Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Questionnaires
2.3. Dietary Intake
2.4. SSB Intake
2.5. Body Mass Index
2.6. Clinical Examination
2.7. Statistical Analysis
3. Results
4. Discussion
5. Limitation and Strengths
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Factors | 25-Hydroxyvitamin D (ng/mL) | |||||
---|---|---|---|---|---|---|
Mean ± se | p-Value | Normal | Insufficiency | Deficiency | p-Value | |
Number of population 1 | N = 4505 | N = 1465 | N = 1687 | N = 1353 | ||
Survey-weighted 2 | 28.0 ± 0.5 | 38.1% | 37.8% | 24.1% | ||
Personal characteristics | ||||||
Age, years (mean ± se) | -- | -- | 52.5 ± 0.7 | 44.9 ± 0.5 | 41.7 ± 0.9 | <0.001 |
Gender | <0.001 | <0.001 | ||||
Male | 26.6 ± 0.5 | 32.7% | 42.1% | 25.2% | ||
Female | 29.4 ± 0.6 | 43.3% | 33.6% | 23.1% | ||
Ethnicity | <0.001 | <0.001 | ||||
Non-Hispanic White | 30.7 ± 0.6 | 47.5% | 38.1% | 14.4% | ||
Non-Hispanic Black | 20.2 ± 0.6 | 15.4% | 26.0% | 58.6% | ||
Mexican American | 21.8 ± 1.0 | 14.9% | 42.4% | 42.7% | ||
Other Hispanic | 25.6 ± 0.6 | 25.0% | 50.4% | 24.6% | ||
Other Race | 24.9 ± 0.6 | 28.5% | 37.3% | 34.2% | ||
Ratio of family income to poverty | <0.001 | <0.001 | ||||
Below poverty | 23.9 ± 0.7 | 24.7% | 36.9% | 38.3% | ||
1–1.99 | 26.2 ± 0.6 | 31.0% | 39.4% | 29.5% | ||
2–2.99 | 27.5 ± 0.9 | 32.4% | 40.2% | 27.4% | ||
3–3.00 | 28.5 ± 0.8 | 41.1% | 37.9% | 21.0% | ||
≥4 | 30.6 ± 0.8 | 48.6% | 36.4% | 15.0% | ||
Lifestyle patterns | ||||||
Cigarette use | <0.001 | 0.002 | ||||
None | 28.1 ± 0.6 | 38.8% | 37.0% | 24.2% | ||
Former | 29.6 ± 0.5 | 41.7% | 40.3% | 18.0% | ||
Current | 25.6 ± 0.8 | 31.3% | 37.1% | 31.7% | ||
Alcohol use | 0.211 | 0.187 | ||||
None | 28.0 ± 0.7 | 35.4% | 26.5% | 28.1% | 0.187 | |
Light | 28.3 ± 0.7 | 39.9% | 37.6% | 22.5% | ||
Heavy | 27.0 ± 0.8 | 35.8% | 41.2% | 23.1% | ||
Physical activity (hour/week) | 0.002 | <0.001 | ||||
Low | 27.2 ± 0.4 | 35.0% | 37.6% | 27.3% | ||
Adequate | 29.3 ± 0.8 | 43.2% | 38.0% | 18.8% | ||
Medical conditions 3 | <0.001 | <0.001 | ||||
No | 25.9 ± 0.6 | 28.7% | 42.2% | 29.2% | ||
Yes | 29.7 ± 0.5 | 46.0% | 34.1% | 19.9% |
25-Hydroxyvitamin D (ng/mL) | ||||||
---|---|---|---|---|---|---|
Mean ± se | p-Value | Normal | Insufficiency | Deficiency | p-Value | |
Number of population 1 | N = 4505 | N = 1465 | N = 1687 | N = 1353 | ||
Survey-weighted 2 | 28.0 ± 0.5 | 38.1% | 37.8% | 24.1% | ||
Daily dietary intake, mean± se | ||||||
Total energy (kcal) | -- | -- | 2073 ± 19 | 2081 ± 37 | 2157 ± 34 | 0.136 |
Total sugar (g) | -- | -- | 106 ± 2.1 | 106 ± 2.0 | 114 ± 3.8 | 0.094 |
Total nutrients intake 3 | ||||||
Vitamin D (D2 + D3) (μg) | <0.001 | <0.001 | ||||
Sufficient | 34.8 ± 0.5 | 63.4% | 30.2% | 6.4% | ||
Insufficient | 25.1 ± 0.5 | 27.4% | 41.0% | 31.6% | ||
Calcium (mg) | <0.001 | <0.001 | ||||
Sufficient | 29.7 ± 0.6 | 45.3% | 36.3% | 18.4% | ||
Insufficient | 26.4 ± 0.5 | 31.6% | 39.1% | 29.3% | ||
SSB-related factors | ||||||
Sugar intake from SSB (g), mean ± se | -- | -- | 26.0 ± 2.9 | 36.1 ± 1.8 | 52.7 ± 3.7 | <0.001 |
