The Role of Nutraceuticals in Central Nervous System Disorders

Dear Colleagues,

Central nervous system (CNS) disorders span a wide range of ailments including neurodegenerative diseases and neuropsychological disorders, as well as neuronal injury subsequent to infection or trauma (e.g., traumatic brain injury). Although the underlying pathogenesis of any individual disorder may be unique, several common mechanisms appear to contribute to many of these conditions. In particular, oxidative stress, excitotoxicity, apoptosis, and (neuro)inflammation are significant contributing factors in the pathogenesis of multiple CNS disorders. Therefore, agents that are capable of mitigating one or more of these factors may be beneficial in slowing down the progression of neuronal cell dysfunction or death and, in turn, in reducing the clinical burden for patients afflicted by these disorders. “Nutraceuticals” is a term commonly used to describe natural products derived from foods that possess significant biological activity leading to therapeutic benefits. Nutraceuticals such as polyphenols are well-known but these natural products are found in many chemical variations. For the current Special Issue, we seek the submission of articles focused on the interrogation of nutraceuticals as potential therapeutics for diverse CNS disorders. We are particularly interested in mechanistic studies performed in cell culture systems, invertebrates, or rodents, as well as investigations conducted in preclinical disease models. The overarching goals of this Special Issue are to highlight the potential utility of nutraceuticals in treating CNS disorders and to identify gaps in this field of inquiry which may stimulate future research.

Prof. Dr. Daniel Linseman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutraceuticals is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• nutraceuticals
• natural products
• polyphenols
• antioxidants
• anti-inflammatory
• anti-apoptotic
• neurodegeneration
• Alzheimer’s
• Parkinson's disease
• amyotrophic lateral sclerosis