Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.8
3.0
Journals
Neurology International
Special Issues
Towards an All-Inclusive Paradigm for Acute Stroke Treatment—Challenges and Innovations
share announcement

Towards an All-Inclusive Paradigm for Acute Stroke Treatment—Challenges and Innovations

A special issue of Neurology International (ISSN 2035-8377). This special issue belongs to the section "Movement Disorders and Neurodegenerative Diseases".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 2144

Special Issue Editors

Dr. Riwaj Bhagat

E-Mail Website
Guest Editor
Conemaugh Memorial Medical Center, Johnstown, PA 15905, USA
Interests: general neurology; vascular neurology
Dr. Ekokobe Fonkem

E-Mail Website
Guest Editor
1. Baylor Scott and White Health System Neuro-Oncology Program, 3410 Worth Street, Suite 820, Dallas, TX 75246, USA
2. Surgery at the Texas A&M University Health Science Center, 8441 Riverside Pkwy, Clinical Building 1, Suite 3100, Bryan, TX 77807, USA
Interests: neuro oncology; neurology; wellbeing of brain tumour patients

Special Issue Information

Dear Colleagues,

Stroke remains a leading cause of long-term disability and mortality worldwide, and, in recent years, remarkable advancements have transformed the landscape of acute stroke care.

This Special Issue aims to provide a comprehensive platform for innovative research and clinical perspectives that are reshaping the management of acute stroke. Key areas of focus include diagnostic innovations—such as novel imaging techniques, biomarker discovery for early stroke detection, and the deployment of mobile stroke units—which underscore the urgency of time-sensitive intervention. Therapeutic progress, including expanded time windows for intravenous thrombolysis and mechanical thrombectomy, continues to enhance patient outcomes. Additionally, emerging neuroprotective strategies hold promise in preserving neural function and improving recovery. This Special Issue also seeks to explore the integration of telemedicine, particularly tele-stroke services, in expanding access to underserved regions. The application of artificial intelligence and machine learning for stroke detection, triage, and outcome prediction represents a paradigm shift in personalized care.

We welcome original research articles, systematic reviews, and clinical perspectives that address innovations, challenges, and solutions across these domains. Contributions highlighting health equity, global disparities, and the implementation of cutting-edge technologies are especially encouraged. By fostering dialogue across disciplines, this Special Issue aspires to contribute impactful insights toward an inclusive and forward-thinking framework for acute stroke treatment.

Dr. Riwaj Bhagat
Dr. Ekokobe Fonkem
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neurology International is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • thrombolytic therapy
  • mechanical thrombectomy
  • telestroke
  • artificial intelligence
  • neuroprotection

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1562 KB  
Article
Association Between Carotid Artery Small Plaque on Computed Tomography Angiography and Embolic Stroke of Undetermined Source
by Junpei Nagasawa, Tatsuhiro Yokoyama, Makiko Ogawa, Ryuichi Okamoto, Mari Shibukawa, Junya Ebina, Takehisa Hirayama and Osamu Kano
Neurol. Int. 2025, 17(9), 148; https://doi.org/10.3390/neurolint17090148 - 14 Sep 2025
Viewed by 195
Abstract
Objectives: While traditionally, carotid plaques with significant stenosis have been considered major embolic sources, recent evidence suggests that even non-stenotic small plaques with a <50% stenosis rate may contribute to cerebral infarction. Herein, we evaluated the relationship between non-stenotic small plaques and [...] Read more.
Objectives: While traditionally, carotid plaques with significant stenosis have been considered major embolic sources, recent evidence suggests that even non-stenotic small plaques with a <50% stenosis rate may contribute to cerebral infarction. Herein, we evaluated the relationship between non-stenotic small plaques and embolic stroke of undetermined source (ESUS) using computed tomography angiography (CTA). Materials and Methods: We retrospectively reviewed our single-institutional database of hospitalized patients with stroke between April 2017 and December 2022 and enrolled them with ESUS. We evaluated the presence or absence of non-stenotic carotid artery plaque lesions ipsilateral and contralateral to the cerebral infarction lesion using CTA. A neurologist, blinded to the stroke side and all other clinical information, reviewed each CTA and viewed the axial and sagittal CTA source images. In each image, a line perpendicular to the vessel wall was drawn and the plaque diameter was measured. The largest part was considered as the maximum plaque diameter. Results: A total of 951 patients with stroke were hospitalized during the study period. Among these, 35 patients with unilateral anterior circulation ESUS were enrolled. Plaque prevalence > 3 mm was compared between the carotid artery on the ESUS side and contralateral carotid artery. The prevalences were 31% and 8% on the ESUS and contralateral sides, respectively. Plaques > 3 mm were often found on the ESUS side. Conclusions: Patients with ESUS were more likely to exhibit non-stenotic plaques of ≥3 mm in the infarcted carotid artery than in the contralateral carotid artery. Thus, small non-stenotic plaques may be the embolization source in ESUS, and CT angiography is useful for these evaluations. Full article
(This article belongs to the Special Issue Towards an All-Inclusive Paradigm for Acute Stroke Treatment—Challenges and Innovations)
►▼ Show Figures

