Applications of Functional Nanomaterials in Biomedical Science (2nd Edition)

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 779

Editors

Special Issue Information

Dear Colleagues,

In recent decades, many efforts have been focused on the discovery of various types of nanomaterials. In addition to basic research on the synthesis of nanoconstructs, the goal of such research has been to identify nanoparticles applicable in various fields, including technology (catalysis), medicine (drug delivery), etc. As a result of the increasing number of potential applications, the demand for novel nanomaterials is growing rapidly.

This Special Issue, titled “Applications of Functional Nanomaterials in Biomedical Science (2nd Edition)”, aims to showcase the most recent advances in nanomaterial synthesis and characterization, as well as their technological applications. This issue welcomes original research articles and reviews. Research areas may include all types of nanomaterials used in the development of medical applications, including, but not limited to, therapeutics (anticancer, antibacterial, toxicology, etc.), diagnostics (imaging, etc.), and nanodevices.

We look forward to hearing from you.

Prof. Dr. Goran Kaluđerović
Prof. Dr. Nebojša Pantelić
Guest Editors

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Keywords

  • nanoparticles
  • medicine
  • anticancer
  • antibacterial
  • antiviral
  • imaging
  • drug delivery

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Published Papers (1 paper)

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Research

24 pages, 1249 KB  
Article
Elucidating the Influence of Serum Concentration, Sex, and Particle Size on Iron Oxide Nanoparticle–Lipid Biocorona Formation
by Jenna N. Swihart, Christina R. Ferreira, Akshada Shinde and Jonathan H. Shannahan
Nanomaterials 2026, 16(11), 683; https://doi.org/10.3390/nano16110683 - 1 Jun 2026
Viewed by 497
Abstract
Biocorona (BC) formation is a critical determinant of nanoparticle (NP) biological identity and downstream interactions, yet lipid association within BCs remains comparatively understudied relative to proteins, despite its potential relevance to NP stability, biodistribution, cellular interactions, and clearance. A more complete understanding of [...] Read more.
Biocorona (BC) formation is a critical determinant of nanoparticle (NP) biological identity and downstream interactions, yet lipid association within BCs remains comparatively understudied relative to proteins, despite its potential relevance to NP stability, biodistribution, cellular interactions, and clearance. A more complete understanding of NP–lipid interactions is essential for optimizing NP-based therapies and supporting their safe clinical translation. In this study, we evaluated how serum concentration, biological sex, and NP size influence lipid association with iron oxide (Fe3O4) NP BCs. Lipids associated with 50 or 100 nm Fe3O4 NPs were characterized following incubation in male or female human serum across increasing serum concentrations of 5%, 10%, 25%, 50%, or 75% (v/v). Increasing serum concentration promoted greater lipid association and increased BC complexity, with higher serum conditions yielding more compositionally diverse lipid coronas. BCs formed on 50 nm Fe3O4 NPs consistently contained more lipid species than those formed on 100 nm Fe3O4 NPs, indicating pronounced size-dependent differences in lipid recruitment. BCs formed in male serum also contained more lipid species and a greater number of unique lipids than corresponding female BCs, demonstrating that biological sex significantly influenced both lipid composition and abundance within the BC. Rank-based comparisons further indicated that lipid association was governed not only by serum abundance but also by selective binding behaviors. Together, these findings demonstrate that lipid corona formation is strongly shaped by both the biofluid environment and NP design variables, emphasizing the importance of considering lipid coronas in NP design and evaluation, particularly for applications in drug delivery, nanomedicine, and precision diagnostics. Full article
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