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Looking into the Skin in Health and Disease: From Microscopy Imaging Techniques to Molecular Analysis (2nd Edition)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 29 June 2024 | Viewed by 2114

Special Issue Editors


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Guest Editor

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Guest Editor
Dermatology Department, Kalmar County Hospital, Kalmar, Sweden
Interests: skin cancer; skin inflammation; in vivo reflectance confocal microscopy; skin diagnostic techniques; skin physiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin constantly adapts in response to various physiological and pathological states. Moreover, skin is the most accessible organ of the human body and, in recent years, prodigious amounts of research have been done in the fields of imaging correlated with cellular and molecular biology techniques. This technological armamentarium has recently led to massive progress in the diagnosis, targeted treatment and investigation of pathophysiology of skin conditions. Nevertheless, new discoveries are in the research pipeline and many more are needed as there are still patients that develop skin diseases with no clear pathogenesis, nor an effective treatment.

With this Special Issue, we aim to expand our understanding and to emphasize new research directions related to investigation of various aspects of the physiology and pathology of the skin with emphasis on the cellular and molecular mechanisms. Therefore, we invite you to submit your interesting results related to the topic in the forms of original research, review articles or short communications.

Prof. Dr. Monica Neagu
Dr. Mihaela Adriana Ilie
Prof. Dr. Constantin Caruntu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin imaging
  • molecular analysis
  • skin physiology
  • dermatopathology
  • skin cancer
  • skin inflammation
  • molecular biology

Published Papers (2 papers)

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Research

18 pages, 9700 KiB  
Article
Secukinumab and Dead Sea Climatotherapy Impact Resolved Psoriasis Skin Differently Potentially Affecting Disease Memory
by Thomas Emmanuel, Borislav Ignatov, Trine Bertelsen, Thomas Litman, Morten Muhlig Nielsen, Mikkel Bo Brent, Toke Touborg, Anders Benjamin Rønsholdt, Annita Petersen, Mette Boye, Ida Kaaber, Daniel Sortebech, Dorte Lybæk, Torben Steiniche, Anne Bregnhøj, Liv Eidsmo, Lars Iversen and Claus Johansen
Int. J. Mol. Sci. 2024, 25(11), 6086; https://doi.org/10.3390/ijms25116086 - 31 May 2024
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Abstract
Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients, through distinct mechanisms. However, recurrence in the same areas after treatments suggests the existence of a molecular scar. We aimed to compare the molecular and genetic differences in psoriasis patients [...] Read more.
Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients, through distinct mechanisms. However, recurrence in the same areas after treatments suggests the existence of a molecular scar. We aimed to compare the molecular and genetic differences in psoriasis patients who achieved complete response from secukinumab and Dead Sea climatotherapy treatments. We performed quantitative immunohistochemical and transcriptomic analysis, in addition to digital spatial profiling of skin punch biopsies. Histologically, both treatments resulted in a normalization of the lesional skin to a level resembling nonlesional skin. Interestingly, the transcriptome was not normalized by either treatments. We revealed 479 differentially expressed genes between secukinumab and Dead Sea climatotherapy at the end of treatment, with a psoriasis panel identifying SERPINB4, SERPINB13, IL36G, IL36RN, and AKR1B10 as upregulated in Dead Sea climatotherapy compared with secukinumab. Using digital spatial profiling, pan-RAS was observed to be differentially expressed in the microenvironment surrounding CD103+ cells, and IDO1 was differentially expressed in the dermis when comparing the two treatments. The differences observed between secukinumab and Dead Sea climatotherapy suggest the presence of a molecular scar, which may stem from mechanistically different pathways and potentially contribute to disease recurrence. This may be important for determining treatment response duration and disease memory. Full article
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21 pages, 5899 KiB  
Article
Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study
by Arseniy Potapov, Lev Matveev, Alexander Moiseev, Elena Sedova, Maria Loginova, Maria Karabut, Irina Kuznetsova, Viktoriya Levchenko, Elena Grebenkina, Sergey Gamayunov, Stefka Radenska-Lopovok, Marina Sirotkina and Natalia Gladkova
Int. J. Mol. Sci. 2023, 24(18), 13967; https://doi.org/10.3390/ijms241813967 - 12 Sep 2023
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Abstract
Photodynamic therapy (PDT) is a modern treatment for severe or treatment-resistant vulvar lichen sclerosus (VLS). The chronic and recurrent nature of VLS requires control of recurrences at an early stage. In this paper, a non-invasive multimodal optical coherence tomography (OCT) method was used [...] Read more.
Photodynamic therapy (PDT) is a modern treatment for severe or treatment-resistant vulvar lichen sclerosus (VLS). The chronic and recurrent nature of VLS requires control of recurrences at an early stage. In this paper, a non-invasive multimodal optical coherence tomography (OCT) method was used to control for early histological signs of VLS recurrence after systemic PDT using Photodithazine®. To interpret the OCT data, a histological examination was performed before PDT and 3 months after PDT. Two groups of patients were identified: with early histological signs of VLS recurrence (Group I, n = 5) and without histological signs of VLS recurrence (Group II, n = 6). We use structural OCT, OCT angiography, and OCT lymphangiography throughout 6 months after PDT to visually assess the skin components and to quantitatively assess the dermis by calculating the depth-resolved attenuation coefficient and the density of blood and lymphatic vessels. The OCT data assessment showed a statistically significant difference between the patient groups 3 months after PDT. In Group II, all the studied OCT parameters reached maximum values by the 3rd month after PDT, which indicated recovery of the skin structure. At the same time, in Group I, the values of OCT parameters did not approach the values those in Group II even after 6 months. The obtained results of multimodal OCT can be used for non-invasive control of early histological recurrence of VLS after systemic PDT and for adjusting treatment tactics in advance, without waiting for new clinical manifestations of the disease. Full article
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