Figure 1

13 pages, 1495 KB  
Article
Exploring Left Atrial Appendage Thrombi in Large Vessel Occlusion Stroke by Cardiac CT: Thrombus Features, LAA Characteristics and the Impact of Direct Oral Anticoagulation
by Karim Mostafa, Sarah Krutmann, Cosima Wünsche, Naomi Larsen, Alexander Seiler, Hatim Seoudy, Domagoj Schunk, Olav Jansen and Patrick Langguth
Neurol. Int. 2025, 17(8), 127; https://doi.org/10.3390/neurolint17080127 - 11 Aug 2025
Viewed by 401
Abstract
Background: Large vessel occlusion (LVO) strokes account for a significant proportion of ischemic strokes and are often cardioembolic in origin, particularly following atrial fibrillation (AF) with thrombus formation in the left atrial appendage (LAA). Although direct oral anticoagulation (DOAC) therapy reduces stroke risk [...] Read more.
Background: Large vessel occlusion (LVO) strokes account for a significant proportion of ischemic strokes and are often cardioembolic in origin, particularly following atrial fibrillation (AF) with thrombus formation in the left atrial appendage (LAA). Although direct oral anticoagulation (DOAC) therapy reduces stroke risk in AF, anatomical and flow-related factors may still allow thrombi to form and persist, revealing the limitations of anticoagulation in high-risk patients. Examining structural and hemodynamic factors contributing to thrombus persistence is essential for optimizing patient management. Methods: We retrospectively analyzed 169 AF patients with LVO stroke who underwent cardiac CT (cCT) during acute stroke assessment. Patients were categorized based on the presence or absence of persistent LAA thrombi and further stratified by DOAC status. LAA volume, blood stasis and left ventricular (LV) diameter were measured. Thrombi were assessed using Hounsfield Unit (HU) analysis to evaluate potential differences in thrombus composition. Logistic regression analysis was performed to identify independent predictors of thrombus persistence with adjustment for DOAC therapy. Results: Persistent LAA thrombi were identified in 23 patients (13.6%). Patients with thrombi had significantly higher rates of stasis (p = 0.004), larger left ventricular diameters (p = 0.0019) and higher LAA volumes (p = 0.004). When adjusted for DOAC therapy, larger LAA volume (OR 1.05, p = 0.011), presence of LAA stasis (OR 6.14, p = 0.013) and increased LV diameter (OR 1.06, p = 0.006) were independent predictors of thrombus persistence. Thrombus size and HU values did not differ significantly between DOAC and non-DOAC groups. Notably, 30.4% of patients with persistent thrombi were on adequate DOAC therapy. Conclusions: LAA volume, stasis and LV enlargement predict thrombus persistence in the LAA of AF patients with LVO stroke, even under adequate DOAC therapy. These findings highlight the potential need for alternative antithrombotic strategies, including interventional LAA occlusion, and warrant further investigation into individualized stroke prevention in high-risk AF populations. Full article
(This article belongs to the Special Issue Towards an All-Inclusive Paradigm for Acute Stroke Treatment—Challenges and Innovations)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop