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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Synthesis of Antiviral Compounds
edited by and Francesco Saccoliti
submission deadline 31 Jan 2026 | Viewed by 702 | Submission Open
Keywords: antiviral; drug design; medicinal chemistry; antiviral small molecules; synthesis; synthetic drugs; antimicrobial
(This special issue belongs to the Section Organic Chemistry)
Emerging Trends in Microextraction Techniques for Bioanalytical Applications submission deadline 31 Jan 2026 | 1 articles | Viewed by 573 | Submission Open
Keywords: sorbent-based microextraction (i.e.; solid phase microextraction (SPME); matrix solid phase dispersion (MSPD); pipette-tip micro solid phase extraction; fabric sorptive phase extraction (FPSE); capsule phase microextraction (CPME); stir bar sorptive extraction (SBSE); etc.); liquid-phase microextraction (dispersive liquid– liquid microextraction; single-drop microextraction; electromembrane extraction; etc.); automation; new materials/sorbents (MOF; COFs; nanomaterials; conductive polymers; magnetic materials; etc.); miniaturization in sample preparation
(This special issue belongs to the Section Analytical Chemistry)
From Biodiversity to the Modern Use of Medicinal Plants
edited by , Raimundo Gonçalves De Oliveira Junior, and
submission deadline 31 Jan 2026 | Viewed by 567 | Submission Open
Keywords: rational phytotherapy; phytochemical composition; pharmaco-toxicological evaluation; composition/activity relationship; unexplored plant extract; plant biodiversity
(This special issue belongs to the Section Natural Products Chemistry)
Vitrimers and Sustainable Polymers: Pioneering Recycling and Controlled Degradation
edited by and Marc Guerre
submission deadline 31 Jan 2026 | Viewed by 492 | Submission Open
Keywords: vitrimers; polymer recycling; debonding technologies; circular economy; controlled biodegradation; sustainable polymers; environmental impact
(This special issue belongs to the Section Macromolecular Chemistry)
Research on Food Packaging Materials: Development of Innovative Polymers and Analytical Characterization submission deadline 31 Jan 2026 | 1 articles | Viewed by 492 | Submission Open
Keywords: food packaging materials; chemical contamination; analytical characterization; food preservative properties; innovative polymers
(This special issue belongs to the Section Materials Chemistry)
Advances in High-Performance Liquid Chromatography and Novel Applications submission deadline 31 Jan 2026 | Viewed by 339 | Submission Open
Keywords: HPLC; mass spectrometry; fundamentals; stationary phase; artificial intelligence; sampling; sample preparation; hyphenation; hyphenated techniques; green chemistry
(This special issue belongs to the Section Analytical Chemistry)
Recent Progress in Advanced Microwave Absorption Materials: Synthesis, Structure and Application
edited by and Xiaolin Lan
submission deadline 31 Jan 2026 | Viewed by 329 | Submission Open
Keywords: advanced microwave absorption materials; new methods and design strategies; new preparation and characterization concepts; electromagnetic attenuation mechanism; intelligent/smart and multiple functions
(This special issue belongs to the Section Materials Chemistry)
Chemistry and Pediatric Cancer Therapy: Small Molecules and Protein Degraders in Drug Discovery
edited by Gisele Nishiguchi and
submission deadline 31 Jan 2026 | Viewed by 318 | Submission Open
Keywords: drug design; small molecules; protein; computational medicinal chemistry; anticancer; medicinal chemistry; biomolecular interactions
(This special issue belongs to the Section Medicinal Chemistry)
Research on Plant-Based Polyphenols: Extraction, Purification and Application submission deadline 31 Jan 2026 | Viewed by 317 | Submission Open
Keywords: condensed tannin; biopolymers; extraction; circular economy; deep eutectic solvent; hydrolysable tannin; residue valorization
(This special issue belongs to the Section Natural Products Chemistry)
Beyond Convention: Novel Sources, Strategies, and Technologies for Researching Fungal Bioactives submission deadline 31 Jan 2026 | Viewed by 281 | Submission Open
Keywords: fungal bioactives; genome mining; metagenomics; synthetic biology; AI-driven discovery; structure elucidation; extremophilic fungi; drug discovery pipelines
One Health Drugs Against Vector-Borne Parasitic Diseases—a Sustainable Chemical/Biological Approach submission deadline 31 Jan 2026 | Viewed by 250 | Submission Open
Keywords: vector-borne diseases; parasitic diseases; antiparasitic drugs; transmission-blocking drugs; chemotherapy; drug resistance; drug repurposing; pharmacokinetics; natural products; organic production; host-directed therapy; combination therapy; in vitro/in vivo models; drug delivery systems; nanomedicine; pharmacodynamics
(This special issue belongs to the Section Medicinal Chemistry)
Advances of Ionic Liquids in Organic, Polymer and Material Chemistry: Key Trends in Green Chemistry: 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 241 | Submission Open
Keywords: ionic liquids; green solvents; catalysts; polymer synthesis; advanced materials; electrochemical devices; separation process; nano-materials; biomolecules
(This special issue belongs to the Section Green Chemistry)
Innovative Green and Photochemical Approaches for Sustainable Organic Synthesis
edited by
submission deadline 31 Jan 2026 | Viewed by 231 | Submission Open
Keywords: green chemistry; photochemistry; dual catalysis; photooxidation protocols; sustainable chemistry; material science; sustainable synthesis; green solvents; flow photochemistry; organic synthesis
(This special issue belongs to the Section Organic Chemistry)
Green Chemistry and Molecular Tools in Agriculture submission deadline 31 Jan 2026 | Viewed by 221 | Submission Open
Keywords: sustainable agriculture; green chemistry; agri-food by-products; bioactive compounds; biostimulants; circular economy; molecular tools; eco-friendly agrochemicals; soil health; precision agriculture
(This special issue belongs to the Section Green Chemistry)
Natural Products in Antibacterial Research of Plant and Food Extracts submission deadline 31 Jan 2026 | Viewed by 218 | Submission Open
Keywords: natural compounds; new antibacterials; extraction methods; chemistry; mechanism of action; food preservatives; anti-infectious agents; food-borne bacterial pathogens
(This special issue belongs to the Section Natural Products Chemistry)
Advances in Porphyrinoid-Based Functional Materials submission deadline 31 Jan 2026 | Viewed by 213 | Submission Open
Keywords: porphyrinoids; synthetic approaches; functional materials; medicine; environment; energy; sensing; catalysis
(This special issue belongs to the Section Organic Chemistry)
Advances in Synthesis and Biological Activity of Novel Derivatives Based on Five-Membered Heterocyclic Scaffolds and Their Intermediates, 3rd Edition submission deadline 31 Jan 2026 | Viewed by 210 | Submission Open
Keywords: bioactive heterocycles; heterocyclic scaffolds; bioisosteric heterocyclic skeletons; azoles; pyrazole; oxazole; triazole; oxadiazole; drug design; in silico studies
(This special issue belongs to the Section Organic Chemistry)
Interactions of Plant-Derived Foods and Medicines with the Gut Microbiome submission deadline 31 Jan 2026 | Viewed by 209 | Submission Open
Keywords: anti-inflammatory effect; antimicrobial activity; fermented foods; gut metabolism; gut microbiota; herbal product; immunomodulatory effect; microbiome therapy; phytochemical; plant-based diet; postbiotics; prebiotic effect; probiotic microorganisms
Cutting-Edge Developments in Antimicrobial Drug Discovery and Design submission deadline 31 Jan 2026 | Viewed by 209 | Submission Open
Keywords: antimicrobial activity; multidrug resistance; antibiotic resistance; pathogenic strains; phytochemicals; organic synthesis; computational drugs design; molecular modeling
(This special issue belongs to the Section Medicinal Chemistry)
Novel Research and Applications of Aptasensors Based on Evolutional Selection of Aptamers
edited by , and Liling Hao
submission deadline 31 Jan 2026 | Viewed by 208 | Submission Open
Keywords: aptasensor; food contaminant analysis; environment pollutant analysis; medical analysis; point-of-care testing; nanomaterial functionalization; artificial intelligence-aided analysis; process monitoring
(This special issue belongs to the Section Analytical Chemistry)
Analytical Studies of Bioactive Natural Products in Food submission deadline 31 Jan 2026 | Viewed by 205 | Submission Open
Keywords: natural products; bioactive compound; food chemistry; spectroscopic analysis; analytical chemistry
(This special issue belongs to the Section Food Chemistry)
Advanced Nanomaterials for Energy Storage Devices, 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 183 | Submission Open
Keywords: electrochemical energy storage; carbon nanomaterials; layered transition metal dichalcogenides; porous 1D nanomaterials; 2D transition metal carbides/nitride (MXene) nanomaterials; energy conversion and storage; fuel cells; batteries; flow batteries; supercapacitors; hydrogen production; storage and distribution; utilization of carbon dioxide
(This special issue belongs to the Section Inorganic Chemistry)
Biologically Active Molecules from Microbes and Plants
edited by
submission deadline 31 Jan 2026 | Viewed by 176 | Submission Open
Keywords: isolation; structural characterization; biological profiling; biological activity; anti-inflammatory; anti-bacterial; anti-cancer; secondary metabolite; microbe; plant; natural product; drug discovery; bio-discovery
(This special issue belongs to the Section Natural Products Chemistry)
Biological Activity of Essential Oils, 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 170 | Submission Open
Keywords: essential oil extraction and chemical analysis; biological potential of essential oils; aromatherapy; chemotypes (with/without biological potential variation); biofertilizers; postharvest preservatives
(This special issue belongs to the Section Natural Products Chemistry)
Aroma and Volatile Compounds from Foods
edited by
submission deadline 31 Jan 2026 | Viewed by 166 | Submission Open
Keywords: aroma compounds; volatile organic compounds (VOCs); food flavor; gas chromatography– mass spectrometry (GC-MS); odor activity value (OAV); food quality; food processing; sensory analysis
(This special issue belongs to the Section Flavours and Fragrances)
Synthesis, Properties and Application of Five- and Six-Membered Heterocycles
edited by Lara Bianchi and
submission deadline 31 Jan 2026 | Viewed by 154 | Submission Open
Keywords: heterocycle synthesis; transition-metal catalysis; multicomponent reactions; structural characterization; computational chemistry; pharmacological activity; functional materials; benzofused heterocycles
(This special issue belongs to the Section Organic Chemistry)
Recent Advances of Hydrogel Materials for Biomedical Applications submission deadline 31 Jan 2026 | Viewed by 144 | Submission Open
Keywords: hydrogels; biomedical applications; hydrogel synthesis; tissue engineering; drug delivery systems
(This special issue belongs to the Section Medicinal Chemistry)
Design and Synthesis of Antimicrobial and Antiviral Agents: From Molecular Targets to Therapeutic Strategies
edited by
submission deadline 31 Jan 2026 | Viewed by 139 | Submission Open
Keywords: antimicrobial drug discovery; antiviral agents; structure-based design; resistance mechanisms; medicinal chemistry; target identification; lead optimization; synthetic methodology; mechanism of action; therapeutic strategies
(This special issue belongs to the Section Medicinal Chemistry)
Computational Approaches in Drug Discovery and Design, 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 138 | Submission Open
Keywords: combined and integrated approaches in CADD; QM/MM and quantum chemical computations for protein–ligand binding; scoring function; binding free energy; target identification; molecular docking; molecular dynamics simulation; machine learning or deep learning; data fitting; database; pattern recognition; druglikeness; drug design or drug discovery