Total sugar intake from SSB per day | <0.001 | <0.001 | ||||
Non-SSB consumers | 30.3 ± 0.6 | 47.1% | 35.7% | 17.1% | ||
<40 g | 28.1 ± 0.7 | 36.0% | 42.1% | 21.9% | ||
40–79 g | 25.9 ± 0.8 | 31.2% | 38.4% | 30.5% | ||
≥80 g | 23.7 ± 0.5 | 24.6% | 35.4% | 40.0% | ||
Type of soda consumption (n = 2742) | <0.001 | 0.002 | ||||
Non-soda SSB consumers 4 | 28.5 ± 0.7 | 38.8% | 37.8% | 23.3% | ||
Soda consumers 5 | 25.2 ± 0.6 | 28.0% | 40.0% | 32.1% | ||
Body mass index (kg/m2) | 0.003 | <0.001 | ||||
Normal/under weight | 29.9 ± 0.8 | 46.9% | 32.4% | 20.7% | ||
Overweight | 28.3 ± 0.6 | 38.7% | 40.4% | 20.9% | ||
Obesity | 26.1 ± 0.6 | 30.5% | 39.8% | 29.7% | ||
Clinical biomarker | ||||||
Alkaline phosphatase (IU/L) | 0.880 | 0.582 | ||||
Normal | 28.0 ± 0.5 | 38.1% | 37.9% | 24.0% | ||
Abnormal | 27.4 ± 3.9 | 39.1% | 26.6% | 34.3% | ||
Total triglycerides (mg/dL) | 0.123 | 0.379 | ||||
Normal | 28.2 ± 0.6 | 39.2% | 37.0% | 23.8% | ||
Higher | 27.6 ± 0.6 | 36.5% | 39.0% | 24.5% | ||
Phosphorus (mg/dL) | 0.230 | 0.682 | ||||
Normal | 27.8 ± 0.6 | 37.8% | 37.9% | 24.3% | ||
Abnormal | 29.5 ± 1.2 | 40.8% | 36.9% | 22.4% |
25-Hydroxyvitamin D Levels (ng/mL) | ||||
---|---|---|---|---|
Model 1 | Model 2 | |||
aDiff | (95%CI) | aDiff | (95%CI) | |
Total sugar intake from SSB | ||||
Non-SSB consumers | Ref | Ref | ||
<40 g | −1.07 | (−2.42, 0.27) | −1.02 | (−2.32, 0.28) |
40–79 g | −1.83 | (−3.23, −0.43) * | −1.42 | (−2.88, 0.03) |
≥80 g | −2.88 | (−4.33, −1.44) *** | −2.53 | (−3.93, −1.12) ** |
Body mass index (kg/m2) | ||||
Normal/under weight | -- | -- | Ref | |
Overweight | -- | -- | −1.58 | (−2.95, −0.21) * |
Obesity | -- | -- | −3.68 | (−4.77, −2.59) *** |
25-Hydroxyvitamin D Levels (ng/mL) | ||||
---|---|---|---|---|
Model 1 | Model 2 | |||
aDiff | (95%CI) | aDiff | (95%CI) | |
Type of SSB intake | ||||
Non-SSB consumers | Ref | Ref | ||
Non-soda SSB 1 | −0.50 | (−1.88, 0.88) | −0.33 | (−1.78, 1.11) |
Soda drinks 2 | −2.14 | (−3.37, −0.90) ** | −1.92 | (−3.14, −0.70) ** |
Body mass index (kg/m2) | ||||
Normal/under weight | -- | -- | Ref | |
Overweight | -- | -- | −1.60 | (−3.03, −0.16) * |
Obesity | -- | -- | −0.71 | (−4.84, −2.58) *** |
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Lin, W.-T.; Gonzalez, G.V.; Kao, Y.-H.; Lin, H.-Y.; Li, M.S.; Seal, D.W.; Lee, C.-H.; Hu, C.-y.; Chen, L.-S.; Tseng, T.-S. Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption. Nutrients 2023, 15, 3291. https://doi.org/10.3390/nu15153291
Lin W-T, Gonzalez GV, Kao Y-H, Lin H-Y, Li MS, Seal DW, Lee C-H, Hu C-y, Chen L-S, Tseng T-S. Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption. Nutrients. 2023; 15(15):3291. https://doi.org/10.3390/nu15153291
Chicago/Turabian StyleLin, Wei-Ting, Gabrielle V. Gonzalez, Yu-Hsiang Kao, Hui-Yi Lin, Mirandy S. Li, David W. Seal, Chien-Hung Lee, Chih-yang Hu, Lei-Shih Chen, and Tung-Sung Tseng. 2023. "Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption" Nutrients 15, no. 15: 3291. https://doi.org/10.3390/nu15153291