Special Issue "Nanomaterials and Additive Manufacturing towards the Design of Advanced Scaffolds for Hard Tissue Regeneration"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editors

Guest Editor
Prof. Dr. Antonio Gloria

Institute of Polymers, Composites and Biomaterials - National Research Council of Italy, V.le J. F. Kennedy 54 – Mostra d’Oltremare PAD. 20, 80125 Naples, Italy
Website | E-Mail
Phone: +390812425942
Interests: design for additive manufacturing; reverse engineering; CAD; FEA; nanomaterials; scaffolds
Guest Editor
Prof. Dr. Massimo Martorelli

Department of Industrial Engineering, Fraunhofer JL IDEAS – University of Naples “Federico II”, P.le Tecchio 80, 80125 Naples, Italy
Website | E-Mail
Interests: design for additive Manufacturing; reverse engineering; CAD; FEA; nanomaterials; scaffolds

Special Issue Information

Dear Colleagues,

In the field of tissue engineering, the synergistic combination of cells and 3D porous scaffolds is fundamental. It is frequently reported that a scaffold should possess an interconnected pore network to support cell adhesion, proliferation and differentiation. Over the past years, many efforts have been made to design advanced scaffolds with improved properties for tissue regeneration.

In this context, unlike conventional technologies, additive manufacturing allows the fabrication of scaffolds with complex shapes, reproducible architecture, tailored mechanical and mass transport properties.

On the other hand, benefiting from the nanotechnology approach, nanomaterials and nanostructures have been widely developed and analyzed. As an effect of novel physical properties related to the nanoscale features, nanomaterials generally have more interesting properties if compared to their microstructured counterparts.

Nanoscale features play a crucial role in scaffold function and nanocomposites consisting of a polymer matrix reinforced with inorganic nanoparticles should better mimic the structure of hard tissues (i.e., bone).

Accordingly, it is through the combination of nanomaterials and additive manufacturing that the present Special Issue of Nanomaterials is aimed at presenting the current advances in the design of scaffolds for hard tissue regeneration.

For this reason, in the present Special Issue we invite contributions from leading groups in the field with the aim of providing a complete view of the current progresses.

Prof. Dr. Antonio Gloria
Prof. Dr. Massimo Martorelli
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • additive Manufacturing
  • nanomaterials
  • scaffolds
  • hard Tissues
  • design for Additive Manufacturing
  • image Analysis
  • finite Element Analysis

Published Papers (2 papers)

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Review

Open AccessReview Reconstructing Bone with Natural Bone Graft: A Review of In Vivo Studies in Bone Defect Animal Model
Nanomaterials 2018, 8(12), 999; https://doi.org/10.3390/nano8120999
Received: 27 October 2018 / Revised: 25 November 2018 / Accepted: 29 November 2018 / Published: 3 December 2018
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Abstract
Bone defects caused by fracture, disease or congenital defect remains a medically important problem to be solved. Bone tissue engineering (BTE) is a promising approach by providing scaffolds to guide and support the treatment of bone defects. However, the autologous bone graft has [...] Read more.
Bone defects caused by fracture, disease or congenital defect remains a medically important problem to be solved. Bone tissue engineering (BTE) is a promising approach by providing scaffolds to guide and support the treatment of bone defects. However, the autologous bone graft has many defects such as limited sources and long surgical procedures. Therefore, xenograft bone graft is considered as one of the best substitutions and has been effectively used in clinical practice. Due to better preserved natural bone structure, suitable mechanical properties, low immunogenicity, good osteoinductivity and osteoconductivity in natural bone graft, decellularized and demineralized bone matrix (DBM) scaffolds were selected and discussed in the present review. In vivo animal models provide a complex physiological environment for understanding and evaluating material properties and provide important reference data for clinical trials. The purpose of this review is to outline the in vivo bone regeneration and remodeling capabilities of decellularized and DBM scaffolds in bone defect models to better evaluate the potential of these two types of scaffolds in BTE. Taking into account the limitations of the state-of-the-art technology, the results of the animal bone defect model also provide important information for future design of natural bone composite scaffolds. Full article
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Open AccessReview ZnO Nanostructures for Tissue Engineering Applications
Nanomaterials 2017, 7(11), 374; https://doi.org/10.3390/nano7110374
Received: 13 October 2017 / Revised: 1 November 2017 / Accepted: 2 November 2017 / Published: 6 November 2017
Cited by 13 | PDF Full-text (11960 KB) | HTML Full-text | XML Full-text
Abstract
This review focuses on the most recent applications of zinc oxide (ZnO) nanostructures for tissue engineering. ZnO is one of the most investigated metal oxides, thanks to its multifunctional properties coupled with the ease of preparing various morphologies, such as nanowires, nanorods, and [...] Read more.
This review focuses on the most recent applications of zinc oxide (ZnO) nanostructures for tissue engineering. ZnO is one of the most investigated metal oxides, thanks to its multifunctional properties coupled with the ease of preparing various morphologies, such as nanowires, nanorods, and nanoparticles. Most ZnO applications are based on its semiconducting, catalytic and piezoelectric properties. However, several works have highlighted that ZnO nanostructures may successfully promote the growth, proliferation and differentiation of several cell lines, in combination with the rise of promising antibacterial activities. In particular, osteogenesis and angiogenesis have been effectively demonstrated in numerous cases. Such peculiarities have been observed both for pure nanostructured ZnO scaffolds as well as for three-dimensional ZnO-based hybrid composite scaffolds, fabricated by additive manufacturing technologies. Therefore, all these findings suggest that ZnO nanostructures represent a powerful tool in promoting the acceleration of diverse biological processes, finally leading to the formation of new living tissue useful for organ repair. Full article
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