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Exclusive Feature Papers in Electrochemistry—2nd Edition
edited by and
submission deadline 31 Jan 2026 | Viewed by 135 | Submission Open
Keywords: electrochemical science; energy conversion; electrocatalysis; electrooxidation and electroreduction; (bio)sensors; corrosion science; environmental applications; new materials; green electrochemistry
(This special issue belongs to the Section Electrochemistry)
Novel Electrode Materials for Rechargeable Batteries, 3rd Edition
edited by and
submission deadline 31 Jan 2026 | Viewed by 121 | Submission Open
Keywords: energy; batteries; electrode materials; synthesis; characterization; practical application
(This special issue belongs to the Section Electrochemistry)
Recent Advances in the Synthesis and Structural Elucidation of Bioactive Lipid Mediators
edited by Robert Nshimiyimana and
submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open
Keywords: total synthesis; stereochemistry; resolution of inflammation; lipid mediators; structural elucidation; biosynthesis; eicosanoids; docosanoids
(This special issue belongs to the Section Organic Chemistry)
Battery Chemistry: Recent Advances and Future Opportunities, the Third Edition
edited by and
submission deadline 31 Jan 2026 | Viewed by 112 | Submission Open
Keywords: electrochemistry; surface/interface chemistry; electrocatalytic reaction; oxygen reduction reaction; oxygen evolution reaction; quantum chemistry; materials chemistry; rechargeable batteries
(This special issue belongs to the Section Electrochemistry)
Transition Metal Complexes for Small Molecule Bond Activation submission deadline 31 Jan 2026 | Viewed by 109 | Submission Open
Keywords: transition metal complex; bond activation; small molecule; functionalization; oxidative addition; metal– ligand and metal– metal cooperation; second coordination sphere interactions
(This special issue belongs to the Section Organic Chemistry)
Advanced Electrode Materials for Aqueous Batteries
edited by
submission deadline 31 Jan 2026 | Viewed by 106 | Submission Open
Keywords: aqueous batteries; electrode materials; energy storage; electrochemical stability; ion intercalation; nanostructured materials
(This special issue belongs to the Section Materials Chemistry)
Recent Advances in Supramolecular and Surface Photochemistry submission deadline 31 Jan 2026 | Viewed by 103 | Submission Open
Keywords: supramolecular photochemistry; organic photochemistry; photochemical synthesis; medicinal uses of photochemistry; biomolecular photochemistry; photochemical reaction mechanisms; photochemistry in confined spaces
(This special issue belongs to the Section Photochemistry)
Modern Trends of Biocatalysis in Organic Chemistry and Enzyme Engineering—3rd Edition
edited by and
submission deadline 31 Jan 2026 | Viewed by 86 | Submission Open
Keywords: enzyme engineering; biocatalytic promiscuity; enzyme immobilization; directed evolution; biocatalysis; enzymatic reactions
(This special issue belongs to the Section Bioorganic Chemistry)
Advanced Oxidation and Nanotechnology Treatment Methods of Pollutants
edited by , Weijie Xue and
submission deadline 31 Jan 2026 | Viewed by 86 | Submission Open
Keywords: advanced oxidation technology; heavy metal pollution; emerging contaminants; pollutant remediation; nanotechnology; micro-nano plastics; toxicity; water treatment; perfluorinated compounds
(This special issue belongs to the Section Green Chemistry)
Advances in Proton Exchange Membrane Technology for Fuel Cells submission deadline 31 Jan 2026 | Viewed by 77 | Submission Open
Keywords: proton exchange membrane (PEM); fuel cells; advanced membrane materials; proton conductivity; hydrogen energy technology; membrane– electrode interface; nanostructured composite membranes
(This special issue belongs to the Section Electrochemistry)
Metal–Oxygen Interfaces in Catalysis and Surface Chemistry: Interactions, Reactivity, and Modeling
edited by and Houqian Li
submission deadline 31 Jan 2026 | Viewed by 76 | Submission Open
