococus, Tyzzerella, and Hungatella—was enriched in the fecal samples taken from BCa patients. These genera were associated with distinct dietary patterns, revealing significant associations between the presence of these genera in the microbiome and specific HEI2015 components, such as vegetables and dairy for Hungatella, and whole fruits for Acidaminococus. Demographic characteristics were well-balanced between groups, with a significantly higher body mass index and lower physical activity observed in cases, underscoring the role of weight management in BCa risk. Associations between significant microbial genera identified from BCa cases and dietary intakes were identified, which highlights the potential of the gut microbiome as a source of biomarkers for BCa risk assessment. This study calls attention to the complex interplay between the gut microbiome, lifestyle factors including diet, and BCa risk. Full article
(This article belongs to the Special Issue Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Diseases)
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12 pages, 581 KiB  
Article
Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men
by Hui-Yi Lin, Xiaodan Zhu, Alise J. Aucoin, Qiufan Fu, Jong Y. Park and Tung-Sung Tseng
Nutrients 2023, 15(15), 3298; https://doi.org/10.3390/nu15153298 - 25 Jul 2023
Viewed by 1187
Abstract
High prostate-specific antigen (PSA) levels can indicate potential prostate problems and are a warning sign of prostate cancer. The impact of antioxidants on the PSA of generally healthy men is understudied. This study aims to evaluate 14 dietary and endogenous antioxidants associated with [...] Read more.
High prostate-specific antigen (PSA) levels can indicate potential prostate problems and are a warning sign of prostate cancer. The impact of antioxidants on the PSA of generally healthy men is understudied. This study aims to evaluate 14 dietary and endogenous antioxidants associated with PSA levels for United States (US) men. We assessed 7398 men using the 2003–2010 US population-based National Health and Nutrition Examination Survey (NHANES). The PSA levels were categorized into three groups: Normal, borderline, and elevated levels. We performed analyses for middle-aged and older groups aged 40–64.9 and ≥65, respectively. The weighted multinomial regressions were performed to evaluate antioxidants associated with the PSA status. For results, 0.3% and 3.4% of middle-aged and older men, respectively, had elevated PSA (>10 ng/mL). Men with a higher serum albumin level had a lower risk of an elevated PSA, adjusting for age. The magnitude of albumin’s impact on PSA is larger in middle-aged men than in older men (OR of elevated PSA = 0.82 and 0.90, respectively, interaction p = 0.002). Other antioxidants are not associated with PSA. Our findings support men with low serum albumin tend to have an elevated PSA level, so related interventions can be considered to decrease PSA for maintaining prostate health. Full article
(This article belongs to the Special Issue Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Diseases)
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15 pages, 667 KiB  
Article
Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
by Wei-Ting Lin, Gabrielle V. Gonzalez, Yu-Hsiang Kao, Hui-Yi Lin, Mirandy S. Li, David W. Seal, Chien-Hung Lee, Chih-yang Hu, Lei-Shih Chen and Tung-Sung Tseng
Nutrients 2023, 15(15), 3291; https://doi.org/10.3390/nu15153291 - 25 Jul 2023
Cited by 2 | Viewed by 963
Abstract
Body mass index (BMI) as well as sugar-sweetened beverages (SSB) has been suggested to independently decrease 25-hydroxyvitamin D (25(OH)D). However, the relationship between SSB, BMI, and 25(OH)D is uncertain. This study aimed to investigate the potential mediating role of BMI in the association [...] Read more.