Keywords: metal– oxide interfaces; surface chemistry; heterogeneous catalysis; reaction mechanisms; computational modeling; oxide-supported catalysts; structure– reactivity relationships
(This special issue belongs to the Section Cross-Field Chemistry)
Unlocking the Potential of Agro-Forestry Residues: Biomolecules for Diverse Applications and Multifunctional Uses submission deadline 31 Jan 2026 | Viewed by 70 | Submission Open
Keywords: waste management; recycling; lignin; tannins; cellulose; additives; eco-friendly materials; nanotechnology; sustainability; circular economy
(This special issue belongs to the Section Green Chemistry)
Natural Bioactives for Health: Therapeutic Promise and Safety Considerations submission deadline 31 Jan 2026 | Viewed by 53 | Submission Open
Keywords: natural bioactive compounds; drug discovery and development; pharmacological activities; toxicological evaluation; analytical and screening methods; human health
Recent Advances in Functionalized Nanofiber Materials
edited by
submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open
Keywords: nanofiber; electrospinning; sustainability; functionalization; surface and Interface; practical application
(This special issue belongs to the Section Materials Chemistry)
Chemical Composition and Biological Evaluation of Essential Oils submission deadline 15 Feb 2026 | 1 articles | Viewed by 1050 | Submission Open
Keywords: essential oils; biological evaluation; chemical composition; therapies; natural products
(This special issue belongs to the Section Natural Products Chemistry)
Excited State Dynamics, Photokinetics and Photochemistry
edited by
submission deadline 15 Feb 2026 | 1 articles | Viewed by 512 | Submission Open
Keywords: photodegradation; excited-state properties; photocatalysis; photochromes; therapeutic photo-drugs; photokinetics; actinometry
Design, Fabrication, and Applications of Nano-Membrane Materials
edited by and
submission deadline 16 Feb 2026 | Viewed by 142 | Submission Open
Keywords: nanomembranes; membrane fabrication; separation; waste purification; nanomaterials; advanced materials
(This special issue belongs to the Section Applied Chemistry)
Quantum-Chemical Studies for Superspecies—in Celebration of Professor Jean-François Gal’s 80th Birthday
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 958 | Submission Open
Keywords: structure of superspecies; neutral; ionic; and/or radical forms; isomerism; electron delocalization; energetic parameters of electron transfer; thermochemistry of proton transfer; quantum-chemical studies
Exploring Microorganisms and Their Bioactive Secondary Metabolites: From Nature to Application submission deadline 27 Feb 2026 | 1 articles | Viewed by 1571 | Submission Open
Keywords: natural products; bioactive compounds; microbial secondary metabolites; biological activity; chemical composition; biosynthetic pathways; strategies for discovery; mechanisms of action; biotechnological potential; therapeutic applications
(This special issue belongs to the Section Natural Products Chemistry)
Chromatographic Characterization of Food Using Analytical Methods
edited by
submission deadline 27 Feb 2026 | Viewed by 101 | Submission Open
Keywords: food analysis; chromatography; gas chromatography; high-performance liquid chromatography (HPLC); sample preparation (SPE; SPME; derivatization); mass spectrometry; chemometrics; food authenticity and adulteration; green analytical chemistry; artificial intelligence
(This special issue belongs to the Section Food Chemistry)
Natural Products: Isolation, Analysis and Biological Activity, 2nd Edition
edited by Hazem Salaheldin Elshafie and
submission deadline 28 Feb 2026 | 4 articles | Viewed by 32995 | Submission Open
Keywords: essential oils; plant extracts; biological activities; antiproliferative activity; enzymatic inhibitor activity; phytotoxic activity; bioactive compounds in natural products; secondary metabolites; structure– activity relationships; antimicrobial activity; phytopathogens
(This special issue belongs to the Section Natural Products Chemistry)
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