Body mass index (BMI) as well as sugar-sweetened beverages (SSB) has been suggested to independently decrease 25-hydroxyvitamin D (25(OH)D). However, the relationship between SSB, BMI, and 25(OH)D is uncertain. This study aimed to investigate the potential mediating role of BMI in the association between SSB intake and 25(OH)D. A total of 4505 representative U.S. adults aged above 20 years and without liver conditions were selected from the 2013–2014 NHANES. All analyses were performed under survey modules with appropriate sampling weights. The prevalence of 25(OH)D insufficiency and deficiency was 37.8% and 24.1% in U.S. adults, respectively. Compared with non-SSB consumers, an increased risk of vitamin D deficiency was found in either heavy SSB consumers or soda consumers, respectively (aOR = 2.10, 95% CI = 1.25–3.54 in heavy SSB consumers; aOR = 1.61, 95% CI = 1.06–2.44 in soda consumers). Around 21.3% of the total effect of sugar intake from SSB on decreased 25(OH)D was explained by BMI. In conclusion, high total sugar intake from SSB and BMI independently contribute to lower 25(OH)D, and BMI mediates the inverse association between total sugar intake from SSB intake and 25(OH)D. Furthermore, an increased risk of having vitamin D deficiency was found in the population who consumed higher levels of sugar from SSB or soda drinks. Full article
(This article belongs to the Special Issue Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Diseases)
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Review

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14 pages, 1002 KiB  
Review
The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
by Aleksandra Kapała, Małgorzata Szlendak and Emilia Motacka
Nutrients 2022, 14(23), 5152; https://doi.org/10.3390/nu14235152 - 03 Dec 2022
Cited by 15 | Viewed by 5390
Abstract
Lycopene is a nutraceutical with health-promoting and anti-cancer activities, but due to a lack of evidence, there are no recommendations regarding its use and dosage. This review aimed to evaluate the benefits of lycopene supplementation in cancer prevention and treatment based on the [...] Read more.
Lycopene is a nutraceutical with health-promoting and anti-cancer activities, but due to a lack of evidence, there are no recommendations regarding its use and dosage. This review aimed to evaluate the benefits of lycopene supplementation in cancer prevention and treatment based on the results of in vivo studies. We identified 72 human and animal studies that were then analysed for endpoints such as cancer incidence, improvement in treatment outcomes, and the mechanisms of lycopene action. We concluded that the results of most of the reviewed in vivo studies confirmed the anti-cancer activities of lycopene. Most of the studies concerned prostate cancer, reflecting the number of in vitro studies. The reported mechanisms of lycopene action in vivo included regulation of oxidative and inflammatory processes, induction of apoptosis, and inhibition of cell division, angiogenesis, and metastasis formation. The predominance of particular mechanisms seemed to depend on tumour organ localisation and the local storage capacity of lycopene. Finally, there is a need to look for predictive factors to identify a population that may benefit from lycopene supplementation. The potential candidates appear to be race, single nucleotide polymorphisms in carotene-cleaving enzymes, some genetic abbreviations, and insulin-like growth factor-dependent and inflammatory diseases. Full article
(This article belongs to the Special Issue Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Diseases)
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Other

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12 pages, 2713 KiB  
Systematic Review
Malnutrition as a Risk Factor in the Development of Oral Cancer: A Systematic Literature Review and Meta-Analyses
by Romeo Patini, Eleonora Favetti Giaquinto, Gioele Gioco, Raffaella Castagnola, Vittoria Perrotti, Cosimo Rupe, Leonardo Di Gennaro, Giuseppina Nocca and Carlo Lajolo
Nutrients 2024, 16(3), 360; https://doi.org/10.3390/nu16030360 - 26 Jan 2024
Viewed by 986
Abstract
This systematic review and meta-analyses aimed to assess whether malnutrition may increase the incidence of oral cancer. Following the PRISMA statement, the research was conducted on PubMed, Scopus, and MEDLINE via OVID without any time restrictions. The risk of bias was assessed, and [...] Read more.
This systematic review and meta-analyses aimed to assess whether malnutrition may increase the incidence of oral cancer. Following the PRISMA statement, the research was conducted on PubMed, Scopus, and MEDLINE via OVID without any time restrictions. The risk of bias was assessed, and the quality of evidence for each performed meta-analysis was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Sixty-one articles met the inclusion criteria and seven studies underwent quantitative evaluation. For our meta-analysis on hypovitaminosis B, three studies with a total of 90,011 patients were included. An odds ratio of 2.22 was found. Our meta-analysis on the correlation between vitamin C and oral cancer included one study with a total of 866 patients and the derived odds ratio was 1.06. Our meta-analysis on the relationship between vitamin D deficiency and the incidence of oral cancer included three studies with a total of 12,087 patients and the odds ratio was −2.58. The GRADE system showed a moderate strength of evidence due to the presence of studies with a high risk of bias and high indirectness of the data given. The present findings suggest that an inadequate intake of vitamins, particularly vitamin D, poses a risk for the onset of oral cancer. Full article
(This article belongs to the Special Issue Nutrition and Diet on the Prevention and Management of Cancer and Other Chronic Diseases)
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